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Protein

Aminopeptidase

Gene

ERAP1

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminopeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
AminopeptidaseUniRule annotation (EC:3.4.11.-UniRule annotation)
Gene namesi
Name:ERAP1Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:3978 ERAP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_501413823733 – 941AminopeptidaseSequence analysisAdd BLAST909

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini264 – 524Peptidase_M1InterPro annotationAdd BLAST261
Domaini597 – 916ERAP1_CInterPro annotationAdd BLAST320

Sequence similaritiesi

Belongs to the peptidase M1 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00760000119082

Family and domain databases

CDDicd09601 M1_APN_2, 1 hit
InterProiView protein in InterPro
IPR033520 ERAP1
IPR024571 ERAP1-like_C_dom
IPR034016 M1_APN-typ
IPR001930 Peptidase_M1
IPR014782 Peptidase_M1_N
PANTHERiPTHR11533 PTHR11533, 1 hit
PTHR11533:SF156 PTHR11533:SF156, 1 hit
PfamiView protein in Pfam
PF11838 ERAP1_C, 1 hit
PF01433 Peptidase_M1, 1 hit
PRINTSiPR00756 ALADIPTASE

Sequencei

Sequence statusi: Complete.

A0A2I3SCP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFLPLKWSL ATMSFLLSSL LALLTVSTPS WCQSTEASPK RSDGTPFPWN
60 70 80 90 100
KIRLPEYVIP VHYDLLIHAN LTTLTFWGTT KVEITASQPT STIILHSHHL
110 120 130 140 150
QISRATLRKG AGERLSEEPL QVLEHPPQEQ IALLAPEPLL VGLPYTVVIH
160 170 180 190 200
YAGNLSETFH GFYKSTYRTK EGELRILAST QFEPTAARMA FPCFDEPAFK
210 220 230 240 250
ASFSIKIRRE PRHLAISNMP LVKSVTVAEG LIEDHFDVTV KMSTYLVAFI
260 270 280 290 300
ISDFESVSKI TKSGVKVSVY AVPDKINQAD YALDAAVTLL EFYEDYFSIP
310 320 330 340 350
YPLPKQDLAA IPDFQSGAME NWGLTTYRES ALLFDAEKSS ASSKLGITMT
360 370 380 390 400
VAHELAHQWF GNLVTMEWWN DLWLNEGFAK FMEFVSVSVT HPELKVGDYF
410 420 430 440 450
FGKCFDAMEV DALNSSHPVS TPVENPAQIR EMFDDVSYDK GACILNMLRE
460 470 480 490 500
YLSADAFKSG IVQYLQKHSY KNTKNEDLWD SMASICPTDG VKGMDGFCSR
510 520 530 540 550
SQHSSSSSHW HQEGLDVKTM MNTWTLQKGF PLITITVRGR NVHMKQEHYM
560 570 580 590 600
KGSDGAPDTG YLWHVPLTFI TSKSDMVHRF LLKTKTDVLI LPEEVEWIKF
610 620 630 640 650
NVGMNGYYIV HYEDDGWDSL TGLLKGTHTA VSSNDRASLI NNAFQLVSIG
660 670 680 690 700
KLSIEKALDL SLYLKHETEI MPMFQGLNEL IPMYKLMEKR DMNEVETQFK
710 720 730 740 750
AFLIRLLRDL IDKQTWTDEG SVSERMLRSQ LLLLACVHNY QPCVQRAEGY
760 770 780 790 800
FRKWKESNGN LSLPVDVTLA VFAVGAQSTE GWDFLYSKYQ FSLSSTEKSQ
810 820 830 840 850
IEFALCRTQN KEKLQWLLDE SFKGDKIKTQ EFPQILTLIG RNAVGYPLAW
860 870 880 890 900
QFLRKNWNKL VQKFELGSSS IAHMVMGTTN QFSTRTRLEE VKGFFSSLKE
910 920 930 940
NGSQLRCVQQ TIETIEENIG WMDKNFDKIR VWLQSEKLER M
Length:941
Mass (Da):107,196
Last modified:February 28, 2018 - v1
Checksum:i52FF8CA4DE3BCC1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04045977 Genomic DNA No translation available.
AACZ04045978 Genomic DNA No translation available.
RefSeqiXP_016809011.1, XM_016953522.1

Genome annotation databases

EnsembliENSPTRT00000086474; ENSPTRP00000074798; ENSPTRG00000017095
GeneIDi471835

Similar proteinsi

Entry informationi

Entry nameiA0A2I3SCP2_PANTR
AccessioniPrimary (citable) accession number: A0A2I3SCP2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: May 23, 2018
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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