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Entry version 11 (12 Aug 2020)
Sequence version 1 (28 Mar 2018)
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Protein
Submitted name:

ZNF106 isoform 6

Gene

CR201_G0046013

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ZNF106 isoform 6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CR201_G0046013Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9601 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000236516 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1527 – 1815WD_REPEATS_REGIONInterPro annotationAdd BLAST289
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1527 – 1566WDPROSITE-ProRule annotationAdd BLAST40
Repeati1567 – 1611WDPROSITE-ProRule annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni39 – 162DisorderedSequence analysisAdd BLAST124
Regioni321 – 356DisorderedSequence analysisAdd BLAST36
Regioni389 – 531DisorderedSequence analysisAdd BLAST143
Regioni555 – 647DisorderedSequence analysisAdd BLAST93
Regioni880 – 945DisorderedSequence analysisAdd BLAST66
Regioni958 – 1048DisorderedSequence analysisAdd BLAST91
Regioni1121 – 1143DisorderedSequence analysisAdd BLAST23
Regioni1182 – 1216DisorderedSequence analysisAdd BLAST35
Regioni1252 – 1376DisorderedSequence analysisAdd BLAST125
Regioni1389 – 1423DisorderedSequence analysisAdd BLAST35
Regioni1435 – 1483DisorderedSequence analysisAdd BLAST49
Regioni1502 – 1527DisorderedSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi69 – 86PolyampholyteSequence analysisAdd BLAST18
Compositional biasi97 – 113PolyampholyteSequence analysisAdd BLAST17
Compositional biasi126 – 142PolyampholyteSequence analysisAdd BLAST17
Compositional biasi321 – 338PolarSequence analysisAdd BLAST18
Compositional biasi389 – 427PolarSequence analysisAdd BLAST39
Compositional biasi458 – 497PolarSequence analysisAdd BLAST40
Compositional biasi510 – 531PolarSequence analysisAdd BLAST22
Compositional biasi563 – 600PolyampholyteSequence analysisAdd BLAST38
Compositional biasi601 – 618PolarSequence analysisAdd BLAST18
Compositional biasi619 – 635PolyampholyteSequence analysisAdd BLAST17
Compositional biasi882 – 910PolarSequence analysisAdd BLAST29
Compositional biasi958 – 1010PolarSequence analysisAdd BLAST53
Compositional biasi1258 – 1272PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1273 – 1316PolarSequence analysisAdd BLAST44
Compositional biasi1402 – 1421PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1440 – 1454PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1455 – 1483PolarSequence analysisAdd BLAST29

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

WD repeatPROSITE-ProRule annotationARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
IPR042622, Znf106
IPR013087, Znf_C2H2_type

The PANTHER Classification System

More...
PANTHERi
PTHR14435, PTHR14435, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400, WD40, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 6 hits
SM00355, ZnF_C2H2, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082, WD_REPEATS_2, 2 hits
PS50294, WD_REPEATS_REGION, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2J8S5L3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVGRIECPS SPSFPRDISH ECRVCGVTEV GLSAYAKHIS GQLHKDNVDA
60 70 80 90 100
QEREDDGKGE EEEEDYFDKE LVQLIKQRKE QSRQDEPSNS NQEINSDDRR
110 120 130 140 150
PQWRREDRIP YQDRESYSQP AWHHRGPPQR DWKWEKDGFN NTRKNSFPHS
160 170 180 190 200
LRNGGGPRGR SGWHKGVAGG SSTWFHNHSN SGGGWLSNSG TVDWNHNGTG
210 220 230 240 250
RNSSWLSEGT GGFSSWHMNN SNGKWKSSVR STNNWNYSGP GDKFQPGRNR
260 270 280 290 300
NSNCQMEDVT MLWNKKSNKS NKYSHDRYNW QRQENDKLGT VATYRGPSEG
310 320 330 340 350
FTSDKFPSEG LLDFNFEQAE SQTTKQADTA TSKVSGKNGS AAREKPRRWT
360 370 380 390 400
PYPSQKTLDL QSGLKDVTGN KPEMIEKPLF DFSLITTGIQ EPQTDETRNS
410 420 430 440 450
PTQKTQKEIH TGSLNHKASS DSANSFEVVR QCPIAEKPEQ EHTPNKMPSL
460 470 480 490 500
KSPLLPCPAT KSLSQKQDPK NISKNTKTNF FSPGEHSNPS NKPTAEDNHG
510 520 530 540 550
PYISKLRSSS PHVLKGNKST FGSQKQSGDN LNDTLRKAKE VLQCHESLQN
560 570 580 590 600
PVLSTSKRTR NYAKASRNVE ESEKGSLKIE FQVHALEDES DGETSDTEKH
610 620 630 640 650
GTKIGTLGSA TTELLSGSAR TADEKEEDDR ILKTSRELST SPCNPTACQK
660 670 680 690 700
ESELQMTSAA SPHPGLLLDL KTSLEDAQVD DSIKSHVSYE TEGFESTSLD
710 720 730 740 750
AELQKSDISQ PSGPLLPELS KLGFPASLQR DLTRHISLKS KTGVHLPEPN
760 770 780 790 800
LNSARRIRNI SGHRKSETEK ESGLKPTLRQ ILNASRRNVN WEQVIQQVTK
810 820 830 840 850
KKQELGKGLP RFGIEMVPLV QNEQEALDLD GEPDLSSLEG FQWEGVSISS
860 870 880 890 900
SPGLARKRSL SESSVIMDRA PSVYSFFSEE GTGKENEPQQ MISPSNSLRA
910 920 930 940 950
GQSQKATMHL KQEVTPRAAS LRTGERAENV ATQRRHSAQL PSDHIIPLMH
960 970 980 990 1000
LAKGLNSQER SIPPSENQNS QESNGEGNSL SSNSSSALAI SSLADAATDS
1010 1020 1030 1040 1050
SCTSGAEQND GQSIRKKRRA TGDGSSPELP SLERKNKRRK IKGKKERSQV
1060 1070 1080 1090 1100
DQLLNISLRE EELSKSLQCM DNNLLQARAA LQTAYVEVQR LLMLKQQITM
1110 1120 1130 1140 1150
EMSALRTHRI QILQGLQETY EPSEHPDQVP CSLTRERRNS RSQTSIDAAL
1160 1170 1180 1190 1200
LPTPFFPLFL EPPSSHVSPS PTGASLQITT SPTFQTHGSV PAPDSSVQIK
1210 1220 1230 1240 1250
QEPMSPEQDE NVNAVPPSSV CNVSKELLEA NREISDSCPV YPVITARLSL
1260 1270 1280 1290 1300
SESTESFHEP SQELKFSVEQ RNTRNRENSP SSQSAGLSSI NKEGEEPTKG
1310 1320 1330 1340 1350
NSGSEACTSS FLRLSFASET PLEKEPHSPA DQPEQQAEST LTSAETRGSK
1360 1370 1380 1390 1400
KKKKLRKKKS LRAAHVPENS DTEQDVLTVK PVRKVKAGKL IKGGKVTTST
1410 1420 1430 1440 1450
WEDSRTGREQ ESVRDEPDSD SSLEVLEIPN AQLEVVAIDS SESGEEKPDS
1460 1470 1480 1490 1500
PSKKDIWNST EQNPLETSRS GCDEVSSTSE IGTRYKDGIP VSVAETQTVI
1510 1520 1530 1540 1550
SSIKGSKNSS EISSEPGDDD EPTEGSFEGH QAAVNAIQIF GNLLYTCSAD
1560 1570 1580 1590 1600
KTVRVYNLVS RKCIGVFEGH TSKVNCLLVT QTSGKNAALY TGSSDHTIRC
1610 1620 1630 1640 1650
YNVKSRECVE QLQLEDRVLC LHSRWRILYA GLANGTVVTF NIKNNKRLEI
1660 1670 1680 1690 1700
FECHGPRAVS CLATAQEGAR KLLVVGSYDC TISVRDARNG LLLRTLEGHS
1710 1720 1730 1740 1750
KTILCMKVVN DLVFSGSSDQ SVHAHNIHTG ELVRIYKGHN HAVTVVNILG
1760 1770 1780 1790 1800
KVMVTACLDK FVRVYELQSH DRLQVYGGHK DMIMCMTIHK SMIYTGCYDG
1810 1820 1830 1840 1850
SIQAVRLNLM QNYRCWWHGC SLIFGVVDHL KQHLLTDHTN PNFQTLKCRW
1860 1870 1880
KNCDAFFTAR KGSKQDAAGH IERHAEDDSK IDS
Length:1,883
Mass (Da):208,793
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i894AD6D6E6B955C9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
NDHI03003606 Genomic DNA Translation: PNJ16056.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NDHI03003606 Genomic DNA Translation: PNJ16056.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
IPR042622, Znf106
IPR013087, Znf_C2H2_type
PANTHERiPTHR14435, PTHR14435, 1 hit
PfamiView protein in Pfam
PF00400, WD40, 2 hits
SMARTiView protein in SMART
SM00320, WD40, 6 hits
SM00355, ZnF_C2H2, 3 hits
SUPFAMiSSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082, WD_REPEATS_2, 2 hits
PS50294, WD_REPEATS_REGION, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2J8S5L3_PONAB
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2J8S5L3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: August 12, 2020
This is version 11 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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