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Protein
Submitted name:

KRAS isoform 4

Gene

KRAS

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
KRAS isoform 4Imported
Submitted name:
KRAS proto-oncogene, GTPaseImported
Submitted name:
V-Ki-ras2 Kirsten rat sarcoma viral oncogene homologImported
Gene namesi
Name:KRASImported
ORF Names:CK820_G0019038Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 12

Organism-specific databases

VGNCiVGNC:10375 KRAS

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000008150

Structurei

3D structure databases

SMRiA0A2I3T6U4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
KOiK07827
OrthoDBiEOG091G0UAU
TreeFamiTF312796

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A2I3T6U4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET
60 70 80 90 100
CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI
110 120 130 140 150
KRVKDSEDVP MVLVGNKCDL PSRTVDTKQA QDLARSYGIP FIETSAKTRQ
160 170 180
RVEDAFYTLV REIRQYRLKK ISKEEKTPGC VKIKKCIIM
Length:189
Mass (Da):21,656
Last modified:February 28, 2018 - v1
Checksum:i973547B2E11C2C81
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H2Q5M0H2Q5M0_PANTR
KRAS isoform 2
KRAS CK820_G0019038
188Annotation score:
A0A2I3SCV2A0A2I3SCV2_PANTR
KRAS isoform 3
KRAS CK820_G0019038
43Annotation score:
A0A2I3SWK9A0A2I3SWK9_PANTR
KRAS isoform 1
KRAS CK820_G0019038
75Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04032287 Genomic DNA No translation available.
GABC01006874 mRNA Translation: JAA04464.1
GABF01000567 mRNA Translation: JAA21578.1
GABD01005263 mRNA Translation: JAA27837.1
GABE01004733 mRNA Translation: JAA40006.1
NBAG03000023 Genomic DNA Translation: PNI98728.1
RefSeqiXP_003313842.1, XM_003313794.4
XP_009423991.1, XM_009425716.2

Genome annotation databases

EnsembliENSPTRT00000101699; ENSPTRP00000084588; ENSPTRG00000004775
GeneIDi473387
KEGGiptr:473387

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04032287 Genomic DNA No translation available.
GABC01006874 mRNA Translation: JAA04464.1
GABF01000567 mRNA Translation: JAA21578.1
GABD01005263 mRNA Translation: JAA27837.1
GABE01004733 mRNA Translation: JAA40006.1
NBAG03000023 Genomic DNA Translation: PNI98728.1
RefSeqiXP_003313842.1, XM_003313794.4
XP_009423991.1, XM_009425716.2

3D structure databases

SMRiA0A2I3T6U4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000008150

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000101699; ENSPTRP00000084588; ENSPTRG00000004775
GeneIDi473387
KEGGiptr:473387

Organism-specific databases

CTDi3845
VGNCiVGNC:10375 KRAS

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
KOiK07827
OrthoDBiEOG091G0UAU
TreeFamiTF312796

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2I3T6U4_PANTR
AccessioniPrimary (citable) accession number: A0A2I3T6U4
Secondary accession number(s): A0A2J8QR25
Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: November 7, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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