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Protein

Tubulin alpha chain

Gene

TUBA4A

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin alpha chainUniRule annotation
Gene namesi
Name:TUBA4AImported
ORF Names:CK820_G0011051Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 2B

Organism-specific databases

VGNCiVGNC:14166 TUBA4A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonSAAS annotation, MicrotubuleUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.UniRule annotationSAAS annotation

Structurei

3D structure databases

SMRiA0A2I3SU24
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 231TubulinInterPro annotationAdd BLAST198
Domaini233 – 378Tubulin_CInterPro annotationAdd BLAST146

Sequence similaritiesi

Belongs to the tubulin family.UniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119060

Family and domain databases

Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002452 Alpha_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01162 ALPHATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A2I3SU24-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNACWELYC LEHGIQPDGQ MPSDKTIGGG DDSFTTFFCE TGAGKHVPRA
60 70 80 90 100
VFVDLEPTVI DEIRNGPYRQ LFHPEQLITG KEDAANNYAR GHYTIGKEII
110 120 130 140 150
DPVLDRIRKL SDQCTGLQGF LVFHSFGGGT GSGFTSLLME RLSVDYGKKS
160 170 180 190 200
KLEFSIYPAP QVSTAVVEPY NSILTTHTTL EHSDCAFMVD NEAIYDICRR
210 220 230 240 250
NLDIERPTYT NLNRLISQIV SSITASLRFD GALNVDLTEF QTNLVPYPRI
260 270 280 290 300
HFPLATYAPV ISAEKAYHEQ LSVAEITNAC FEPANQMVKC DPRHGKYMAC
310 320 330 340 350
CLLYRGDVVP KDVNAAIAAI KTKRSIQFVD WCPTGFKVGI NYQPPTVVPG
360 370 380 390 400
GDLAKVQRAV CMLSNTTAIA EAWARLDHKF DLMYAKRAFV HWYVGEGMEE
410 420 430
GEFSEAREDM AALEKDYEEV GIDSYEDEDE GEE
Length:433
Mass (Da):48,329
Last modified:February 28, 2018 - v1
Checksum:i0448FC0BE3F4872A
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H2QJG6H2QJG6_PANTR
Tubulin alpha chain
TUBA4A CK820_G0011051
448Annotation score:
A0A2I3TT26A0A2I3TT26_PANTR
Tubulin alpha chain
TUBA4A
398Annotation score:
A0A2I3RRN8A0A2I3RRN8_PANTR
Tubulin alpha chain
TUBA4A
381Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04056567 Genomic DNA No translation available.
NBAG03000230 Genomic DNA Translation: PNI70727.1

Genome annotation databases

EnsembliENSPTRT00000099498; ENSPTRP00000080460; ENSPTRG00000012949

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04056567 Genomic DNA No translation available.
NBAG03000230 Genomic DNA Translation: PNI70727.1

3D structure databases

SMRiA0A2I3SU24
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000099498; ENSPTRP00000080460; ENSPTRG00000012949

Organism-specific databases

VGNCiVGNC:14166 TUBA4A

Phylogenomic databases

GeneTreeiENSGT00760000119060

Family and domain databases

Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002452 Alpha_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01162 ALPHATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2I3SU24_PANTR
AccessioniPrimary (citable) accession number: A0A2I3SU24
Secondary accession number(s): A0A2J8NG33
Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: July 18, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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