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Protein

DNA polymerase alpha subunit B

Gene

pola2

Organism
Austrofundulus limnaeus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA replicationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase alpha subunit BUniRule annotation
Gene namesi
Name:pola2Imported
OrganismiAustrofundulus limnaeusImported
Taxonomic identifieri52670 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesRivulidaeAustrofundulus
Proteomesi
  • UP000192220 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 249Pol_alpha_B_NInterPro annotationAdd BLAST228
Domaini345 – 551DNA_pol_E_BInterPro annotationAdd BLAST207

Sequence similaritiesi

Belongs to the DNA polymerase alpha subunit B family.UniRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR007185 DNA_pol_alpha/epsilon_bsu
IPR016722 DNA_pol_alpha_bsu
IPR013627 Pol_alpha_B_N
PANTHERiPTHR23061 PTHR23061, 1 hit
PfamiView protein in Pfam
PF04042 DNA_pol_E_B, 1 hit
PF08418 Pol_alpha_B_N, 1 hit
PIRSFiPIRSF018300 DNA_pol_alph_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2I4B1U8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALSNAQSLK KELEVFGFPC DDEIIDKMME QCICRGLQAT EMADEWVAYS
60 70 80 90 100
NTKNISNLTL DTLEQFEHEV LLKKNKSKLN SRRDDTYNRP LDINSIQTLI
110 120 130 140 150
NEEIEEETLL DSYSTPAKGS QKRALSTPEH PQPKRSVALL SSPNLLLSPT
160 170 180 190 200
SFSPGATPSQ KYSQRGGKGE VVATFGAVQG TRWVGRKDPG AGVQVELLGP
210 220 230 240 250
PEESLRCSYK FMFQRLRDVR NVLTEKIEDL GQILKSHFTI EEFSSASLPA
260 270 280 290 300
QDSITVLGQI CCDSNGKLNP QSVVLEAEVE HGGQQVPVDL SELKEYSLFP
310 320 330 340 350
GQVVVMEGLN ATGRKFVASK LYEGVPLPFH TPDVTLEADE EPLNVLVACG
360 370 380 390 400
PYTPSDSLNF DPLLDLISVI VRDRPDVCLL LGPFVDSKHE KIEKAQVTET
410 420 430 440 450
FETIFLRCID SIVDGTKSVG CHLVFVPSQR DIHHNFIYPQ PPFTLPNLSK
460 470 480 490 500
DQVQRVTLVS DPCSLLIDGV TVGLTSTDIL FHMGAEEISC GTSSDRFSRI
510 520 530 540 550
LKHILTQRSY YPLYPPAEEL NMDYEKFQRF GQMSFTPDVL IVPSELRYFV
560 570 580 590 600
KDVVGCVCLN PGRLTKGQVG GTFGRLLIRR GAASGDGQRA SPCLAAQVVK

I
Length:601
Mass (Da):66,535
Last modified:February 28, 2018 - v1
Checksum:iDA4D5C020323C809
GO

Sequence databases

RefSeqiXP_013861716.1, XM_014006262.1

Genome annotation databases

GeneIDi106516076

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_013861716.1, XM_014006262.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi106516076

Organism-specific databases

CTDi23649

Family and domain databases

InterProiView protein in InterPro
IPR007185 DNA_pol_alpha/epsilon_bsu
IPR016722 DNA_pol_alpha_bsu
IPR013627 Pol_alpha_B_N
PANTHERiPTHR23061 PTHR23061, 1 hit
PfamiView protein in Pfam
PF04042 DNA_pol_E_B, 1 hit
PF08418 Pol_alpha_B_N, 1 hit
PIRSFiPIRSF018300 DNA_pol_alph_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2I4B1U8_9TELE
AccessioniPrimary (citable) accession number: A0A2I4B1U8
Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: May 23, 2018
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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