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Entry version 4 (05 Jun 2019)
Sequence version 1 (28 Mar 2018)
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Protein
Submitted name:

SIPA1L3 isoform 1

Gene

CR201_G0051535

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activationPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SIPA1L3 isoform 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CR201_G0051535Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9601 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini609 – 826Rap-GAPInterPro annotationAdd BLAST218
Domaini964 – 1028PDZInterPro annotationAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni45 – 195DisorderedSequence analysisAdd BLAST151
Regioni236 – 330DisorderedSequence analysisAdd BLAST95
Regioni1044 – 1075DisorderedSequence analysisAdd BLAST32
Regioni1090 – 1221DisorderedSequence analysisAdd BLAST132
Regioni1234 – 1502DisorderedSequence analysisAdd BLAST269
Regioni1519 – 1565DisorderedSequence analysisAdd BLAST47
Regioni1580 – 1632DisorderedSequence analysisAdd BLAST53
Regioni1678 – 1710DisorderedSequence analysisAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1723 – 1771Sequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi45 – 69PolarSequence analysisAdd BLAST25
Compositional biasi81 – 95PolyampholyteSequence analysisAdd BLAST15
Compositional biasi96 – 134PolarSequence analysisAdd BLAST39
Compositional biasi171 – 187PolyampholyteSequence analysisAdd BLAST17
Compositional biasi272 – 289PolyampholyteSequence analysisAdd BLAST18
Compositional biasi300 – 325PolyampholyteSequence analysisAdd BLAST26
Compositional biasi1090 – 1113PolarSequence analysisAdd BLAST24
Compositional biasi1191 – 1215PolarSequence analysisAdd BLAST25
Compositional biasi1258 – 1282PolarSequence analysisAdd BLAST25
Compositional biasi1300 – 1322PolarSequence analysisAdd BLAST23
Compositional biasi1376 – 1390PolarSequence analysisAdd BLAST15
Compositional biasi1418 – 1449PolarSequence analysisAdd BLAST32
Compositional biasi1531 – 1552PolarSequence analysisAdd BLAST22
Compositional biasi1605 – 1619PolarSequence analysisAdd BLAST15

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.11210, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
IPR031204 SIPA1L3
IPR021818 SIPA1L_C

The PANTHER Classification System

More...
PANTHERi
PTHR15711:SF15 PTHR15711:SF15, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02145 Rap_GAP, 1 hit
PF11881 SPAR_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111347 SSF111347, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106 PDZ, 1 hit
PS50085 RAPGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2J8RE97-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTYRAIPSD GVDLAASCGA RAGDVLPGPH TGDYAPLGFW AQNGSMSQPL
60 70 80 90 100
GESPATATAT ASTRPSPTTP LMPKMGVRAR VADWPPKREA LREHSNPSPS
110 120 130 140 150
QDTDSTKATK MAHSMRSIQN GQPPTSTPAS SGSKAFYRLS RRRSKDVEFQ
160 170 180 190 200
DGWPRSPGRA FLPLRHRSSS EITLSECDAE DAGEPRGTRH TGALPLFREY
210 220 230 240 250
GSTSSIDVQG MPEQSFFDIL NEFRSEQPDA RGCQALTELL RADPGPHLMG
260 270 280 290 300
GGGGAKGDSH NGQPAKDSLL PLQPTKEKEK ARKKPARGLG GGDTVDSSIF
310 320 330 340 350
RKLRSSKPEG EAGRSPGEAD EGRSPPEASR PWVCQKSFAH FDVQSMLFDL
360 370 380 390 400
NEAAANRVSV SQRRNTTTGA SAASAASAMA SLTASRAHSL GGLDPAFTST
410 420 430 440 450
EDLNCKENLE QDLGDDNSND LLLSCPHFRN EIGGECERNV SFSRASVGSP
460 470 480 490 500
SIGEGHLAEP ALSAYRTNAS ISVLEVPKEQ QRTQSRPRQY SIEHVDLGAR
510 520 530 540 550
YYQDYFVGKE HANYFGVDEK LGPVAVSIKR EKLEDHKEHG PQYQYRIIFR
560 570 580 590 600
TRELITLRGS ILEDATPTAT KHGTGRGLPL KDALEYVIPE LNIHCLRLAL
610 620 630 640 650
STPKVTEQLL KLDEQGLCRK HKVGILYCKA GQSSEEEMYN NEEAGPAFEE
660 670 680 690 700
FLSLIGEKVC LKGFTKYAAQ LDVKTDSTGT HSLYTTYQDY EIMFHVSTLL
710 720 730 740 750
PYTPNNRQQL LRKRHIGNDI VTIIFQEPGA LPFTPKNIRS HFQHVFIIVR
760 770 780 790 800
VHNPCTDNVC YSMAVTRSKD APPFGPPIPS GTTFRKSDVF RDFLLAKVIN
810 820 830 840 850
AENAAHKSDK FHTMATRTRQ EYLKDLAENC VSNTPIDSTG KFNLISLTSK
860 870 880 890 900
KKEKTKARAG AEQHSAGAIA WRVAAQDYAQ GVEIDCILGI SNEFVVLLDL
910 920 930 940 950
RTKEVVFNCY CGDVIGWTPD SSTLKIFYGR GDHIFLQATE GSVEDIREIV
960 970 980 990 1000
QRLKVMTNGW ETVDMTLRRN GLGQLGFHVK YDGTVAEVED YGFAWQAGLR
1010 1020 1030 1040 1050
QGSRLVEICK VAVVTLTHDQ MIDLLRTSVT VKVVIIPPFE DGTPRRGWPE
1060 1070 1080 1090 1100
TYDMNTSEPK MEQESITPGG RPPYRSNALW QWSGPASHNS LPASKWATPT
1110 1120 1130 1140 1150
TPGHAQSLSR PPKQTPIVPF RESQPLHSKR PVSFPETPYT VSPAGADRVP
1160 1170 1180 1190 1200
PYRQPSGSFS TPGSATYVRY KPSPERYTAA PHPLLSLDPH FSHDGTSSGD
1210 1220 1230 1240 1250
SSSGGLTSQE STMERQKPEP LWHVPAQTRL SAIAGSSGNK HPSRQDAAGK
1260 1270 1280 1290 1300
DSPNRHSKGE PQYSSHSSSN TLSSNASSSH SDDRWFDPLD PLEPEQDPLS
1310 1320 1330 1340 1350
KGGSSDSGID TTLYTSSPSC MSLAKAPRPA KPHKPPGSMG LCGGGREAAG
1360 1370 1380 1390 1400
RSHHTDRRRE VSPAPAVAGQ SKGYRPKLYS SGSSTPTGLA GGSRDPPRQP
1410 1420 1430 1440 1450
SDMGSRVGYP AQVYKTASAE TPRPSQLAQP SPFQLSASVP KSFFSKQPVR
1460 1470 1480 1490 1500
NKHPTGWKRT EEPPPRPLPF SDPKKQVDTN TKNVFGQPRL RASLRDLRSP
1510 1520 1530 1540 1550
RKNYKSTIED DLKKLIIMDN LGPEQERDAG QSPQKGLQRT LSDESLCSGR
1560 1570 1580 1590 1600
REPSFTSPAG LEPGLPSDVL FTSTCAFPSS TLPARRQHQH PHPPVGPGAT
1610 1620 1630 1640 1650
PATTSGFPEK KSTISASELS LADGRDRPLR RLDPGMMPLP DTAAGLEWSS
1660 1670 1680 1690 1700
LVNAAKAYEV QRAVSLFSLN DPALSPDIPP AHSPVHSHLS LERGPPTPRS
1710 1720 1730 1740 1750
TPTMSEEPPL DLTGKVYQLE VMLKQLHTDL QKEKQDKVVL QSEVASLRQN
1760 1770
NQRLQEESQA ASEQLRKFAE IFCREKKEL
Length:1,779
Mass (Da):194,660
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9BADDCDF8DD149BD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
NDHI03003707 Genomic DNA Translation: PNJ06845.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NDHI03003707 Genomic DNA Translation: PNJ06845.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
IPR031204 SIPA1L3
IPR021818 SIPA1L_C
PANTHERiPTHR15711:SF15 PTHR15711:SF15, 1 hit
PfamiView protein in Pfam
PF02145 Rap_GAP, 1 hit
PF11881 SPAR_C, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF111347 SSF111347, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50085 RAPGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2J8RE97_PONAB
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2J8RE97
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: June 5, 2019
This is version 4 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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