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Protein

Inhibitor of growth protein

Gene

ING4

Organism
Aotus nancymaae (Ma's night monkey)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibitor of growth proteinUniRule annotation
Gene namesi
Name:ING4Imported
OrganismiAotus nancymaae (Ma's night monkey)Imported
Taxonomic identifieri37293 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniAotidaeAotus
Proteomesi
  • UP000233020 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Subunit structurei

Interacts with H3K4me3 and to a lesser extent with H3K4me2.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

SMRiA0A2K5C1X3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini195 – 244PHD-typeInterPro annotationAdd BLAST50

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili28 – 48Sequence analysisAdd BLAST21
Coiled coili97 – 117Sequence analysisAdd BLAST21

Domaini

The PHD-type zinc finger mediates the binding to H3K4me3.UniRule annotation

Sequence similaritiesi

Belongs to the ING family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00550000074538

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR028647 ING4
IPR024610 ING_N_histone_binding
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10333:SF40 PTHR10333:SF40, 1 hit
PfamiView protein in Pfam
PF12998 ING, 1 hit
SMARTiView protein in SMART
SM01408 ING, 1 hit
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

A0A2K5C1X3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAGMYLEHY LDSIENLPFE LQRNFQLMRD LDQRTEDLKA EIDKLATEYM
60 70 80 90 100
SSARSLSSEE KLALLKQIQE AYGKCKEFGD DKVQLAMQTY EMVDKHIRRL
110 120 130 140 150
DTDLARFEAD LKEKQIESSD YDSSSSKGKK SRTQKEKKAA RARSKGKNSD
160 170 180 190 200
EEAPKTAQKK LKLVRTSPEY GMPSVTFGSV HPSDVLDMPV DPNEPTYCLC
210 220 230 240
HQVSYGEMIG CDNPDCSIEW FHFACVGLTT KPRGKWFCPR CSQERKKK
Length:248
Mass (Da):28,432
Last modified:March 28, 2018 - v1
Checksum:i76907CB2119B07E8
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K5C240A0A2K5C240_AOTNA
Inhibitor of growth protein
ING4
225Annotation score:
A0A2K5C223A0A2K5C223_AOTNA
Inhibitor of growth family member 4
ING4
179Annotation score:
A0A2K5C228A0A2K5C228_AOTNA
Inhibitor of growth family member 4
ING4
51Annotation score:

Sequence databases

RefSeqiXP_012328235.1, XM_012472812.1

Genome annotation databases

EnsembliENSANAT00000020149; ENSANAP00000002708; ENSANAG00000018382
GeneIDi105731170

Similar proteinsi

Entry informationi

Entry nameiA0A2K5C1X3_AOTNA
AccessioniPrimary (citable) accession number: A0A2K5C1X3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: September 12, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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