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Protein
Submitted name:

Cut like homeobox 1

Gene

CUX1

Organism
Aotus nancymaae (Ma's night monkey)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cut like homeobox 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CUX1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAotus nancymaae (Ma's night monkey)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri37293 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniAotidaeAotus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233020 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Whole Genome Shotgun Assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini489 – 576CUTInterPro annotationAdd BLAST88
Domaini830 – 917CUTInterPro annotationAdd BLAST88
Domaini1013 – 1100CUTInterPro annotationAdd BLAST88

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili55 – 139Sequence analysisAdd BLAST85
Coiled coili144 – 171Sequence analysisAdd BLAST28
Coiled coili232 – 266Sequence analysisAdd BLAST35
Coiled coili271 – 291Sequence analysisAdd BLAST21
Coiled coili625 – 645Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159751

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003350 CUT_dom
IPR010982 Lambda_DNA-bd_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02376 CUT, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01109 CUT, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47413 SSF47413, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51042 CUT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

A0A2K5CJV2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTFPYLDHLA KTLAPNKIDA LSKRSKEAEA AFLNVYKRLI DVPDPVPALD
60 70 80 90 100
LGQQLQLKVQ RLHDIETENQ KLRETLEEYN KEFAEVMNQE VTIKALKEKI
110 120 130 140 150
REYEQTLKNQ AETIALEKEQ KLQNDFAEKE RKLQETQMST TSKLEEAEHK
160 170 180 190 200
VQSLQTALEK TRTELFDLKT KYDEETTAKA DEIEMIMTDL ERANQGKSKQ
210 220 230 240 250
RQEAASSSAL WPVQFCHLIS PPQEQAIEVL TRSSLEVELA AKEREIAQLV
260 270 280 290 300
EDVQRLQAGL TKLRENSASQ ISQLEQQLSS KNSTLKQLEE KLKGQADYEE
310 320 330 340 350
VKKELNILKS MEFAPSEGAG TQDAAKPLEV LLLEKNRSLQ SENAALRISN
360 370 380 390 400
SDLSGSARRK GKDQPESRRP GSLPAPPPSQ LPRNPGEQAS NTNGTHQFSP
410 420 430 440 450
AGLSQDFFSS SLASPSLPLA STGKFALNSL LQRQLMQSFY SKAMQEAGST
460 470 480 490 500
SMIFSTGPYS TNSISSQSPL QQSPDVNGMA PSPSQSESAG SVSEGEDMDT
510 520 530 540 550
AEIARQVKEQ LIKHNIGQRI FGHYVLGLSQ GSVSEILARP KPWNKLTVRG
560 570 580 590 600
KEPFHKMKQF LSDEQNILAL RSIQGRQRGN ITTRIRASET GSDEAIKSIL
610 620 630 640 650
EQAKRELQVQ KTGTRNSDDA IRSILQQARA EMEAQQAALD PALKQAPLSQ
660 670 680 690 700
SDITILTPKL LSTSPMPTVS TYPPLAISLK KPPAAPEAGA SALPNPGPQG
710 720 730 740 750
RPRTPGLDPQ GVADCAQGVL RQVKNEVGRS GAWKDHWWSA VQVQPERRNA
760 770 780 790 800
TASSEEAKAE EAGSGKEKGS GGGSQPRAER SQLQGPASSE YWKEWPSAES
810 820 830 840 850
PYSQSSELSL TGPASETPQN TLGPPLTPEQ YEVYMYQEVD TIELTRQVKE
860 870 880 890 900
KLAKNGICQR IFGEKVLGLS QGSVSDMLSR PKPWSKLTQK GREPFIRMQL
910 920 930 940 950
WLNGELGQGV LPVQGQQQGP VLHSVTSLQD PLQQGCVSSE STPKTSASCS
960 970 980 990 1000
PAPESPMSSS ESVKSLTELV QQPCPPIEAN KDGKPPEPSD PPASDSQPAT
1010 1020 1030 1040 1050
PLPLSGHSAL SIQELVAMSP ELDTYGITKR VKEVLTDNNL GQRLFGETIL
1060 1070 1080 1090 1100
GLTQGSVSDL LARPKPWHKL SLKGREPFVR MQLWLNDPNN VEKLMDMKRM
1110 1120 1130 1140 1150
EKKAYMKRRH SSVSDTQPCE PPSVGTEYSQ GASPQPQHQL KKPRVVLAPE
1160 1170 1180 1190 1200
EKELNLETST VINWFHNYRS RIRRELFIEE IQAGSQGQAG ASDSPSARSG
1210 1220 1230 1240 1250
RAAPSSEGDS CDGVEPPRAR AQTEPPPSGT PGPDDAGGPA DGPGPLPSPA
1260 1270 1280 1290 1300
TATATATAAP DAATSAAAPP GEGPAAPSSA PPPGAAGSSA PRRPSSLQSL
1310 1320 1330 1340
FGLPEAAGAR DSRDNPLRKK KAANLNSIIH RLEKAASREE PIEWEF
Length:1,346
Mass (Da):146,612
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8C3BF5A603391EE2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K5CJW1A0A2K5CJW1_AOTNA
Cut like homeobox 1
CUX1
1,406Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5CJU8A0A2K5CJU8_AOTNA
Cut like homeobox 1
CUX1
589Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5CJK7A0A2K5CJK7_AOTNA
Cut like homeobox 1
CUX1
618Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5CJU0A0A2K5CJU0_AOTNA
Cut like homeobox 1
CUX1
635Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5CJT7A0A2K5CJT7_AOTNA
Cut like homeobox 1
CUX1
596Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5CK15A0A2K5CK15_AOTNA
Cut like homeobox 1
CUX1
1,375Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5CK19A0A2K5CK19_AOTNA
Cut like homeobox 1
CUX1
1,318Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSANAT00000026781; ENSANAP00000008995; ENSANAG00000022374

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSANAT00000026781; ENSANAP00000008995; ENSANAG00000022374

Phylogenomic databases

GeneTreeiENSGT00940000159751

Family and domain databases

InterProiView protein in InterPro
IPR003350 CUT_dom
IPR010982 Lambda_DNA-bd_dom_sf
PfamiView protein in Pfam
PF02376 CUT, 3 hits
SMARTiView protein in SMART
SM01109 CUT, 3 hits
SUPFAMiSSF47413 SSF47413, 3 hits
PROSITEiView protein in PROSITE
PS51042 CUT, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K5CJV2_AOTNA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K5CJV2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: December 5, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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