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Protein
Submitted name:

chordin isoform X3

Gene

chrd

Organism
Austrofundulus limnaeus
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental proteinPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
chordin isoform X3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:chrdImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAustrofundulus limnaeusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri52670 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesRivulidaeAustrofundulus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000192220 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini132 – 247CHRDInterPro annotationAdd BLAST116
Domaini249 – 370CHRDInterPro annotationAdd BLAST122
Domaini371 – 494CHRDInterPro annotationAdd BLAST124
Domaini500 – 627CHRDInterPro annotationAdd BLAST128
Domaini657 – 716VWFCInterPro annotationAdd BLAST60
Domaini735 – 804VWFCInterPro annotationAdd BLAST70

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
647180at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016353 Chordin
IPR010895 CHRD
IPR001007 VWF_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07452 CHRD, 3 hits
PF00093 VWC, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002496 Chordin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00754 CHRD, 4 hits
SM00214 VWC, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50933 CHRD, 4 hits
PS01208 VWFC_1, 3 hits
PS50184 VWFC_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A2I4CME1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYSSDEPEEE PAPVLPPSCS IATVTWEIED IIEHALQTEP DPGTGPPNRK
60 70 80 90 100
SSHQPPAGLL QPLAIPKRPW SHISIDFVTG FPLSKGTNDK KQTDPLLESF
110 120 130 140 150
EYFTEKGKED DLHKSYNDRS YLSSEDTGVG ESRTDFVALL TGVTDSWLPS
160 170 180 190 200
SSGVARARLS LTRTSITFSI TYLRFGRPGK LVFLDSDGTT AFEFKVPKGQ
210 220 230 240 250
SDMICGVWKN VPKPLLRQLQ SEQMHISMTT STGKREEIQG KIIKHRALFA
260 270 280 290 300
ETFSSVLTSD EDNSGMGGIA MLTLSDSENN LHFILILQGL IRHKDKEPIL
310 320 330 340 350
VPIRVQLMYR QHVLREVRAN ITSNDPDFAE VLTDLNSREL FWLSRGQLEI
360 370 380 390 400
VVATEDQDPR QILGFITGRK SCDTIQSVMS SGDALTPGKT GGVGSAVFNL
410 420 430 440 450
NDNGTLEYQV QVAGLSSDVV GLTIELKPRR RNKRSVLYDL TPEFSQTSGQ
460 470 480 490 500
AVGSWSRLEA RHIHMLLQNE LFINVATAHS QEGELRGQIK ALPYSGLEVP
510 520 530 540 550
RQGLPTPLAG HFLSPPVRTG ASGHAWVSVD KQCHLHYEIV VAGLSKKEDV
560 570 580 590 600
TVNAHLHGLA EIGELDNSST THKRLLTGFY GSQAQGILKD LSLELLQHLD
610 620 630 640 650
QGTAFIQVST KLNPQGEIRG RVHVPNSCES GAGAEVEEAE LDDTLLTDPE
660 670 680 690 700
ELKKDPNTCF FENQHHAHGS RWTPNYDKCF TCSCQKRTVI CDPVICPVLT
710 720 730 740 750
CSRTIQPEDK CCPICDEKRE PKDMKAGEKV EEHPEGCYFE GDQKMHAPGI
760 770 780 790 800
SWHPFVPPFG YIKCAVCTCK GSSGEVHCEK VTCPVLVCSH PVRRNPSDCC
810 820 830 840 850
KECPEEERTP AGLRHTDMMQ ADGPRHCKFG KNYYQNSDSW HPWVPLVGEM
860 870 880 890 900
KCINCWCDHG VTKCQRKQCA VLTCSNITRT ENSCCPECAD RRSADTGKDQ
910
ILIYTSTKIP KSKMT
Length:915
Mass (Da):101,525
Last modified:February 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6634C6CDDB8A644C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I4CMD2A0A2I4CMD2_9TELE
Chordin
chrd
974Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I4CME6A0A2I4CME6_9TELE
Chordin
chrd
969Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I4CMC8A0A2I4CMC8_9TELE
chordin isoform X4
chrd
851Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_013881148.1, XM_014025694.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
106530122

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_013881148.1, XM_014025694.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi106530122

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8646

Phylogenomic databases

OrthoDBi647180at2759

Family and domain databases

InterProiView protein in InterPro
IPR016353 Chordin
IPR010895 CHRD
IPR001007 VWF_dom
PfamiView protein in Pfam
PF07452 CHRD, 3 hits
PF00093 VWC, 3 hits
PIRSFiPIRSF002496 Chordin, 1 hit
SMARTiView protein in SMART
SM00754 CHRD, 4 hits
SM00214 VWC, 3 hits
PROSITEiView protein in PROSITE
PS50933 CHRD, 4 hits
PS01208 VWFC_1, 3 hits
PS50184 VWFC_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2I4CME1_9TELE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2I4CME1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: January 16, 2019
This is version 5 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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