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Protein

General transcription factor IIH subunit 4

Gene

GTF2H4

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIH subunit 4UniRule annotation
Gene namesi
Name:GTF2H4Imported
ORF Names:CR201_G0042356Imported
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000018363

Structurei

3D structure databases

SMRiA0A2J8SJA2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3471 Eukaryota
COG5144 LUCA
GeneTreeiENSGT00390000014159
KOiK03144
OMAiYLEQYAH
OrthoDBiEOG091G06YE
TreeFamiTF300879

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2J8SJA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESTPSRGLN RVHLQCRNLQ EFLGGLSPGV LDRLYGHPAT CLAVFRELPS
60 70 80 90 100
LAKNWVMRML FLEQPLPQAA VALWVKKEFS KAQEESTGLL SGLRIWHTQL
110 120 130 140 150
LPGGLQGLIL NPIFRQNLRI ALLGGGKAWS DDTSQLGPDK HARDVPSLDK
160 170 180 190 200
YAEERWEVVL HFMVGSPSAA VSQDLAQLLS QAGLMKSTEP GEPPCITSAG
210 220 230 240 250
FQFLLLDTPA QLWYFMLQYL QTAQSRGMDL VEILSFLFQL SFSTLGKDYS
260 270 280 290 300
VEGMSDSLLN FLQHLREFGL VFQRKRKSRR YYPTRLAINL SSGVSGAGGT
310 320 330 340 350
VHQPGFIVVE TNYRLYAYTE SELQIALIAL FSEMLYRFPN MVVAQVTRES
360 370 380 390 400
VQQAIASGIT AQQIIHFLRT RAHPVMLKQT PVLPPTITDQ IRLWELERDR
410 420 430 440 450
LRFTEGVLYN QFLSQVDFEL LLAHARELGV LVFENSAKRL MVVTPAGHSD
460
VKRFWKRQKH SS
Length:462
Mass (Da):52,186
Last modified:April 25, 2018 - v1
Checksum:i5532DAD617CA743C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABGA01234895 Genomic DNA No translation available.
NDHI03003564 Genomic DNA Translation: PNJ20851.1
NDHI03003564 Genomic DNA Translation: PNJ20852.1
RefSeqiXP_002816695.1, XM_002816649.2
XP_009239897.1, XM_009241622.1

Genome annotation databases

EnsembliENSPPYT00000019097; ENSPPYP00000018363; ENSPPYG00000016423
GeneIDi100445828
KEGGipon:100445828

Similar proteinsi

Entry informationi

Entry nameiA0A2J8SJA2_PONAB
AccessioniPrimary (citable) accession number: A0A2J8SJA2
Secondary accession number(s): H2PIG6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 25, 2018
Last sequence update: April 25, 2018
Last modified: June 20, 2018
This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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