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Entry version 17 (02 Jun 2021)
Sequence version 1 (28 Mar 2018)
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Protein

DUF4378 domain-containing protein

Gene

PHYPA_011379

Organism
Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DUF4378 domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PHYPA_011379Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPhyscomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3218 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaBryophytaBryophytinaBryopsidaFunariidaeFunarialesFunariaceaePhyscomitrium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006727 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1260 – 1427DUF4378InterPro annotationAdd BLAST168

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni19 – 40DisorderedSequence analysisAdd BLAST22
Regioni90 – 185DisorderedSequence analysisAdd BLAST96
Regioni306 – 371DisorderedSequence analysisAdd BLAST66
Regioni460 – 495DisorderedSequence analysisAdd BLAST36
Regioni544 – 564DisorderedSequence analysisAdd BLAST21
Regioni638 – 662DisorderedSequence analysisAdd BLAST25
Regioni774 – 932DisorderedSequence analysisAdd BLAST159
Regioni1086 – 1122DisorderedSequence analysisAdd BLAST37

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili604 – 624Sequence analysisAdd BLAST21
Coiled coili1290 – 1310Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi128 – 145Polar residuesSequence analysisAdd BLAST18
Compositional biasi161 – 175Polar residuesSequence analysisAdd BLAST15
Compositional biasi318 – 345Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi357 – 371Polar residuesSequence analysisAdd BLAST15
Compositional biasi460 – 480Polar residuesSequence analysisAdd BLAST21
Compositional biasi546 – 560Polar residuesSequence analysisAdd BLAST15
Compositional biasi640 – 662Polar residuesSequence analysisAdd BLAST23
Compositional biasi774 – 795Polar residuesSequence analysisAdd BLAST22
Compositional biasi814 – 828Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi842 – 878Polar residuesSequence analysisAdd BLAST37
Compositional biasi880 – 926Basic and acidic residuesSequence analysisAdd BLAST47
Compositional biasi1088 – 1109Polar residuesSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
185064at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025486, DUF4378
IPR033334, LNG1/2

The PANTHER Classification System

More...
PANTHERi
PTHR31680, PTHR31680, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14309, DUF4378, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2K1K6S5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGLFQIFDR YRALARSKNV PKKAGPVSHG QAQPGGERDP SCINLAYHMF
60 70 80 90 100
QDETGQRRVT LAGNHHLPQL EASRDPRRSS IDNSEVIVAK TLDTPKDIQL
110 120 130 140 150
ASEPKPHPPR TSLDSRPKPR LSLYLKDEAS VNDTSAPSSA KDISVSIETP
160 170 180 190 200
GDPLSRVHYP RSHSTAATPR SSVDGKVTGN DDRERKFRDL KGMLKGPFKR
210 220 230 240 250
KVTKVNNQES PGTSFDSKES DQVKTVRELQ PENKEDLNGL PKSGQIAPGG
260 270 280 290 300
NEYKDCGIFP GIHTGWFEGR EASTPRLTVE LKDGPKLTRK DDQRVLNDDR
310 320 330 340 350
LRVSEQKGSS VSLRFEEAPD VEGSKDLRKM GLGRNSIDGR ESSRPPFDGK
360 370 380 390 400
TVGSRLSVDG SRGSHQPSGM PRLSLISVVG REAHGQVTAN NWFAQNIHTS
410 420 430 440 450
LEASTPVFRR EENAWCDSPG RWIASTWDGD FDDSKWKASS VVARLMGLED
460 470 480 490 500
LPNFDVVSNA ESATEMSPEE QCSSPQTGPY YMEPDESPSR DDEDSYQVFG
510 520 530 540 550
TDEVVTPLRK DTPSKFMPGV PLVLPARQLA ISVSTAPRLQ LGYCKSPDSR
560 570 580 590 600
GQQTPASPKY SAVSPKHHMI ESLPQVLKHQ VELKISSEGL LYSDMDQRLR
610 620 630 640 650
QLGLKNTIQE RKTLKQILEA MHQKGLLQPP PHVNPEWKRN LPRHSSNSGA
660 670 680 690 700
AKSSFLNRKD RSSSQALDSF NDDLFGLDYK DIPMYVSAKM AKGPAEGGHV
710 720 730 740 750
SDSCKSPLRG RTGEASIVVM KPLNSNSASK LILAKPSLEV DLEKEQETVI
760 770 780 790 800
ARVTNAPTSL STLATPVATL TKDGSSVMNI RHSSKNETSA ASRKLKLSSK
810 820 830 840 850
SDDSRSQSAM EEVSISVKHR RERIAAQTAK FKSESGDLQQ HDSPKSTRSL
860 870 880 890 900
SPSGRKSAKT GSSIRSAFGS SLSQSGKAKS RARPVEKKDV KSTTQTTRRA
910 920 930 940 950
KHSQEQLKEG STTKQEHRRA PRRITSDRKW VAGNNTENIP ALEQFRNSKS
960 970 980 990 1000
AGEVAVLRSK RTETGGSNDQ FSSATPADVD TKGRRVMNFD KYQLAQLCSE
1010 1020 1030 1040 1050
FVESTADSCS ESQDITLERS LNGSPINVTS PTLTVFESRR LSSRRHSLEK
1060 1070 1080 1090 1100
LPDDFYDAKE RYESKLEDSE LETYSDVALY TDLDSSDVPM SREAQIQEPE
1110 1120 1130 1140 1150
SSALDSLEPS SPGFQEWREG REGGNGQMAK YIEQPSPISV LKNINFQKEE
1160 1170 1180 1190 1200
FTPSPKFEKS GFISARDCCA FESGEEQEDL KKPIWQPTDL STPAHQIPVF
1210 1220 1230 1240 1250
SGDPLKDLMH KVARSLNLDD QNSFLNKPTL EIQVPYVSDL FSPSSLNSVP
1260 1270 1280 1290 1300
PSFFSKEDEK AYVKHIMVAS GVTEECTAPK EWSKYGSLMK ADLFDQLEEH
1310 1320 1330 1340 1350
LELRESARKQ NAYLSGEERT EYLKQALDRR LLFDCVNSIL ERKWHSYFHP
1360 1370 1380 1390 1400
HPWGAQTFRK KPIGVKLVEE IWEELESLRS CALDDDSLYG ILQMDFTQRA
1410 1420 1430 1440
EKWVDFSLEV GEISTEIQEM ILDELVNAAV QEWSDESKFH
Length:1,440
Mass (Da):160,383
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B0D639C6CD1BA0A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ABEU02000008 Genomic DNA Translation: PNR49483.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
Pp3c8_11260V3.1; Pp3c8_11260V3.1; Pp3c8_11260
Pp3c8_11260V3.2; Pp3c8_11260V3.2; Pp3c8_11260

Gramene; a comparative resource for plants

More...
Gramenei
Pp3c8_11260V3.1; Pp3c8_11260V3.1; Pp3c8_11260
Pp3c8_11260V3.2; Pp3c8_11260V3.2; Pp3c8_11260

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABEU02000008 Genomic DNA Translation: PNR49483.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblPlantsiPp3c8_11260V3.1; Pp3c8_11260V3.1; Pp3c8_11260
Pp3c8_11260V3.2; Pp3c8_11260V3.2; Pp3c8_11260
GrameneiPp3c8_11260V3.1; Pp3c8_11260V3.1; Pp3c8_11260
Pp3c8_11260V3.2; Pp3c8_11260V3.2; Pp3c8_11260

Phylogenomic databases

OrthoDBi185064at2759

Family and domain databases

InterProiView protein in InterPro
IPR025486, DUF4378
IPR033334, LNG1/2
PANTHERiPTHR31680, PTHR31680, 1 hit
PfamiView protein in Pfam
PF14309, DUF4378, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K1K6S5_PHYPA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K1K6S5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: June 2, 2021
This is version 17 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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