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Entry version 10 (02 Jun 2021)
Sequence version 1 (28 Mar 2018)
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Protein
Submitted name:

TCOF1 isoform 8

Gene

CK820_G0010087

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TCOF1 isoform 8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CK820_G0010087Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPan troglodytes (Chimpanzee)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9598 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000236370 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 38LisHInterPro annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni57 – 1288DisorderedSequence analysisAdd BLAST1232
Regioni1322 – 1488DisorderedSequence analysisAdd BLAST167

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi57 – 74Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi102 – 116Polar residuesSequence analysisAdd BLAST15
Compositional biasi140 – 174Polar residuesSequence analysisAdd BLAST35
Compositional biasi643 – 657Polar residuesSequence analysisAdd BLAST15
Compositional biasi667 – 681Polar residuesSequence analysisAdd BLAST15
Compositional biasi776 – 790Polar residuesSequence analysisAdd BLAST15
Compositional biasi828 – 843Polar residuesSequence analysisAdd BLAST16
Compositional biasi972 – 986Polar residuesSequence analysisAdd BLAST15
Compositional biasi1013 – 1033Polar residuesSequence analysisAdd BLAST21
Compositional biasi1098 – 1121Polar residuesSequence analysisAdd BLAST24
Compositional biasi1170 – 1184Polar residuesSequence analysisAdd BLAST15
Compositional biasi1193 – 1235Polar residuesSequence analysisAdd BLAST43
Compositional biasi1322 – 1353Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi1385 – 1426Basic and acidic residuesSequence analysisAdd BLAST42
Compositional biasi1441 – 1462Basic residuesSequence analysisAdd BLAST22
Compositional biasi1474 – 1488Basic residuesSequence analysisAdd BLAST15

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
DFPECDP

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006594, LisH
IPR017859, Treacle
IPR003993, Treacle_dom

The PANTHER Classification System

More...
PANTHERi
PTHR20787, PTHR20787, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03546, Treacle, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00667, LisH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50896, LISH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2J8NJI9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEARKRREL LPLIYHHLLR AGYVRAAREV KEQSGQKCFL AQPVTLLDIY
60 70 80 90 100
THWQQTSELG RKRKAEEDAA LQAKKTRVSD PISTSESSEE EEEAEAETAK
110 120 130 140 150
ATPRLASTNS SVLGADLPSS MKEKAKAETE KAGKTGNSMP HPATGKTVAN
160 170 180 190 200
LLSGKSPRKS AEPSANTTLV SETEEEGSVL AFGAAAKPGM VSAGQADSSS
210 220 230 240 250
EDTSSSSDET DVEGKPSVKP AQVKASSVST KESPARKAAP APGKVGDVTP
260 270 280 290 300
QVKGGALPPA KKAKKPEEES ESSEEGSESE EEAPAGTRSQ VKASEKILQV
310 320 330 340 350
RAASAPAKGT PGKGATPAPP GKAGAVASQT KAGKPEEDSE SSSEESSDSE
360 370 380 390 400
EETPAAKALL QAKASGKTSQ VGAASAPAKE SPRKGAAPAP PGKTGPAVAK
410 420 430 440 450
AQAGKREEDS QSSSEESDSE EEAPAQAKPS GKAPQVRAAS APAKESPRKG
460 470 480 490 500
TAPAPPRKTG PAAAQVQVGK QEEDSGSSSE ESDSDREALA AMNAAQVKPL
510 520 530 540 550
GKSPQVKPAS TMGMGPLGKG AGPVPPGKVG PATPSAQVGK WEEDSESSSE
560 570 580 590 600
ESSDSSDGEV PTAVAPAQEK SLGNILQAKP ASSPAKGPPQ KAGPVAVQVK
610 620 630 640 650
AEKPMDNSES SEESSDSADS EEAPAVMTAA QAKPALKIPQ TKACPKKTNT
660 670 680 690 700
TASAKVAPVR VGTQAPRKAG TATSPAGSSP AVAGGTQRPA EDSSSSEESD
710 720 730 740 750
SEEEKTGLAV TVGQAKSVGK GLQVKAASVP LKGSLGQGTA PVLPGKTGPT
760 770 780 790 800
VTQVKAEKQE DSESSEEESD SEEAAASPAQ VKTSVKKTQA KANPAAARAP
810 820 830 840 850
SAKGTISAPG KVVTAAAQVK QRSPSKVKPP VRNPQNSTVL ARGPASVPSV
860 870 880 890 900
GKAVATAARA QTGPEEDSGS SEEESDSEEE VETLAQAKPS GKTPQIRAAL
910 920 930 940 950
APAKESPRKG AAPTPPGKTG PSAAQAGKQD DSGSSSEESD SDGEAPAAVT
960 970 980 990 1000
SAQKDSNSKP ARSKTLAPAP PERNTEGSSE SSEEELPLTQ VIKPPLIFVD
1010 1020 1030 1040 1050
PNRSPAGPAA TPAQAQAAST PRKARASEST ARSSSSESED EDVIPATQCL
1060 1070 1080 1090 1100
TPGIRTNVVT MPTAHPRIAP KASMAGASSS KESSRISDGK KQEGPATQVD
1110 1120 1130 1140 1150
SAVGTLPATS PQSSSVQAKG TNKLRKPKLP EVQQATKAPE SSDDSEDSSD
1160 1170 1180 1190 1200
SSSGSEEDAE GPQGAKSAHT LVGPTPSRTE TLVEETAAES SEDDVVAPSQ
1210 1220 1230 1240 1250
SLLSGYMTPG LTPANSQASK ATPKLDSSPS VSSTLAAKDD PDGKQEAKPQ
1260 1270 1280 1290 1300
QAAGMLSPKT GGKEAASGTT PQKSRKPKKG AGNPQASTLA LQSNIAQCLL
1310 1320 1330 1340 1350
GQPWPLNEAQ VQASVVKVLT ELLEQERKKV VDTTKESSRK GWESRKRKLS
1360 1370 1380 1390 1400
GDQLAARTPR SKKKKKLGAR EGGEASVSPE KTSTTSKGKA KRDKASGDVK
1410 1420 1430 1440 1450
EKKGKGSLGS QGAKDEPEEE LQKGMGKVEG GDQSNPKSKK EKKKSDKRKK
1460 1470 1480
DKEKKEKKKK AKKASTKDSE SPSQKKKKKK KKTAEQTV
Length:1,488
Mass (Da):152,363
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B166DF6FC734A8C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
NBAG03000228 Genomic DNA Translation: PNI71940.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NBAG03000228 Genomic DNA Translation: PNI71940.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Phylogenomic databases

OMAiDFPECDP

Family and domain databases

InterProiView protein in InterPro
IPR006594, LisH
IPR017859, Treacle
IPR003993, Treacle_dom
PANTHERiPTHR20787, PTHR20787, 2 hits
PfamiView protein in Pfam
PF03546, Treacle, 4 hits
SMARTiView protein in SMART
SM00667, LisH, 1 hit
PROSITEiView protein in PROSITE
PS50896, LISH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2J8NJI9_PANTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2J8NJI9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: June 2, 2021
This is version 10 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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