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Protein

Palmitoyltransferase

Gene

ZDHHC12

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
PalmitoyltransferaseUniRule annotation (EC:2.3.1.225UniRule annotation)
Gene namesi
Name:ZDHHC12Imported
ORF Names:CR201_G0027568Imported
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalUniRule annotationAdd BLAST21
Transmembranei44 – 64HelicalUniRule annotationAdd BLAST21
Transmembranei142 – 167HelicalUniRule annotationAdd BLAST26
Transmembranei179 – 204HelicalUniRule annotationAdd BLAST26

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000023788

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 216DHHCInterPro annotationAdd BLAST120

Domaini

The DHHC domain is required for palmitoyltransferase activity.UniRule annotation

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1311 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00530000063074
KOiK18932
OMAiWPSGSWE
OrthoDBiEOG091G0SSK
TreeFamiTF329809

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A2J8UJR2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPWALLSPG VLVRTGHTVL TWGITLVLFL HDTELRQWEE QGELLLPLTF
60 70 80 90 100
LLLVLGSLLL YLAVSLMDPG YVNVQPQPQE ELKEEQTAMV PPAIPLRRCR
110 120 130 140 150
YCLVLQPLRA RHCRECRRCV RRYDHHCPWM ENCVGERNHP LFVVYLALQL
160 170 180 190 200
VVLLWGLYLA WSGLRFFQPW GLWLRSSGLL FATFLLLSLF SLVASLLLAS
210 220 230 240 250
HLYLVASNTT TWEFISSHRI TYLRQRPGNP FDRGLTRNLA HFFCGWPSGS
260
WETLWAEEEE EGSSPAV
Length:267
Mass (Da):30,770
Last modified:April 25, 2018 - v1
Checksum:iDCACE9952015C85F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H2PTK3H2PTK3_PONAB
Palmitoyltransferase
ZDHHC12
215Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABGA01387555 Genomic DNA No translation available.
NDHI03003456 Genomic DNA Translation: PNJ45508.1
NDHI03003456 Genomic DNA Translation: PNJ45509.1
RefSeqiXP_002820313.1, XM_002820267.3

Genome annotation databases

EnsembliENSPPYT00000033053; ENSPPYP00000023788; ENSPPYG00000019660
GeneIDi100451108
KEGGipon:100451108

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABGA01387555 Genomic DNA No translation available.
NDHI03003456 Genomic DNA Translation: PNJ45508.1
NDHI03003456 Genomic DNA Translation: PNJ45509.1
RefSeqiXP_002820313.1, XM_002820267.3

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000023788

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000033053; ENSPPYP00000023788; ENSPPYG00000019660
GeneIDi100451108
KEGGipon:100451108

Organism-specific databases

CTDi84885

Phylogenomic databases

eggNOGiKOG1311 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00530000063074
KOiK18932
OMAiWPSGSWE
OrthoDBiEOG091G0SSK
TreeFamiTF329809

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2J8UJR2_PONAB
AccessioniPrimary (citable) accession number: A0A2J8UJR2
Secondary accession number(s): K7ETB9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 25, 2018
Last sequence update: April 25, 2018
Last modified: September 12, 2018
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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