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Entry version 5 (16 Jan 2019)
Sequence version 1 (28 Feb 2018)
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Protein
Submitted name:

CDK5 regulatory subunit-associated protein 2

Gene

cdk5rap2

Organism
Austrofundulus limnaeus
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CDK5 regulatory subunit-associated protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cdk5rap2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAustrofundulus limnaeusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri52670 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesRivulidaeAustrofundulus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000192220 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 125Cnn_1NInterPro annotationAdd BLAST72

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili55 – 75Sequence analysisAdd BLAST21
Coiled coili98 – 125Sequence analysisAdd BLAST28
Coiled coili152 – 186Sequence analysisAdd BLAST35
Coiled coili212 – 239Sequence analysisAdd BLAST28
Coiled coili255 – 282Sequence analysisAdd BLAST28
Coiled coili292 – 312Sequence analysisAdd BLAST21
Coiled coili326 – 385Sequence analysisAdd BLAST60
Coiled coili389 – 423Sequence analysisAdd BLAST35
Coiled coili435 – 455Sequence analysisAdd BLAST21
Coiled coili463 – 575Sequence analysisAdd BLAST113
Coiled coili585 – 644Sequence analysisAdd BLAST60
Coiled coili652 – 711Sequence analysisAdd BLAST60
Coiled coili774 – 815Sequence analysisAdd BLAST42
Coiled coili860 – 887Sequence analysisAdd BLAST28
Coiled coili900 – 941Sequence analysisAdd BLAST42
Coiled coili1054 – 1095Sequence analysisAdd BLAST42
Coiled coili1106 – 1126Sequence analysisAdd BLAST21
Coiled coili1174 – 1204Sequence analysisAdd BLAST31
Coiled coili1295 – 1315Sequence analysisAdd BLAST21
Coiled coili1522 – 1552Sequence analysisAdd BLAST31
Coiled coili1591 – 1628Sequence analysisAdd BLAST38
Coiled coili1668 – 1702Sequence analysisAdd BLAST35
Coiled coili1889 – 1916Sequence analysisAdd BLAST28
Coiled coili2115 – 2135Sequence analysisAdd BLAST21
Coiled coili2146 – 2166Sequence analysisAdd BLAST21
Coiled coili2233 – 2253Sequence analysisAdd BLAST21
Coiled coili2319 – 2353Sequence analysisAdd BLAST35
Coiled coili2411 – 2449Sequence analysisAdd BLAST39
Coiled coili2477 – 2543Sequence analysisAdd BLAST67
Coiled coili2572 – 2592Sequence analysisAdd BLAST21
Coiled coili2613 – 2644Sequence analysisAdd BLAST32
Coiled coili2832 – 2859Sequence analysisAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
1046642at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012943 Cnn_1N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07989 Cnn_1N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2I4B2L4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRSDSVVGD DLTLPVDING SCRLPDSINA GENSTDSMTA PFLPDTMSPI
60 70 80 90 100
KALTMKDYEN QITALKKENF NLKLRIYFME ERMQQKCDDS TEDIFKTNIE
110 120 130 140 150
LKVELESMKR ELAEKQELLV SASKALESLA GRESGEPQRV RDQAQREMEA
160 170 180 190 200
LRDAFNKRIA DLEQCLRTAE EEVENMAAIA EQEKLRSINM EKQLQVLAPS
210 220 230 240 250
GAFTPAAVPK TIQDLQHTLQ EKDNIIEQLK INLKNQEALV LQKSSTDQET
260 270 280 290 300
DAPSAKQLSD LIAEKDQELK ALKEALHKEK DKTQPDQEKG NIMRLESINK
310 320 330 340 350
MLTEELNHIK NTGKDKTQPD QEKGNIMRLE SINKMLTEEL NHIKNTNENL
360 370 380 390 400
TKTLEDSENQ NKSLSVKLEE KENELDSEKK NALKRDKTIQ GLTQVLGKKE
410 420 430 440 450
KEIEELCQQI EDRDDALTKA REAAHKAQLQ KYQGAEEHQS LLMEKQTELA
460 470 480 490 500
QLQGEHHVKI LEAQKLQRGL DRKEQELADL QQTKDQLEVE LEDLQQQKKK
510 520 530 540 550
GDKALNDLNN HLKKLNGEMK ERESALEQQY QELLDQTKRK LQTHEATIQR
560 570 580 590 600
LTTTLADKEQ QLQEYINMIR DLEQSKSPGS NDSMLNKLRQ RLKEKENALE
610 620 630 640 650
QALDEKFAAV EEKDNEIHQL QLLLREKERD LDRLNNLLTH NEETINNFDS
660 670 680 690 700
VIKEKDVELQ HLANTLKNLQ RAKQDVEDNL NRSLREKDSI INQLQLSLEG
710 720 730 740 750
KSKDMEEMSE SMLNQSQTRE RDLAEQMGQR LKVTEAMLAE AVKARERLVA
760 770 780 790 800
DNESAVEGLL ATISSKDQLL KESAEHFNRM LSERAQEIQE LKKQLTEKQQ
810 820 830 840 850
ELANAEKQSS STAQKSYLET SELKALLAEK DSLIDKLLQR GQERDQFLAE
860 870 880 890 900
MSQKVEHDHV LELRQTIQIM QEQLDEREAE LSRRNSEDNQ ENYLPSKKTV
910 920 930 940 950
VVLKEELAQK TEALNKALKR ENELKISLAD LQSLLSELEG RSEGQAANIE
960 970 980 990 1000
SLTATLKTKE EIINVLHQRL GQGGHCRADN IQDCVIGSGV ERSLPELPQR
1010 1020 1030 1040 1050
ERTMIGGDSQ QETVPSFVVL QQEHEALNRA VRAEQQLYSS LVRTVKEQDS
1060 1070 1080 1090 1100
AQRLHALQLE LTAVQLLRQQ LEDSIKTNEE LRDDLEREIH KAKLREGMDL
1110 1120 1130 1140 1150
IDPKELESMK HQLEDAQRWN ASLQARLGAI QNRGGGVGGA NDSSETLSFI
1160 1170 1180 1190 1200
GDQTSYMSIC VGEGADDSLA QLSAQELKQK VLELQSLNSE LQSRLSQMEK
1210 1220 1230 1240 1250
SERDACEKEG KDLTSRSRYK QQLDEMQPLT HSDRAHIPDQ DKESQTDMDT
1260 1270 1280 1290 1300
GEMTSGHLMG DNNMNSWLTN LTDTKENTDL LPLHSLLTDC GSTSVVELRE
1310 1320 1330 1340 1350
ELLRLRSETA QLQGLLKEQK SAECKEKEST DISGNSSDEQ AELRKSLETL
1360 1370 1380 1390 1400
QAKPNHSFKD TKLLKERTEK KSNDVSDGET PLTSVSAADE MESPKHQCQS
1410 1420 1430 1440 1450
QGKRAKQLVT RHRAGVKSRL PVPVRPRIEG SISRQSLSYD QMQTETQQHL
1460 1470 1480 1490 1500
HLDNDFGSDQ ALQTDSDSAL ELHTSPSTAL RCTQTSCSPA GSDGGSEARM
1510 1520 1530 1540 1550
LEDRTQGESA LLTQLELLHQ ECQEKEVLIT KMSEQLADLE ELHAQLQEKE
1560 1570 1580 1590 1600
RLNCQYTKAL QAAQSTIAYL TACSLDNQGG FGSHAGSGGS VAELHSRCME
1610 1620 1630 1640 1650
LQSALQEKEE LNSQLIELLN MAEKAITTSH SQNMEPEARD LCLRIESALH
1660 1670 1680 1690 1700
QGGASSNTDS PRLAEESLHE LQRHADSLQE ALLEQSRLNA ELQEQLRAAN
1710 1720 1730 1740 1750
TAAQHGHMSD GVPLNGTTSR QRAATAELID EEETEEHPGT TRSFDDTSLN
1760 1770 1780 1790 1800
QQFSVLMNCF SAAESVVASL AAHCADNGSQ TSDKSVEISP DLQTHLHNLQ
1810 1820 1830 1840 1850
SVLLKRSQLA DPAHPKIKPE GSLTDLTEPE GLKLHQDLCL LYKAFRRHSQ
1860 1870 1880 1890 1900
RIADLQAGLQ EEKAHRRESE GRRTAQDAKG LPPNVQLQLE TLHKALREKK
1910 1920 1930 1940 1950
KACKTLEEKL ATALTKTPSP ETARKAPEQG DKSVQVDLQD LGYETSGKSE
1960 1970 1980 1990 2000
NDREESSSTD LEVGVNPSCS PFSLPTLLKH EHAAFSSTEN LDSTSSTPYP
2010 2020 2030 2040 2050
SSPALSSAKA SLKGLQVYDE FGVSEDPLQL QAQVRELKGQ LENQTKLVLQ
2060 2070 2080 2090 2100
MQSFLRRSSL CSDAAANTSD LLSIREHEIT QKVNHSPEKS GQLRKRNEAE
2110 2120 2130 2140 2150
NQPMKDRATR LDLDLDEEKT QNQNTSEQLQ QTRSRSTSPA RLDSLVQSQA
2160 2170 2180 2190 2200
RELSQLRQQI KESRRLGVLQ RRQLEELNKA LKDLLHANEV DHYMGEVIKG
2210 2220 2230 2240 2250
QLDKSLSLLD RLEGRLDKES HVENEDSAAL ELSHRLAKEL QEKNRLIQSL
2260 2270 2280 2290 2300
QSQIRGRSPS SHHSSHSDLF HSDLMSSSCR SSPSTLGGSH AHSHQNPADR
2310 2320 2330 2340 2350
MGAAEPPVGG AQEKGAPGHR DTASRLQGLQ RENGRLQEQL RGSEELNATL
2360 2370 2380 2390 2400
RSELDLHRSI MAQASSHHQE QEQGRDQEVS GSQPAAQKQD ADISSPQKAG
2410 2420 2430 2440 2450
EQPHMMDSGL LAEHLQEIRA LRQRLEESIR TNDRLREQLE RRLAEVEKDP
2460 2470 2480 2490 2500
AATNIFIHGN EEQGQLVNEV RYLWEQNQTL KEQLNTGSRD KQKENEKLRE
2510 2520 2530 2540 2550
TLARRTAKLE QSRKECEALK QENTRLQERL ERCSQENSLL QTSLCSSREE
2560 2570 2580 2590 2600
LQRLQGEVKL QRQQLSDSHH LLQSLRVELQ VYEKMKNESN VNNSSTETSQ
2610 2620 2630 2640 2650
QPVPSPSSGS VDLSELLSEI RHLRLQLERS IQTNTALRQK LEEQLLRGPN
2660 2670 2680 2690 2700
RSETININYL LSSPDEGGRS PGREGGDPLR HSFQSHHVHA SVLHGVERCT
2710 2720 2730 2740 2750
HSEVDGDSVR SSSCDSASAA PSRLVPGHRM WANRNGRHVL GLIEDYNALR
2760 2770 2780 2790 2800
KQISEGGKLS RSMDSQLQEC LLTLRQQSSE HEVIDRQHLT SLSSSTNTMQ
2810 2820 2830 2840 2850
QVLEEAGRLL KLLWRVSLPA AHNECSGSNQ QDELLKNEIT RLKNRLSQQE
2860 2870 2880 2890 2900
RMLSGAVKRL RTTNLLKEGM EKVIIDQLSL THGVLKKARG NLETNYCSLG
2910 2920
LKGLSGGPGE GGSSQRSVAD TTCTQPE
Length:2,927
Mass (Da):329,533
Last modified:February 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0693A12D9AFD009E
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_013862004.1, XM_014006550.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
106516279

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_013862004.1, XM_014006550.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi106516279

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55755

Phylogenomic databases

OrthoDBi1046642at2759

Family and domain databases

InterProiView protein in InterPro
IPR012943 Cnn_1N
PfamiView protein in Pfam
PF07989 Cnn_1N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2I4B2L4_9TELE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2I4B2L4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: January 16, 2019
This is version 5 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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