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Protein
Submitted name:

Myosin heavy chain 6

Gene

MYH6

Organism
Aotus nancymaae (Ma's night monkey)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi177 – 184ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotationSAAS annotation, Motor protein, MyosinPROSITE-ProRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Myosin heavy chain 6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYH6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAotus nancymaae (Ma's night monkey)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri37293 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniAotidaeAotus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233020 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Whole Genome Shotgun Assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 81Myosin N-terminal SH3-likeInterPro annotationAdd BLAST50
Domaini85 – 787Myosin motorInterPro annotationAdd BLAST703

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni664 – 686Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili858 – 1165Sequence analysisAdd BLAST308
Coiled coili1173 – 1193Sequence analysisAdd BLAST21
Coiled coili1202 – 1243Sequence analysisAdd BLAST42
Coiled coili1247 – 1383Sequence analysisAdd BLAST137
Coiled coili1385 – 1447Sequence analysisAdd BLAST63
Coiled coili1462 – 1605Sequence analysisAdd BLAST144
Coiled coili1617 – 1721Sequence analysisAdd BLAST105
Coiled coili1729 – 1812Sequence analysisAdd BLAST84
Coiled coili1814 – 1841Sequence analysisAdd BLAST28
Coiled coili1870 – 1932Sequence analysisAdd BLAST63

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysisSAAS annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154805

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00242 MYSc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

A0A2K5EW03-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDAQMADFG AAAQYLRKSE KERLEAQTRP FDIRTECFVP DDKEEFVKAK
60 70 80 90 100
IVSREGGKVT AETENGKTVT VKEDQVLQQN PPKFDKIEDM AMLTFLHEPA
110 120 130 140 150
VLFNLKERYA AWMIYTYSGL FCVTVNPYKW LPVYNAEVVA AYRGKKRSEA
160 170 180 190 200
PPHIFSISDN AYQYMLTGEP GDSWPLGESG AGKTVNTKRV IQYFASIAAI
210 220 230 240 250
GDRGKKDNAN ANKGTLEDQI IQANPALEAF GNAKTVRNDN SSRFGKFIRI
260 270 280 290 300
HFGATGKLAS ADIETCYRPP GPLYLLEKSR VIFQLKAERN YHIFYQILSN
310 320 330 340 350
KKPELLDMLL VTNNPYDYAF VSQGEVSVAS IDDSEELMAT DSAFDVLGFT
360 370 380 390 400
SEEKAGVYKL TGAIMHYGNM KFKQKQREEQ AEPDGTEDAD KSAYLMGLNS
410 420 430 440 450
ADLLKGLCHP RVKVGNEYVT KGQSVQQVYY SIGALAKAVY EKMFNWMVTR
460 470 480 490 500
INATLETKQP RQYFIGVLDI AGFEIFDFNS FEQLCINFTN EKLQQFFNHH
510 520 530 540 550
MFVLEQEEYK KEGIEWEFID FGMDLQACID LIEKPMGIMS ILEEECMFPK
560 570 580 590 600
ATDMTFKAKL YDNHLGKSNN FQKPRNIKGK PEAHFSLIHY AGTVDYNILG
610 620 630 640 650
WLEKNKDPLN ETVVALYQKS SLKLMATLFS TYASADSGDS GKSKGGKKKG
660 670 680 690 700
SSFQTVSALH RENLNKLMTN LRTTHPHFVR CIIPNERKAP GVMDNPLVMH
710 720 730 740 750
QLRCNGVLEG IRICRKGFPN RILYGDFRQR YRILNPAAIP EGQFIDSRKG
760 770 780 790 800
SEKLLSSLDI DHNQYKFGHT KVFFKAGLLG LLEEMRDERL SRILTRMQAQ
810 820 830 840 850
ARGQLMRIEF KKIVERRDAL LVIQWNIRAF MGVKNWPWMK LYFKIKPLLK
860 870 880 890 900
SAETEKEMAT MKEEFGRIKE TLEKSEARRK ELEEKMVSLL QEKNDLQLQV
910 920 930 940 950
QAEQDNLNDA EERCDQLIKN KIQLEAKVKE MNERLEDEEE MNAELTAKKR
960 970 980 990 1000
KLEDECSELK KDIDDLELTL AKVEKEKHAT ENKVKNLTEE MAGLDEIIAK
1010 1020 1030 1040 1050
LTKEKKALQE AHQQALDDLQ AEEDKVNSLS KSKVKLEQQV DDLEGSLEQE
1060 1070 1080 1090 1100
KKVRMDLERA KRKLEGDLKL TQESIMDLEN DKLQLDEKLK KKEFDINQLN
1110 1120 1130 1140 1150
SKIEDEQALA LQLQKKLKEN QARIEELEEE LEAERTARAK VEKLRSDLSR
1160 1170 1180 1190 1200
ELEEISERLE EAGGATSVQI EMNKKREAEF QKMRRDLEEA TLQHEATAAA
1210 1220 1230 1240 1250
LRKKHADSVA ELGEQIDNLQ RVKQKLEKEK SEFKLELDDV TSNMEHIIKA
1260 1270 1280 1290 1300
KANLEKVSRT LEDQANEYRV KLEEAQRSLN DFTTQRAKLQ TENGELARQL
1310 1320 1330 1340 1350
EEKEALISQL TRGKLSYTQQ MEDLKRQLEE EGKAKNALAH ALQSARHDCD
1360 1370 1380 1390 1400
LLREQYEEET EAKAELQRVL SKANSEVAQW RTKYETDAIQ RTEELEEAKK
1410 1420 1430 1440 1450
KLAQRLQDAE EAVEAVNAKC SSLEKTKHRL QNEIEDLMVD VERSNAAAAA
1460 1470 1480 1490 1500
LDKKQRNFDK ILAEWKQKYE ESQSELESSQ KEARSLSTEL FKLKNAYEES
1510 1520 1530 1540 1550
LEHLETFKRE NKNLQEEISD LTEQLGEGGK NVHELEKVRK QLEVEKLELQ
1560 1570 1580 1590 1600
SALEEAEASL EHEEGKILRA QLEFNQIKAE IERKLAEKDE EMEQAKRNHQ
1610 1620 1630 1640 1650
RVVDSLQTSL DAETRSRNEA LRVKKKMEGD LNEMEIQLSH ANRMAAEAQK
1660 1670 1680 1690 1700
QVKSLQSLLK DTQIQLDDAV RANDDLKENI AIVERRNNLL QAELEELRAV
1710 1720 1730 1740 1750
VEQTERSRKL AEQELIETSE RVQLLHSQNT SLINQKKKME SDLTQLQSEV
1760 1770 1780 1790 1800
EEAVQECRNA EEKAKKAITD AAMMAEELKK EQDTSAHLER MKKNMEQTIK
1810 1820 1830 1840 1850
DLQHRLDEAE QIALKGGKKQ LQKLEARVRE LEGELEAEQK RNAESVKGMR
1860 1870 1880 1890 1900
KSERRIKELT YQTEEDKKNL LRLQDLVDKL QLKVKAYKRQ AEEAEEQANT
1910 1920 1930 1940
NLSKFRKVQH ELDEAEERAD IAESQVNKLR AKSRDIGAKQ KMHDEE
Length:1,946
Mass (Da):224,198
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA672170E7A827181
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K5EW50A0A2K5EW50_AOTNA
Myosin heavy chain 6
MYH6
1,917Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5EW19A0A2K5EW19_AOTNA
Myosin heavy chain 6
MYH6
1,927Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5EW61A0A2K5EW61_AOTNA
Myosin heavy chain 6
MYH6
1,935Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5EVG0A0A2K5EVG0_AOTNA
Myosin heavy chain 6
MYH6
1,937Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5EV65A0A2K5EV65_AOTNA
Myosin heavy chain 6
MYH6
1,937Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5EW08A0A2K5EW08_AOTNA
Myosin heavy chain 6
MYH6
1,939Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSANAT00000055496; ENSANAP00000037414; ENSANAG00000036061

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSANAT00000055496; ENSANAP00000037414; ENSANAG00000036061

Phylogenomic databases

GeneTreeiENSGT00940000154805

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K5EW03_AOTNA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K5EW03
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: December 5, 2018
This is version 8 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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