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Protein
Submitted name:

NR3C2 isoform 2

Gene

NR3C2

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi600 – 679Nuclear receptorPROSITE-ProRule annotationAdd BLAST80

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorSAAS annotation
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
NR3C2 isoform 2Imported
Submitted name:
NR3C2 isoform 6Imported
Submitted name:
Nuclear receptor subfamily 3 group C member 2Imported
Gene namesi
Name:NR3C2Imported
ORF Names:CK820_G0016888Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 4

Organism-specific databases

VGNCiVGNC:2971 NR3C2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSPTRG00000016499 Expressed in 6 organ(s), highest expression level in prefrontal cortex

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000057800

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini600 – 679Nuclear receptorInterPro annotationAdd BLAST80
Domaini730 – 968NR LBDInterPro annotationAdd BLAST239

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.SAAS annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00760000118887
OMAiSKICLVC
OrthoDBiEOG091G0166
TreeFamiTF106510

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A2J8MUF6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METKGYHSLP EGLDMERRWG QVSQAVEHSS LGPTERTDEN NYMEIVNVSC
60 70 80 90 100
VSGAIPNNST QGSSKEKHEL LPCLQQDNNR PGILTSDIKT ELESKELSAT
110 120 130 140 150
VAESMGLYMD SVRDADYSYE QQNQQGSMSP AKIYQNVEQL VKFYKGNGHR
160 170 180 190 200
PSTLSCVNRP LRSFMSDSGS SVNGGVMRAI VKSPIMCHEK SPSVCSPLNM
210 220 230 240 250
TSSVCSPAGI NSVSSTTASF GNFPVHSPIT QGTPLTCSPN VENRGSRSHS
260 270 280 290 300
PAHASNVGSP LSSPLSSMKS SISSPPSHCS VKSPVSSPNN VTLRSSVSSP
310 320 330 340 350
ANINNSRCSV SSPSNTNNRS TLSSPAASTV GSICSPVNNA FSYTASGTSA
360 370 380 390 400
GSSTLRDVVP SPDTQEKGAQ EVPFPKTEEV ESAISNGVTG QLNIVQYIKP
410 420 430 440 450
EPDGAFSSSC LGGNSKINSD SSFSVPIKQE STKHSCSGTS FKGNPTVNPF
460 470 480 490 500
PFMDGSYFSF MDDKDYYSLS GILGPPVPGF DGNCEGSGFP VGIKQEPDDG
510 520 530 540 550
SYYPEASIPS SAIVGVNSGG QSFHYRIGAQ GTISLSRSAR DQSFQHLSSF
560 570 580 590 600
PPVNTLVESW KSHGDLSSRR SDGYPVLEYI PENVSSSTLR SVSTGSSRPS
610 620 630 640 650
KICLVCGDEA SGCHYGVVTC GSCKVFFKRA VEGKCSWQHN YLCAGRNDCI
660 670 680 690 700
IDKIRRKNCP ACRLQKCLQA GMNLGARKSK KLGKLKGIHE EQPQQQQPPP
710 720 730 740 750
PPPPPQSPEE GTTYIAPAKE PSVNTALVPQ LSTISRALTP SPVMVLENIE
760 770 780 790 800
PEIVYAGYDS SKPDTAENLL STLNRLAGKQ MIQVVKWAKV LPGFKNLPLE
810 820 830 840 850
DQITLIQYSW MCLSSFALSW RSYKHTNSQF LYFAPDLVFN EEKMHQSAMY
860 870 880 890 900
ELCQGMHQIS LQFVRLQLTF EEYTIMKVLL LLSTIPKDGL KSQAAFEEMR
910 920 930 940 950
TNYIKELRKM VTKCPNNSGQ SWQRFYQLTK LLDSMHDLVS DLLEFCFYTF
960 970 980
RESHALKVEF PAMLVEIISD QLPKVESGNA KPLYFHRK
Length:988
Mass (Da):107,672
Last modified:April 25, 2018 - v1
Checksum:i0671F6368D8CA5E7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3S0X0A0A2I3S0X0_PANTR
NR3C2 isoform 4
NR3C2 CK820_G0016888
867Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04005018 Genomic DNA No translation available.
AACZ04005019 Genomic DNA No translation available.
AACZ04005020 Genomic DNA No translation available.
NBAG03000243 Genomic DNA Translation: PNI63148.1
NBAG03000243 Genomic DNA Translation: PNI63152.1
RefSeqiXP_009446675.1, XM_009448400.2
XP_009446676.1, XM_009448401.2
XP_009446677.1, XM_009448402.2
XP_016806539.1, XM_016951050.1

Genome annotation databases

EnsembliENSPTRT00000066224; ENSPTRP00000057800; ENSPTRG00000016499
GeneIDi461533

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04005018 Genomic DNA No translation available.
AACZ04005019 Genomic DNA No translation available.
AACZ04005020 Genomic DNA No translation available.
NBAG03000243 Genomic DNA Translation: PNI63148.1
NBAG03000243 Genomic DNA Translation: PNI63152.1
RefSeqiXP_009446675.1, XM_009448400.2
XP_009446676.1, XM_009448401.2
XP_009446677.1, XM_009448402.2
XP_016806539.1, XM_016951050.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000057800

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000066224; ENSPTRP00000057800; ENSPTRG00000016499
GeneIDi461533

Organism-specific databases

CTDi4306
VGNCiVGNC:2971 NR3C2

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00760000118887
OMAiSKICLVC
OrthoDBiEOG091G0166
TreeFamiTF106510

Gene expression databases

BgeeiENSPTRG00000016499 Expressed in 6 organ(s), highest expression level in prefrontal cortex

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2J8MUF6_PANTR
AccessioniPrimary (citable) accession number: A0A2J8MUF6
Secondary accession number(s): H2RCT2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 25, 2018
Last sequence update: April 25, 2018
Last modified: September 12, 2018
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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