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Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

CK820_G0051811

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

thiamine diphosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandPyruvateUniRule annotation, Thiamine pyrophosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alphaUniRule annotation (EC:1.2.4.1UniRule annotation)
Gene namesi
ORF Names:CK820_G0051811Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

Subcellular locationi

Structurei

3D structure databases

SMRiA0A2J8IZ76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 368E1_dhInterPro annotationAdd BLAST302

Family and domain databases

InterProiView protein in InterPro
IPR001017 DH_E1
IPR017597 Pyrv_DH_E1_asu_subgrp-y
IPR029061 THDP-binding
PfamiView protein in Pfam
PF00676 E1_dh, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
TIGRFAMsiTIGR03182 PDH_E1_alph_y, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2J8IZ76-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKMLAAVSR VLSGASQKPA SRVLVASRNF ANDATFEIKK CDLHRLEEGP
60 70 80 90 100
PVTTVLTRED GLKYYRMMQT VRRMELKADQ LYKQKIIRGF CHLCDGQFLL
110 120 130 140 150
PLTQEACCVG LEAGINPTDH LITAYRAHGF TFTRGLSVRE ILAELTGRKG
160 170 180 190 200
GCAKGKGGSM HMYAKNFYGG NGIVGAQVPL GAGIALACKY NGKDEVCLTL
210 220 230 240 250
YGDGAANQGQ IFEAYNMAAL WKLPCIFICE NNRYGMGTSV ERAAASTDYY
260 270 280 290 300
KRGDFIPGLR VDGMDILCVR EATRFAAAYC RSGKGPILME LQTYRYHGHS
310 320 330 340 350
MSDPGVSYRT REEIQEVRSK SDPIMLLKDR MVNSNLASVE ELKEIDVEVR
360 370 380 390
KEIEDAAQFA TADPEPPLEE LGYHIYSSDP PFEVRGANQW IKFKSVS
Length:397
Mass (Da):44,109
Last modified:March 28, 2018 - v1
Checksum:i4BE156001F9994A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NBAG03000549 Genomic DNA Translation: PNI15828.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NBAG03000549 Genomic DNA Translation: PNI15828.1

3D structure databases

SMRiA0A2J8IZ76
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR001017 DH_E1
IPR017597 Pyrv_DH_E1_asu_subgrp-y
IPR029061 THDP-binding
PfamiView protein in Pfam
PF00676 E1_dh, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
TIGRFAMsiTIGR03182 PDH_E1_alph_y, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2J8IZ76_PANTR
AccessioniPrimary (citable) accession number: A0A2J8IZ76
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: May 23, 2018
This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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