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Protein

Pantothenate synthetase

Gene

panC

Organism
Stenotrophomonas maltophilia (Pseudomonas maltophilia) (Xanthomonas maltophilia)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotationSAAS annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei38Proton donorUniRule annotation1
Binding sitei62Beta-alanineUniRule annotation1
Binding sitei62PantoateUniRule annotation1
Binding sitei156PantoateUniRule annotation1
Binding sitei179ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi31 – 38ATPUniRule annotation8
Nucleotide bindingi150 – 153ATPUniRule annotation4
Nucleotide bindingi187 – 190ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processPantothenate biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00028;UER00005

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
ORF Names:B9Y71_08660Imported
OrganismiStenotrophomonas maltophilia (Pseudomonas maltophilia) (Xanthomonas maltophilia)Imported
Taxonomic identifieri40324 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group
Proteomesi
  • UP000230986 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

SMRiA0A2J0U1A8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 21Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

CDDicd00560 PanC, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00158 PanC, 1 hit
InterProiView protein in InterPro
IPR003721 Pantoate_ligase
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR21299:SF1 PTHR21299:SF1, 1 hit
PfamiView protein in Pfam
PF02569 Pantoate_ligase, 1 hit
TIGRFAMsiTIGR00018 panC, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2J0U1A8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIQTFNELGA LREQIAQWKR EGLRVALVPT MGNLHGGHHS LVTLARQYAD
60 70 80 90 100
KVVASIFVNP TQFGPNEDFS RYPRTPEADV AGLEQVGCDA VWLPSVEAMY
110 120 130 140 150
PLGVDKTTQM HAPGVSEVLE GASRPGHFDG VCTVVARLFL QVQPDVAVFG
160 170 180 190 200
RKDYQQLAVI RQMVAELSFP IQIVGADIVR DEDGLAKSSR NQYLSAEQRP
210 220 230 240 250
VATTIHRTLL GMREGYVAGQ ARDRIEADAT AALQAAGFQV DYAVLRTPEL
260 270
AEPTFDGGGR VALIAARLGS TRLIDNLEF
Length:279
Mass (Da):30,428
Last modified:March 28, 2018 - v1
Checksum:i1828378CE41B1D6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NEQT01000013 Genomic DNA Translation: PJL20441.1
RefSeqiWP_012479762.1, NZ_NEQX01000002.1

Genome annotation databases

GeneIDi6394181

Similar proteinsi

Entry informationi

Entry nameiA0A2J0U1A8_STEMA
AccessioniPrimary (citable) accession number: A0A2J0U1A8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: June 20, 2018
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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