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Entry version 8 (31 Jul 2019)
Sequence version 1 (28 Mar 2018)
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Protein
Submitted name:

COL6A3 isoform 6

Gene

CR201_G0033097

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
COL6A3 isoform 6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CR201_G0033097Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9601 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501432746926 – 2575Sequence analysisAdd BLAST2550

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 217VWFAInterPro annotationAdd BLAST180
Domaini230 – 402VWFAInterPro annotationAdd BLAST173
Domaini422 – 598VWFAInterPro annotationAdd BLAST177
Domaini626 – 797VWFAInterPro annotationAdd BLAST172
Domaini829 – 1002VWFAInterPro annotationAdd BLAST174
Domaini1032 – 1205VWFAInterPro annotationAdd BLAST174
Domaini1231 – 1417VWFAInterPro annotationAdd BLAST187
Domaini1795 – 1974VWFAInterPro annotationAdd BLAST180
Domaini2012 – 2208VWFAInterPro annotationAdd BLAST197
Domaini2389 – 2483Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini2510 – 2560BPTI/Kunitz inhibitorInterPro annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1005 – 1027DisorderedSequence analysisAdd BLAST23
Regioni1434 – 1762DisorderedSequence analysisAdd BLAST329
Regioni2355 – 2384DisorderedSequence analysisAdd BLAST30
Regioni2471 – 2490DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1501 – 1517PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1525 – 1545PolyampholyteSequence analysisAdd BLAST21
Compositional biasi1684 – 1706PolyampholyteSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
1049829at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 1 hit
cd00109 KU, 1 hit
cd01481 vWA_collagen_alpha3-VI-like, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.40.50.410, 9 hits
4.10.410.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS
IPR041900 vWA_collagen_alpha3-VI-like
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391 Collagen, 3 hits
PF00014 Kunitz_BPTI, 1 hit
PF00092 VWA, 9 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00759 BASICPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00131 KU, 1 hit
SM00327 VWA, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 1 hit
SSF53300 SSF53300, 9 hits
SSF57362 SSF57362, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00280 BPTI_KUNITZ_1, 1 hit
PS50279 BPTI_KUNITZ_2, 1 hit
PS50853 FN3, 1 hit
PS50234 VWFA, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2J8TPQ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKHRHLPLV AVFCLFLSGF PTTHAQQQQA VIEVNKRDIV FLVDGSSALG
60 70 80 90 100
LANFNAIRDF IAKVIQRLEI GQDLIQVAVA QYADTVRPEF YFNTHPTKRE
110 120 130 140 150
VITAVRKMKP LDGSALYTGS ALDFVRNNLF TSSAGYRAAE GIPKLLVLIT
160 170 180 190 200
GGKSLDEISQ SAQELKRSSI MAFAIGNKGA DQAELKEIAF DSSLVFIPAE
210 220 230 240 250
FRAAPLQGML PGFLAPLRTL SGTPEESKRD ILFLFDGSAN LVGQFPVVRD
260 270 280 290 300
FLYKIIDELD VKPDGTRIAV AQYSDDVKVE SRFDEHQSKP EILNLVKRMK
310 320 330 340 350
IKTGKALNLG YALDYAQRYI FVKSAGSRIE DGVLQFLVLL VAGRSSDRVD
360 370 380 390 400
GPASNLKQSG VVPFIFQAKN ADPAELEQIV LSPAFILAAE SLPKIGDLQP
410 420 430 440 450
QIVNLLKSVH NGAPAPVSGE KDVVFLLDGS EGVRSGFPLL KEFVQRVVES
460 470 480 490 500
LDVGQDRVRV AVVQYSDRTR PEFYLNSYMN QQDVVNAVRQ LTLLGGPTPN
510 520 530 540 550
TGAALEFVLR NILVSSAGSR ITEGVPQLLI VLTADRSGDD VRNPSVVVKR
560 570 580 590 600
GGAVPIGIGI GNADITEMQT ISFIPDFAVA IPTFRQLGTV QQVISERVTQ
610 620 630 640 650
LTREELSRLQ PVLQPLPSPG VGGKRDVVFL IDGSQSAGPE FQYIRTLIER
660 670 680 690 700
LVDYLDVGFD TTRVAVIQFS DDPKVEFLLN AHSSKDEVQN AVQRLRPKGG
710 720 730 740 750
RQINVGSALE YVSRNIFKRP LGSRIEEGVP QFLVLISSGK SDDEVDDPAV
760 770 780 790 800
ELKQFGVAPF TIARNADQEE LVKISLSPEY VFSVSTFREL PSLEQKLLTP
810 820 830 840 850
ITTLTSEQIQ KLLASTRYPP PAVESDAADI VFLIDSSEGV RPDGFAHIRD
860 870 880 890 900
FVSRIVRRLN IGPSKVRVGV VQFSNDVFPE FYLKTYRSQA PVLDAIRRLR
910 920 930 940 950
LRGGSPLNTG KALEFVARNL FVKSAGSRIE DGVPQHLVLV LGGKSQDDVS
960 970 980 990 1000
RFAQVIRSSG IVSLGVGDRN IDRTELQTIT NDPRLVFTVR EFRELPNIEE
1010 1020 1030 1040 1050
RIMNSFGPSA ATPAPPGVDT PPPSRPEKKK ADIVFLLDGS INFRRDSFQE
1060 1070 1080 1090 1100
VLRFVSEIVD TVYEDGDSIQ VGLVQYNSDP TDEFFLKDFS TKRQIIDAIN
1110 1120 1130 1140 1150
KVVYKGGRHA NTRVGLEHLR VNHFVPEAGS RLDQRVPQIA FVITGGKSVE
1160 1170 1180 1190 1200
DAQDVSLALT QRGVKVFAVG VRNIDSEEVG KIASNSATAF RVGNVQELSE
1210 1220 1230 1240 1250
LSEQVLETLH DAMHETLCPG VTDAAKACNL DVILGFDGSR DQNVFVAQKG
1260 1270 1280 1290 1300
FESKVDAILN RISQMHRVSC SGGRSPTVRV SVVANTPSGP VEAFDFDEYQ
1310 1320 1330 1340 1350
PEMLEKFRNM RSQHPYVLTE DTLKVYQNKF RQSSPDSVKV VIHFTDGADG
1360 1370 1380 1390 1400
DLADLHRASE NLRQEGVHAL ILVGLERVAN LERLMHLEFG RGFMYDRPLR
1410 1420 1430 1440 1450
LNLLDLDYEL AEQLDNIAEK ACCGVPCKCS GQRGDRGPIG SIGPKGIPGE
1460 1470 1480 1490 1500
DGYRGYPGDE GGPGERGPPG VNGTQGFQGC PGQRGVKGSR GFPGEKGEVG
1510 1520 1530 1540 1550
EIGLDGLDGE DGDKGLPGSS GEKGNPGRRG DKGPRGEKGE RGDVGIRGDP
1560 1570 1580 1590 1600
GNPGQDSQER GPKGETGDLG PMGVPGRDGV PGGPGETGKN GGFGRRGPPG
1610 1620 1630 1640 1650
AKGNKGGSGQ PGFEGEQGTR GAQGPAGPAG PPGLIGEQGI SGPRGSGGAA
1660 1670 1680 1690 1700
GAPGERGRTG PLGRKGEPGE PGPKGGIGNR GPRGETGDDG RDGVGSEGRR
1710 1720 1730 1740 1750
GKKGERGFPG YPGPKGNPGE PGLNGTTGPK GIRGRRGNSG PPGIVGQKGD
1760 1770 1780 1790 1800
PGYPGPAGPK GNRGDSIDQC ALIQSIKDKC PCCYGPLECP VFPTELAFAL
1810 1820 1830 1840 1850
DTSEGVNQDT FGRMRDVVLS IVNDLTIAES NCPRGARVAV VTYNNEVTTE
1860 1870 1880 1890 1900
IRFADSKRKS VLLDKIKNLQ VALTSKQQSL ETAMSFVARN TFKRVRNGFL
1910 1920 1930 1940 1950
MRKVAVFFSN TPTRASPQLR EAVLKLSDAG ITPLFLTSQE DRQLINALQI
1960 1970 1980 1990 2000
NNTAVGHALV LPAGRDLTDF LENVLTCHVC LDICNIDPSC GFGSWRPSFR
2010 2020 2030 2040 2050
DRRAAGSDVD IDMAFVLDSA ETTTLFQFNE MKKYIAYLVR QLDMSPDPKA
2060 2070 2080 2090 2100
SQHFARVAVV QHAPSESMGN ASMPPVKVEF SLTDYGSKEK LVDFLSRGMT
2110 2120 2130 2140 2150
QLQGTRALGS AIEYTIENVF ESAPNPRDLK IVVLMLTGEV QEQQLEEAQR
2160 2170 2180 2190 2200
VILQAKCKGY FFVVLGIGRK VNIKEVYTFA SEPNDVFFKL VDKSTELNEE
2210 2220 2230 2240 2250
PLMRFGRLLP SFVSSENAFY LSPDIRKQCD WFQGDQPTKN LVKFGHKQVN
2260 2270 2280 2290 2300
VPNNVTSSPT SNPAMTTKPV TTMKPVTTTT KPVTTTTKPV AIVNQPSAKP
2310 2320 2330 2340 2350
AAAKPAPVKP APAKPMAAKP VATKTATVRP PVVVKPATAA KPVAAKPAAV
2360 2370 2380 2390 2400
RPPAAAAAKP VVTKPEAPRP QAAKPAATKP ATTKPVVRVS REVQVFEITE
2410 2420 2430 2440 2450
NSAKLHWERP EPPSPYFYDL TVTSAHDQSL VLKQNLTVTD RIIGGLLAGQ
2460 2470 2480 2490 2500
TYHVAVVCYL RSQVRATYHG SFSTKKSQPP PPQPARSASS STINLMVSTE
2510 2520 2530 2540 2550
PLALTETDIC KLPKDEGTCR DFILKWYYDP NTKSCARFWY GGCGGNENKF
2560 2570
GSQKECEKVC APVLAKPGVI SVMGT
Length:2,575
Mass (Da):278,616
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB88C735707A6F2B7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
NDHI03003487 Genomic DNA Translation: PNJ34996.1

NCBI Reference Sequences

More...
RefSeqi
XP_009236561.1, XM_009238286.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100459849

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NDHI03003487 Genomic DNA Translation: PNJ34996.1
RefSeqiXP_009236561.1, XM_009238286.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100459849

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1293

Phylogenomic databases

OrthoDBi1049829at2759

Family and domain databases

CDDicd00063 FN3, 1 hit
cd00109 KU, 1 hit
cd01481 vWA_collagen_alpha3-VI-like, 3 hits
Gene3Di2.60.40.10, 1 hit
3.40.50.410, 9 hits
4.10.410.10, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS
IPR041900 vWA_collagen_alpha3-VI-like
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01391 Collagen, 3 hits
PF00014 Kunitz_BPTI, 1 hit
PF00092 VWA, 9 hits
PRINTSiPR00759 BASICPTASE
SMARTiView protein in SMART
SM00131 KU, 1 hit
SM00327 VWA, 9 hits
SUPFAMiSSF49265 SSF49265, 1 hit
SSF53300 SSF53300, 9 hits
SSF57362 SSF57362, 1 hit
PROSITEiView protein in PROSITE
PS00280 BPTI_KUNITZ_1, 1 hit
PS50279 BPTI_KUNITZ_2, 1 hit
PS50853 FN3, 1 hit
PS50234 VWFA, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2J8TPQ5_PONAB
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2J8TPQ5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: July 31, 2019
This is version 8 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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