Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 16 (12 Aug 2020)
Sequence version 1 (28 Feb 2018)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

MDS1 and EVI1 complex locus protein EVI1 isoform X1

Gene

mecom

Organism
Austrofundulus limnaeus
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MDS1 and EVI1 complex locus protein EVI1 isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mecomImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAustrofundulus limnaeusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri52670 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesRivulidaeAustrofundulus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000192220 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini74 – 186SETInterPro annotationAdd BLAST113
Domaini205 – 232C2H2-typeInterPro annotationAdd BLAST28
Domaini262 – 289C2H2-typeInterPro annotationAdd BLAST28
Domaini290 – 317C2H2-typeInterPro annotationAdd BLAST28
Domaini318 – 347C2H2-typeInterPro annotationAdd BLAST30
Domaini348 – 375C2H2-typeInterPro annotationAdd BLAST28
Domaini384 – 411C2H2-typeInterPro annotationAdd BLAST28
Domaini413 – 440C2H2-typeInterPro annotationAdd BLAST28
Domaini943 – 970C2H2-typeInterPro annotationAdd BLAST28
Domaini971 – 999C2H2-typeInterPro annotationAdd BLAST29
Domaini1000 – 1027C2H2-typeInterPro annotationAdd BLAST28

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni31 – 58DisorderedSequence analysisAdd BLAST28
Regioni221 – 247DisorderedSequence analysisAdd BLAST27
Regioni508 – 681DisorderedSequence analysisAdd BLAST174
Regioni723 – 767DisorderedSequence analysisAdd BLAST45
Regioni780 – 825DisorderedSequence analysisAdd BLAST46
Regioni1020 – 1047DisorderedSequence analysisAdd BLAST28
Regioni1063 – 1156DisorderedSequence analysisAdd BLAST94
Regioni1186 – 1205DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi34 – 58PolarSequence analysisAdd BLAST25
Compositional biasi568 – 588PolarSequence analysisAdd BLAST21
Compositional biasi595 – 615PolarSequence analysisAdd BLAST21
Compositional biasi617 – 641PolyampholyteSequence analysisAdd BLAST25
Compositional biasi808 – 825PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1026 – 1041PolarSequence analysisAdd BLAST16
Compositional biasi1098 – 1115AcidicSequence analysisAdd BLAST18
Compositional biasi1116 – 1145PolyampholyteSequence analysisAdd BLAST30

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K04462

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001214, SET_dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50280, SET, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 7 hits
PS50157, ZINC_FINGER_C2H2_2, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All

A0A2I4BZ76-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSKGRARKL ATSDDSDDFA LYPANILDDV CDSTGDPSLS STLAEDPLSD
60 70 80 90 100
DELSPQSIQQ PNMFIAQTDL AIPLDFELRE SAVPGAGLGI WSRRKVNIGE
110 120 130 140 150
RFGPFEGEHR PCLQDPAQGW EILDGSGHVK FCVDASKPDA GSWLKHIQFA
160 170 180 190 200
PAXSQHNLTA CQIDDQIFYK VTREIFPGEE LLLFMKAEEY PCDTMAPDIH
210 220 230 240 250
EERQYRCEDC DQNFESRSQL LDHQKQPCGM PPSSFLNPGG DSDLKAQEPQ
260 270 280 290 300
DLRPLHMSHG LHECKDCDQV FPDVQSLEAH ILSHSEEREY KCDQCPKAFN
310 320 330 340 350
WKSNLIRHQM SHDSGKHYEC ENCSKQVFTD PSNLQRHIRS QHVGARAHAC
360 370 380 390 400
SDCGKTFATS SGLKQHKHIH SSVKPFMCKS LRPYLCEVCH KSYTQFSNLC
410 420 430 440 450
RHKRMHADCR TQIKCKDCGQ MFSTTSSLNK HRRFCEGKNH FTAGGLFAQG
460 470 480 490 500
LPLPGTPGLD KSALAIGHTS AGLADYFGAS RHHTGLTFPA APAFPFSFPG
510 520 530 540 550
LFPSGLYHRP PLIPATTSPV RQPSHAPVAG PGSELCKSPL LPSSPSALES
560 570 580 590 600
QELLKALRKD GGSPGNQIPD SELHNQGSSS TTKQRNKQSD QSESSDLDDV
610 620 630 640 650
STPSGSDLES TTGSELESDL DSERERGAAR ENGKGPKRKG HEGGSQSPSF
660 670 680 690 700
IGSSAAKDFP GPSLIQSSLD EHTAVTGAVN DSIKAIASIA EKYFGSTGLA
710 720 730 740 750
SLQDKKVGSL PYPSMFSLPF FPAFSPPVYP FPDRDLRPTX LKGEPQSPGD
760 770 780 790 800
DGKKSQGKSS SESPFDLTTK RKAEKLVLFA SSKPEISHPT GEDQPLDLSL
810 820 830 840 850
GSRGRGRFSN QEEAKKSPGY EEEKRVLEIP KADSSLQHAR PTPFFMDPIY
860 870 880 890 900
SRVEKRRMSD PFETLKDKYM RPAPGFLFHP QFRLPDQRTW MTAIENMAEK
910 920 930 940 950
LETFGSLKSE SSELLRSVPS MFDFRAPPSA LPETLLRKGK ERYTCRYCGK
960 970 980 990 1000
IFPRSANLTR HLRTHTGEQP YRCKYCDRSF SISSNLQRHI RNIHNKEKPF
1010 1020 1030 1040 1050
KCHLCDRCFG QQTNLDRHLK KHENGNLSGT AMSSPQSELD SGSAILDDKE
1060 1070 1080 1090 1100
DSYFNEIRNF ISKAGQNHTS PDHSEEGLNG GPLEEGKPLM VSHGSQDLED
1110 1120 1130 1140 1150
EEVEDLDADD EEAEEPSNNS EKREPKVHSS SLSDDIIRDE MDFSEPNDLN
1160 1170 1180 1190 1200
FSCQTSPRRY KDEEELSHYS ALDRIHRFSD LRKLEESELS DGDGEEDDRA
1210 1220 1230 1240 1250
FDSPSLTEAV KQPLFRKSKS QAYAMMLSLA EKDSLHSATH TPATMWHSLA
1260
RAAAESSAIQ SLSHV
Length:1,265
Mass (Da):140,608
Last modified:February 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE292E40D7827143
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I4BZ74A0A2I4BZ74_9TELE
MDS1 and EVI1 complex locus protein...
mecom
1,264Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I4BZ77A0A2I4BZ77_9TELE
MDS1 and EVI1 complex locus protein...
mecom
1,257Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I4BZ80A0A2I4BZ80_9TELE
MDS1 and EVI1 complex locus protein...
mecom
1,264Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I4BZ81A0A2I4BZ81_9TELE
MDS1 and EVI1 complex locus protein...
mecom
1,255Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I4BZ82A0A2I4BZ82_9TELE
MDS1 and EVI1 complex locus protein...
mecom
1,255Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I4BZ83A0A2I4BZ83_9TELE
MDS1 and EVI1 complex locus protein...
mecom
1,256Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I4BZ85A0A2I4BZ85_9TELE
MDS1 and EVI1 complex locus protein...
mecom
1,246Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I4BZ87A0A2I4BZ87_9TELE
MDS1 and EVI1 complex locus protein...
mecom
1,256Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I4BZ88A0A2I4BZ88_9TELE
MDS1 and EVI1 complex locus protein...
mecom
1,248Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I4BZ90A0A2I4BZ90_9TELE
MDS1 and EVI1 complex locus protein...
mecom
1,247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_013873050.1, XM_014017596.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
106523993

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
alim:106523993

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_013873050.1, XM_014017596.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Genome annotation databases

GeneIDi106523993
KEGGialim:106523993

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2122

Phylogenomic databases

KOiK04462
OrthoDBi1318335at2759

Family and domain databases

InterProiView protein in InterPro
IPR001214, SET_dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 10 hits
SUPFAMiSSF57667, SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50280, SET, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 7 hits
PS50157, ZINC_FINGER_C2H2_2, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2I4BZ76_9TELE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2I4BZ76
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: August 12, 2020
This is version 16 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again