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Protein

Phosphatidylinositol 3-kinase catalytic subunit type 3

Gene

PIK3C3

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotationImported, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase catalytic subunit type 3UniRule annotation (EC:2.7.1.137UniRule annotation)
Gene namesi
Name:PIK3C3Imported
ORF Names:CK820_G0019478Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 18

Organism-specific databases

VGNCiVGNC:7328 PIK3C3

Subcellular locationi

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000049400

Structurei

3D structure databases

SMRiA0A2I3SV31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 184C2 PI3K-typeInterPro annotationAdd BLAST150
Domaini283 – 520PIK helicalInterPro annotationAdd BLAST238
Domaini631 – 885PI3K/PI4KInterPro annotationAdd BLAST255

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0906 Eukaryota
COG5032 LUCA
GeneTreeiENSGT00760000119110
KOiK00914
OrthoDBiEOG091G036A
TreeFamiTF102032

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR035892 C2_domain_sf
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR002420 PI3K_C2_dom
IPR008290 PI3K_Vps34
IPR015433 PI_Kinase
IPR001263 PInositide-3_kin_accessory_dom
PANTHERiPTHR10048 PTHR10048, 1 hit
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
PF00792 PI3K_C2, 1 hit
PF00613 PI3Ka, 1 hit
PIRSFiPIRSF000587 PI3K_Vps34, 1 hit
SMARTiView protein in SMART
SM00142 PI3K_C2, 1 hit
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51547 PI3K_C2, 1 hit
PS51545 PIK_HELICAL, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A2I3SV31-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEAEKFHYI YSCDLDINVQ LKIGSLEGKR EQKSYKAVLE DPMLKFSGLY
60 70 80 90 100
QETCSDLYVT CQVFAEGKPL ALPVRTSYKA FSTRWNWNEW LKLPVKYPDL
110 120 130 140 150
PRNAQVALTI WDVYGPGKAV PVGGTTVSLF GKYGMFRQGM HDLKVWPNVE
160 170 180 190 200
ADGSEPTKTP GRTSSTLSED QMSRLAKLTK AHRQGHMVKV DWLDRLTFRE
210 220 230 240 250
IEMINESEKR SSNFMYLMVE FRCVKCDDKE YGIVYYEKDG DESSPILTSF
260 270 280 290 300
ELVKVPDPQM SMENLVESKH HKLARSLRSG PSDHDLKPNA ATRDQLNIIV
310 320 330 340 350
SYPPTKQLTY EEQDLVWKFR YYLTNQEKAL TKFLKCVNWD LPQEAKQALE
360 370 380 390 400
LLGKWKPMDV EDSLELLSSH YTNPTVRRYA VARLRQADDE DLLMYLLQLV
410 420 430 440 450
QALKYENFDD IKNGLEPTKK DSQSSVSENV SNSGINSAEI DSSQIITSPL
460 470 480 490 500
PSVSSPPPAS KTKEVPDGEN LEQDLCTFLI SRACKNSTLA NYLYWYVIVE
510 520 530 540 550
CEDQDTQQRD PKTHEMYLNV MRRFSQALLK GDKSVRVMRS LLAAQQTFVD
560 570 580 590 600
RLVHLMKAVQ RESGNRKKKN ERLQALLGDN EKMNLSDVEL IPLPLEPQVK
610 620 630 640 650
IRGIIPETAT LFKSALMPAQ LFFKTEDGGK YPVIFKHGDD LRQDQLILQI
660 670 680 690 700
ISLMDKLLRK ENLDLKLTPY KVLATSTKHG FMQFIQSVPV AEVLDTEGSI
710 720 730 740 750
QNFFRKYAPS ENGPNGISAE VMDTYVKSCA GYCVITYILG VGDRHLDNLL
760 770 780 790 800
LTKTGKLFHI DFGYILGRDP KPLPPPMKLN KEMVEGMGGT QSEQYQEFRK
810 820 830 840 850
QCYTAFLHLR RYSNLILNLF SLMVDANIPD IALEPDKTVK KVQDKFRLDL
860 870 880
SDEEAVHYMQ SLIDESVHAL FAAVVEQIHK FAQYWRK
Length:887
Mass (Da):101,549
Last modified:February 28, 2018 - v1
Checksum:i1C03D97338E44976
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3TRY9A0A2I3TRY9_PANTR
Phosphatidylinositol 3-kinase catal...
PIK3C3
891Annotation score:
H2R6R5H2R6R5_PANTR
Phosphatidylinositol 3-kinase catal...
PIK3C3 CK820_G0019478
824Annotation score:
A0A2I3T8P4A0A2I3T8P4_PANTR
PIK3C3 isoform 13
PIK3C3 CK820_G0019478
103Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04065333 Genomic DNA No translation available.
GABC01002055 mRNA Translation: JAA09283.1
GABF01008794 mRNA Translation: JAA13351.1
GABD01003324 mRNA Translation: JAA29776.1
GABE01004750 mRNA Translation: JAA39989.1
NBAG03000251 Genomic DNA Translation: PNI60723.1
NBAG03000251 Genomic DNA Translation: PNI60724.1
RefSeqiXP_001142812.1, XM_001142812.4

Genome annotation databases

EnsembliENSPTRT00000101442; ENSPTRP00000080817; ENSPTRG00000009983
GeneIDi455385
KEGGiptr:455385

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04065333 Genomic DNA No translation available.
GABC01002055 mRNA Translation: JAA09283.1
GABF01008794 mRNA Translation: JAA13351.1
GABD01003324 mRNA Translation: JAA29776.1
GABE01004750 mRNA Translation: JAA39989.1
NBAG03000251 Genomic DNA Translation: PNI60723.1
NBAG03000251 Genomic DNA Translation: PNI60724.1
RefSeqiXP_001142812.1, XM_001142812.4

3D structure databases

SMRiA0A2I3SV31
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000049400

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000101442; ENSPTRP00000080817; ENSPTRG00000009983
GeneIDi455385
KEGGiptr:455385

Organism-specific databases

CTDi5289
VGNCiVGNC:7328 PIK3C3

Phylogenomic databases

eggNOGiKOG0906 Eukaryota
COG5032 LUCA
GeneTreeiENSGT00760000119110
KOiK00914
OrthoDBiEOG091G036A
TreeFamiTF102032

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR035892 C2_domain_sf
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR002420 PI3K_C2_dom
IPR008290 PI3K_Vps34
IPR015433 PI_Kinase
IPR001263 PInositide-3_kin_accessory_dom
PANTHERiPTHR10048 PTHR10048, 1 hit
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
PF00792 PI3K_C2, 1 hit
PF00613 PI3Ka, 1 hit
PIRSFiPIRSF000587 PI3K_Vps34, 1 hit
SMARTiView protein in SMART
SM00142 PI3K_C2, 1 hit
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51547 PI3K_C2, 1 hit
PS51545 PIK_HELICAL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2I3SV31_PANTR
AccessioniPrimary (citable) accession number: A0A2I3SV31
Secondary accession number(s): A0A2J8MMG3
Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: October 10, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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