Integrin beta 1 binding protein 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• GDP-dissociation inhibitor activity Source: Ensembl
• integrin binding Source: Ensembl
• protein kinase binding Source: Ensembl

GO - Biological processⁱ

• activation of protein kinase B activity Source: Ensembl
• blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: Ensembl
• cell-matrix adhesion Source: Ensembl
• cellular response to fibroblast growth factor stimulus Source: Ensembl
• cellular response to vascular endothelial growth factor stimulus Source: Ensembl
• integrin activation Source: Ensembl
• integrin-mediated signaling pathway Source: UniProtKB-KW
• myoblast migration Source: Ensembl
• negative regulation of cell adhesion involved in substrate-bound cell migration Source: Ensembl
• negative regulation of cell migration involved in sprouting angiogenesis Source: Ensembl
• negative regulation of cell population proliferation Source: Ensembl
• negative regulation of ERK1 and ERK2 cascade Source: Ensembl
• negative regulation of fibroblast migration Source: Ensembl
• negative regulation of focal adhesion assembly Source: Ensembl
• negative regulation of protein binding Source: Ensembl
• negative regulation of protein kinase activity Source: Ensembl
• negative regulation of protein targeting to membrane Source: Ensembl
• negative regulation of substrate adhesion-dependent cell spreading Source: Ensembl
• positive regulation of cell population proliferation Source: Ensembl
• positive regulation of endothelial cell migration Source: Ensembl
• positive regulation of focal adhesion assembly Source: Ensembl
• positive regulation of Notch signaling pathway Source: Ensembl
• positive regulation of protein kinase B signaling Source: Ensembl
• positive regulation of protein targeting to membrane Source: Ensembl
• positive regulation of stress fiber assembly Source: Ensembl
• positive regulation of transcription by RNA polymerase II Source: Ensembl
• protein localization to plasma membrane Source: Ensembl
• receptor clustering Source: Ensembl
• regulation of blood vessel diameter Source: Ensembl
• regulation of cell adhesion mediated by integrin Source: Ensembl
• regulation of GTPase activity Source: Ensembl
• regulation of integrin-mediated signaling pathway Source: Ensembl
• tube formation Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• integrin binding Source: Ensembl
• protein kinase binding Source: Ensembl

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MFRKGKKRHS SSSSQSSEIS TKSKSVDSSL GGLSRSSTVA SLDTDSTKSS 
        60         70         80         90        100
GQSNNNSDTC AEFRIKYVGA IEKLKLSEGK GLEGPLDLIN YIDVAQQDGK 
       110        120        130        140        150
LPFVPPEEEF IMGVSKYGIK VSTSDQYDVL HRHALYLIIR MVCYDDGLGA 
       160        170        180        190        200
GKSLLALKTT DASNEEYSLW VYQCNSLEQA QAICKVLSTA FDSVLTSEKP 

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ