BIRC2

Functionⁱ

GO - Molecular functionⁱ

chaperone binding Source: Ensembl
FBXO family protein binding Source: Ensembl
identical protein binding Source: Ensembl
protein N-terminus binding Source: Ensembl
transcription coactivator activity Source: Ensembl
ubiquitin binding Source: Ensembl
ubiquitin-protein transferase activity Source: Ensembl
zinc ion binding Source: Ensembl

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to tumor necrosis factor Source: Ensembl
necroptotic process Source: Ensembl
negative regulation of apoptotic process Source: Ensembl
negative regulation of necroptotic process Source: Ensembl
negative regulation of ripoptosome assembly involved in necroptotic process Source: Ensembl
placenta development Source: Ensembl
positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
positive regulation of protein K48-linked ubiquitination Source: Ensembl
positive regulation of protein K63-linked ubiquitination Source: Ensembl
positive regulation of protein monoubiquitination Source: Ensembl
proteasome-mediated ubiquitin-dependent protein catabolic process Source: Ensembl
protein polyubiquitination Source: Ensembl
regulation of cell cycle Source: Ensembl
regulation of NIK/NF-kappaB signaling Source: Ensembl
regulation of reactive oxygen species metabolic process Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Uncharacterized proteinImported
Gene namesⁱ	Name:BIRC2Imported
Organismⁱ	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
Taxonomic identifierⁱ	9601 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Ponginae › Pongo
Proteomesⁱ	UP000001595 Componentⁱ: Chromosome 11

Keywords - Cellular componentⁱ

NucleusARBA annotation

Interactionⁱ

GO - Molecular functionⁱ

chaperone binding Source: Ensembl
FBXO family protein binding Source: Ensembl
identical protein binding Source: Ensembl
protein N-terminus binding Source: Ensembl
ubiquitin binding Source: Ensembl

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9601.ENSPPYP00000004356

STRINGⁱ

9601.ENSPPYP00000004356

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the IAP family.ARBA annotation

Keywords - Domainⁱ

RepeatARBA annotation, Zinc-fingerARBA annotation

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000154175
HOGENOMⁱ	CLU_016347_1_1_1
OMAⁱ	FQRLTCV
Database of Orthologous Groups More...OrthoDBⁱ	1340284at2759
TreeFamⁱ	TF105356

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00022, BIR, 3 hits cd14394, UBA_BIRC2_3, 1 hit
InterProⁱ	View protein in InterPro IPR001370, BIR_rpt IPR041933, BIRC2/BIRC3_UBA IPR001315, CARD IPR011029, DEATH-like_dom_sf IPR001841, Znf_RING
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00653, BIR, 3 hits PF00619, CARD, 1 hit
SMARTⁱ	View protein in SMART SM00238, BIR, 3 hits SM00114, CARD, 1 hit SM00184, RING, 1 hit
SUPFAMⁱ	SSF47986, SSF47986, 1 hit
PROSITEⁱ	View protein in PROSITE PS01282, BIR_REPEAT_1, 3 hits PS50143, BIR_REPEAT_2, 3 hits PS50209, CARD, 1 hit PS50089, ZF_RING_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A2J8XX36-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEDSTILSDW TNSNKQKMKY DFSCELYRMS TYSTFPAGVP VSERSLARAG 
        60         70         80         90        100
FYYTGVNDKV KCFCCGLMLD NWKLGDSPIQ KHKQLYPSCS FIQNLVSASL 
       110        120        130        140        150
GSTSKNTSPM RNSFAHSLSP TLEHSSLFSG SYSSLSPNPL NSRAVEDFSS 
       160        170        180        190        200
SRTNPYSYAM STEEARFLTY HMWPLTFLSP SELARAGFYY IGPGDRVACF 
       210        220        230        240        250
ACGGKLSNWE PKDDAMSEHR RHFPNCPFLE NSLETLRFSI SNLSMQTHAA 
       260        270        280        290        300
RMRTFMYWPS SVPVQPEQLA SAGFYYVGRN DDVKCFCCDG GLRCWESGDD 
       310        320        330        340        350
PWVEHAKWFP RCEFLIRMKG QEFVDEIQGR YPHLLEQLLS TSDTTGEENA 
       360        370        380        390        400
DPPIIHFGPG ESSSEDAVMM NTPVVKSALE MGFNRDLVKQ TVQSKILTTG 
       410        420        430        440        450
ENYKTVNDIV SALLNAEDEK REEEKEKQAE EMASDDLSLI RKNRMALFQQ 
       460        470        480        490        500
LTCVLPILDN LLKANVINKQ EHDIIKQKTQ IPLQARELID TILVKGNAAA 
       510        520        530        540        550
NIFKNCLKEI DSTLYKNLFV DKNMKYIPTE DVSGLSLEEQ LRRLQEERTC 
       560        570        580        590 
KVCMDKEVSI VFIPCGHLVV CQECAPSLRK CPICRGIIKG TVRTFLS

Length:597

Mass (Da):67,562

Last modified:April 25, 2018 - v1

Checksum:ⁱ318E81FD3C51786E

GO

Sequence databases

NCBI Reference Sequences More...RefSeqⁱ	XP_009245268.1, XM_009246993.1

RefSeqⁱ

XP_009245268.1, XM_009246993.1

Genome annotation databases

Ensemblⁱ	ENSPPYT00000004531; ENSPPYP00000004356; ENSPPYG00000003808
GeneIDⁱ	100457858
KEGGⁱ	pon:100457858

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A0A2J8XX36	BIRC2 isoform 10		PONAB		597	UniRef100_A0A6D2XY77
BIRC2 isoform 3		PONAB		569
BIRC2 isoform 9 (Fragment)		PONAB		149

Protein	Similar proteins		Species	Score	Length	Source
A0A2J8XX36	Baculoviral IAP repeat-containing protein 2	)	HUMAN		618	UniRef90_Q13490
Uncharacterized protein		PANPA		618
BIRC2 isoform 5 (Fragment)		PONAB		183
LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 2		LIPVE		621
baculoviral IAP repeat-containing protein 2		BALAS		620
+142

Protein	Similar proteins		Species	Score	Length	Source
A0A2J8XX36	Baculoviral IAP repeat-containing protein 2	)	HUMAN		618	UniRef50_Q13490
Uncharacterized protein		PANPA		618
BIRC2 isoform 5 (Fragment)		PONAB		183
LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 2		LIPVE		621
baculoviral IAP repeat-containing protein 2		TURTR		620
+464

Cross-referencesⁱ

Sequence databases

RefSeqⁱ	XP_009245268.1, XM_009246993.1

RefSeqⁱ

XP_009245268.1, XM_009246993.1

3D structure databases

ModBaseⁱ	Search...
SWISS-MODEL-Workspaceⁱ	Submit a new modelling project...

Protein-protein interaction databases

STRINGⁱ	9601.ENSPPYP00000004356

STRINGⁱ

9601.ENSPPYP00000004356

Genome annotation databases

Ensemblⁱ	ENSPPYT00000004531; ENSPPYP00000004356; ENSPPYG00000003808
GeneIDⁱ	100457858
KEGGⁱ	pon:100457858

Organism-specific databases

CTDⁱ	329

CTDⁱ

329

Phylogenomic databases

GeneTreeⁱ	ENSGT00940000154175
HOGENOMⁱ	CLU_016347_1_1_1
OMAⁱ	FQRLTCV
OrthoDBⁱ	1340284at2759
TreeFamⁱ	TF105356

Family and domain databases

CDDⁱ	cd00022, BIR, 3 hits cd14394, UBA_BIRC2_3, 1 hit
InterProⁱ	View protein in InterPro IPR001370, BIR_rpt IPR041933, BIRC2/BIRC3_UBA IPR001315, CARD IPR011029, DEATH-like_dom_sf IPR001841, Znf_RING
Pfamⁱ	View protein in Pfam PF00653, BIR, 3 hits PF00619, CARD, 1 hit
SMARTⁱ	View protein in SMART SM00238, BIR, 3 hits SM00114, CARD, 1 hit SM00184, RING, 1 hit
SUPFAMⁱ	SSF47986, SSF47986, 1 hit
PROSITEⁱ	View protein in PROSITE PS01282, BIR_REPEAT_1, 3 hits PS50143, BIR_REPEAT_2, 3 hits PS50209, CARD, 1 hit PS50089, ZF_RING_2, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A2J8XX36_PONAB
Accessionⁱ	A0A2J8XX36Primary (citable) accession number: A0A2J8XX36 Secondary accession number(s): H2NF28
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 25, 2018
	Last sequence update:	April 25, 2018
	Last modified:	February 10, 2021
	This is version 19 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A0A2J8XX36 (A0A2J8XX36_PONAB)

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Uncharacterized protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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Nucleus

Other locations

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

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<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

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Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

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Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ