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Entry version 5 (05 Jun 2019)
Sequence version 1 (28 Mar 2018)
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Protein
Submitted name:

ATXN2 isoform 2

Gene

CK820_G0015900

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ATXN2 isoform 2Imported
Submitted name:
ATXN2 isoform 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CK820_G0015900Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPan troglodytes (Chimpanzee)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9598 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini411 – 479LsmADInterPro annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 257DisorderedSequence analysisAdd BLAST257
Regioni461 – 956DisorderedSequence analysisAdd BLAST496
Regioni1139 – 1221DisorderedSequence analysisAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi49 – 69Pro-richSequence analysisAdd BLAST21
Compositional biasi161 – 194PolarSequence analysisAdd BLAST34
Compositional biasi211 – 234PolarSequence analysisAdd BLAST24
Compositional biasi461 – 490PolyampholyteSequence analysisAdd BLAST30
Compositional biasi506 – 547PolarSequence analysisAdd BLAST42
Compositional biasi579 – 604Pro-richSequence analysisAdd BLAST26
Compositional biasi662 – 683PolarSequence analysisAdd BLAST22
Compositional biasi692 – 709PolarSequence analysisAdd BLAST18
Compositional biasi733 – 783PolarSequence analysisAdd BLAST51
Compositional biasi786 – 805PolyampholyteSequence analysisAdd BLAST20
Compositional biasi806 – 820PolarSequence analysisAdd BLAST15
Compositional biasi821 – 843PolyampholyteSequence analysisAdd BLAST23
Compositional biasi844 – 893PolarSequence analysisAdd BLAST50
Compositional biasi894 – 911PolyampholyteSequence analysisAdd BLAST18
Compositional biasi912 – 934PolarSequence analysisAdd BLAST23
Compositional biasi1152 – 1197PolarSequence analysisAdd BLAST46
Compositional biasi1205 – 1221PolarSequence analysisAdd BLAST17

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009818 Ataxin-2_C
IPR033093 ATXN2
IPR010920 LSM_dom_sf
IPR009604 LsmAD_domain
IPR025852 SM_dom_ATX

The PANTHER Classification System

More...
PANTHERi
PTHR12854:SF11 PTHR12854:SF11, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF06741 LsmAD, 1 hit
PF07145 PAM2, 1 hit
PF14438 SM-ATX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01272 LsmAD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50182 SSF50182, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2J8MYR0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSAAAAPRS PAVATESRRF AAARWPGWRS LQRPARRSGR GGGGAAPGPY
60 70 80 90 100
PSAAPPPPGP GPPPSRQSSP PSASDCFGSN GNGGGAFRPG SRRLLGLGGP
110 120 130 140 150
PRPFVVLLLP LASPGAPPAA PTRASPLGAR ASPPRSGVSL ARPAPGCPRP
160 170 180 190 200
ACEPVYGPLT MSLKPQQQQQ QQQQQQQQQQ QQQQQQQQQQ PPPAAANVRK
210 220 230 240 250
PGGSGLLASP AAAPSPSSSS VSSSSATAPS SVVAATSGGG RPGLGRGRNS
260 270 280 290 300
NKGLPQSTIS FDGIYANMRM VHILTSVVGS KCEVQVKNGG IYEGVFKTYS
310 320 330 340 350
PKCDLVLDAA HEKSTESSSG PKREEIMESI LFKCSDFVVV QFKDMDSSYA
360 370 380 390 400
KRDAFTDSAI SAKVNGEHKE KDLEPWDAGE LTANEELEAL ENDVSNGWDP
410 420 430 440 450
NDMFRYNEEN YGVVSTYDSS LSSYTVPLER DNSEEFLKRE ARANQLAEEI
460 470 480 490 500
ESSAQYKARV ALENDDRSEE EKYTAVQRNS SEREGHSINT RENKYIPPGQ
510 520 530 540 550
RNREVISWGS GRQNSPRMGQ PGSGSMPSRS TSHTSDFNPN SGSDQRVVNG
560 570 580 590 600
GVPWPSPCPS PSSRPPSRYQ SGPNSLPPRA ATPTRPPSRP PSRPSRPPSH
610 620 630 640 650
PSAHGSPAPV STMPKRMSSE GPPRMSPKAQ RHPRNHRVSA GRGSISSGLE
660 670 680 690 700
FVSHNPPSEA ATPPVARTSP SGGTWSSVVS GVPRLSPKTH RPRSPRQNSI
710 720 730 740 750
GNTPSGPVLA SPQAGIIPTE AVAMPIPAAS PTPASPASNR AVTPSSEAKD
760 770 780 790 800
SRLQDQRQNS PAGNKENIKP NETSPSFSKA ENKGISPVVS EHRKQIDDLK
810 820 830 840 850
KFKNDFRLQP SSTSESMDQL LNKNREGEKS RDLIKDKIEP SAKDSFIENS
860 870 880 890 900
SSNCTSGSSK PNSPSISPSI LSNTEHKRGP EVTSQGVQTS SPACKQEKDD
910 920 930 940 950
KEEKKDAAEQ VRKSTLNPNA KEFNPRSFSQ PKPSTTPTSP RPQAQPSPSM
960 970 980 990 1000
VGHQQPTPVY TQPVCFAPNM MYPVPVSPGV QPLYPIPMTP MPVNQAKTYR
1010 1020 1030 1040 1050
AVPNMPQQRQ DQHHQSAMMH PASAAGPPIA ATPPAYSTQY VAYSPQQFPN
1060 1070 1080 1090 1100
QPLVQHVPHY QSQHPHVYSP VIQGNARMMA PPTHAQPGLV SSSATQYGAH
1110 1120 1130 1140 1150
EQTHAMYACP KLPYNKETSP SFYFAISTGS LAQQYAHPNA TLHPHTPHPQ
1160 1170 1180 1190 1200
PSATPTGQQQ SQHGGSHPAP SPVQHHQHQA AQALHLASPQ QQSAIYHAGL
1210 1220 1230 1240 1250
APTPPSMTPA SNTQSPQNSF PAAQQTVFTI HPSHVQPAYT NPPHMAHVPQ
1260 1270 1280 1290 1300
AHVQSGMVPS HPTAHAPMML MTTQPPGGPQ AALAQSALQP IPVSTTAHFP
1310
YMTHPSVQAH HQQQL
Length:1,315
Mass (Da):140,539
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i10FB2694A137146F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
NBAG03000240 Genomic DNA Translation: PNI64641.1
NBAG03000240 Genomic DNA Translation: PNI64642.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NBAG03000240 Genomic DNA Translation: PNI64641.1
NBAG03000240 Genomic DNA Translation: PNI64642.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR009818 Ataxin-2_C
IPR033093 ATXN2
IPR010920 LSM_dom_sf
IPR009604 LsmAD_domain
IPR025852 SM_dom_ATX
PANTHERiPTHR12854:SF11 PTHR12854:SF11, 1 hit
PfamiView protein in Pfam
PF06741 LsmAD, 1 hit
PF07145 PAM2, 1 hit
PF14438 SM-ATX, 1 hit
SMARTiView protein in SMART
SM01272 LsmAD, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2J8MYR0_PANTR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2J8MYR0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: June 5, 2019
This is version 5 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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