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UniProtKB - A0A2I3S516 (A0A2I3S516_PANTR)

Entry version 22 (25 May 2022)
Sequence version 1 (28 Feb 2018)
Previous versions | rss
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Protein
Submitted name:

Microtubule actin crosslinking factor 1

Gene

MACF1

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation
LigandMetal-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Microtubule actin crosslinking factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MACF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPan troglodytes (Chimpanzee)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9598 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002277 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...VGNCi		VGNC:58794, MACF1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projectionARBA annotation, Cytoplasm, CytoskeletonPROSITE-ProRule annotation, MembraneARBA annotation, MicrotubuleARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini78 – 181Calponin-homology (CH)InterPro annotationAdd BLAST104
Domaini194 – 298Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini868 – 925SH3InterPro annotationAdd BLAST58
Domaini5083 – 5118EF-handInterPro annotationAdd BLAST36
Domaini5119 – 5154EF-handInterPro annotationAdd BLAST36
Domaini5159 – 5231GARInterPro annotationAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 47DisorderedSequence analysisAdd BLAST47
Regioni3625 – 3645DisorderedSequence analysisAdd BLAST21
Regioni4993 – 5023DisorderedSequence analysisAdd BLAST31
Regioni5247 – 5430DisorderedSequence analysisAdd BLAST184

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili245 – 265Sequence analysisAdd BLAST21
Coiled coili477 – 497Sequence analysisAdd BLAST21
Coiled coili502 – 529Sequence analysisAdd BLAST28
Coiled coili821 – 841Sequence analysisAdd BLAST21
Coiled coili1046 – 1066Sequence analysisAdd BLAST21
Coiled coili1403 – 1433Sequence analysisAdd BLAST31
Coiled coili1497 – 1517Sequence analysisAdd BLAST21
Coiled coili1522 – 1549Sequence analysisAdd BLAST28
Coiled coili1629 – 1663Sequence analysisAdd BLAST35
Coiled coili1793 – 1823Sequence analysisAdd BLAST31
Coiled coili2187 – 2214Sequence analysisAdd BLAST28
Coiled coili2234 – 2254Sequence analysisAdd BLAST21
Coiled coili2292 – 2312Sequence analysisAdd BLAST21
Coiled coili2397 – 2417Sequence analysisAdd BLAST21
Coiled coili2557 – 2577Sequence analysisAdd BLAST21
Coiled coili2616 – 2636Sequence analysisAdd BLAST21
Coiled coili2657 – 2691Sequence analysisAdd BLAST35
Coiled coili2808 – 2828Sequence analysisAdd BLAST21
Coiled coili2929 – 2970Sequence analysisAdd BLAST42
Coiled coili3133 – 3153Sequence analysisAdd BLAST21
Coiled coili3244 – 3264Sequence analysisAdd BLAST21
Coiled coili3897 – 3917Sequence analysisAdd BLAST21
Coiled coili4133 – 4160Sequence analysisAdd BLAST28
Coiled coili4912 – 4932Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8 – 28Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi3629 – 3644Polar residuesSequence analysisAdd BLAST16
Compositional biasi5266 – 5345Polar residuesSequence analysisAdd BLAST80
Compositional biasi5377 – 5430Polar residuesSequence analysisAdd BLAST54

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155824

Identification of Orthologs from Complete Genome Data

More...OMAi		NYYQDSC

Family and domain databases

Conserved Domains Database

More...CDDi		cd00014, CH, 2 hits
cd00051, EFh, 1 hit
cd00176, SPEC, 15 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.418.10, 2 hits
3.30.920.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

The PANTHER Classification System

More...PANTHERi		PTHR23169, PTHR23169, 8 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 18 hits
PF18373, Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00150, SPEC, 33 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

A0A2I3S516-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSDEETLS ERSCRSERSC RSERSYRSER SGSLSPCPPG DTLPWNLPLH 
        60         70         80         90        100
EQKKRKSQDS VLDPAERAVV RVADERDRVQ KKTFTKWVNK HLMKVRKHIN 
       110        120        130        140        150
DLYEDLRDGH NLISLLEVLS GIKLPREKGR MRFHRLQNVQ IALDFLKQRQ 
       160        170        180        190        200
VKLVNIRNDD ITDGNPKLTL GLIWTIILHF QISDIYISGE SGDMSAKEKL 
       210        220        230        240        250
LLWTQKVTAG YTGIKCTNFS SCWSDGKMFN ALIHRYRPDL VDMERVQIQS 
       260        270        280        290        300
NRENLEQAFE VAERLGVTRL LDAEDVDVPS PDEKSVITYV SSIYDAFPKV 
       310        320        330        340        350
PEGGEGISAT EVDSRWQEYQ SRVDSLIPWI KQHTILMSDK TFPQNPVELK 
       360        370        380        390        400
ALYNQYIHFK ETEILAKERE KGRIEELYKL LEVWIEFGRI KLPQGYHPND 
       410        420        430        440        450
VEEEWGKLII EMLEREKSLR PAVERLELLL QIANKIQNGA LNCEEKLTLA 
       460        470        480        490        500
KNTLQADAAH LESGQPVQCE SDVIMYIQEC EGLIRQLQVD LQILRDENYY 
       510        520        530        540        550
QLEELAFRVM RLQDELVTLR LECTNLYRKG HFTSLELVPP CTLTTTHLKA 
       560        570        580        590        600
EPLTKATHSS STSWFRKPMT RAELVAISSS EDEGNLRFVY ELLSWVEEMQ 
       610        620        630        640        650
MKLERAEWGN DLPSVELQLE TQQHIHTSVE ELGSSVKEAR LYEGKMSQNF 
       660        670        680        690        700
HTSYAETLGK LETQYCKLKE TSSFRMRHLQ SLHKFVSRAT AELIWLNEKE 
       710        720        730        740        750
EEELAYDWSD NNSNISAKRN YFSELTMELE EKQDVFRSLQ DTAELLSLEN 
       760        770        780        790        800
HPAKQTVEAY SAAVQSQLQW MKQLCLCVEQ HVKENTAYFQ FFSDARELES 
       810        820        830        840        850
FLRNLQDSIK RKYSCDHNTS LSRLEDLLQD SMDEKEQLIQ SKSSVASLVG 
       860        870        880        890        900
RSKTIVQLKP RSPDHVLKNT ISVKAVCDYR QIEITICKND ECVLEDNSQR 
       910        920        930        940        950
TKWKVISPTG NEAMVPSVCF LIPPPNKDAI EMASRVEQSY QKVMALWHQL 
       960        970        980        990       1000
HVNTKSLISW NYLRKDLDLV QTWNLEKLRS SAPGECHQIM KNLQAHSEDF 
      1010       1020       1030       1040       1050
LQDSRDSVLF SVADRLRLEE EVEACKARFQ HLMKSMENED KEETVAKMYI 
      1060       1070       1080       1090       1100
SELKNIRLRL EEYEQRVVKR IQSLASSRTD RDARQDNALR IAEQEHTQED 
      1110       1120       1130       1140       1150
LQQLRSDLDA VSMKCDSFLH QSPSSSSVPA LRSELNLLVE KMDHVYGLST 
      1160       1170       1180       1190       1200
VYLNKLKTVD VIVRSIQDAE LLVKGYEIKL SQEEVVLADL SALEAHWSTL 
      1210       1220       1230       1240       1250
RHWLSDVKDK NSVFSVLDEE IAKAKAVAEQ MSRLTPERNL DLERYQEKGS 
      1260       1270       1280       1290       1300
QLQERWHRVI AQLEIRQSEL ESIQEVLGDY RACHGTLIKW IEETTAQQEM 
      1310       1320       1330       1340       1350
MKPGQAEDSR VLSEQLSQQT ALFAEIERNQ TKLDQCQKFS QQYSTIVKDY 
      1360       1370       1380       1390       1400
ELQLMTYKAF VESQQKSPGK RRRMLSSSDA ITQEFMDLRT RYTALVTLTT 
      1410       1420       1430       1440       1450
QHVKYISDAL RRLEEEEKVV EEEKQEHVEK VKELLGWVST LARNTQGKAT 
      1460       1470       1480       1490       1500
SSETKESTDI EKAILEQQVL SEELTTKKEQ VSEAIKTSQI FLAKHGHKLS 
      1510       1520       1530       1540       1550
EKEKKQISEQ LNALNKAYHD LCDGSANQLQ QLQSQLAHQT EQKTLQKQQN 
      1560       1570       1580       1590       1600
TCHQQLEDLC SWVGQAERAL AGHQGRTTQR DLSALQKNQS DLKDLQDDIQ 
      1610       1620       1630       1640       1650
NRATSFATVV KDIEGFMEEN QTKLSPRELT ALREKLHQAK EQYEALQEET 
      1660       1670       1680       1690       1700
RVAQKELEEA VTSALQQETE KSKAAKELAE NKKKIDALLD WVTSVGSSGG 
      1710       1720       1730       1740       1750
QLLTNLPGME QLSGASLEKG ALDTTDGYMG VNQAPEKLDK QCEMMKARHQ 
      1760       1770       1780       1790       1800
ELLSQQQNFI LATQSAQAFL DQHGHNLTPE EQQMLQQKLG ELKEQYSTSL 
      1810       1820       1830       1840       1850
AQSEAELKQV QTLQDELQKF LQDHREFESW LERSEKELEN MHKGGSSPEA 
      1860       1870       1880       1890       1900
LPSLLKRQGS FSEDVISHKG DLRFVTISGQ KVLDMENSFK EGKEPSEIGN 
      1910       1920       1930       1940       1950
LVKDKLKDAT ERYTALHSKC TRLGSHLNML LGQYHQFQNS ADSLQAWMQA 
      1960       1970       1980       1990       2000
CEANVEKLLS DTVASDPGVL QEQLATTKQL QEELAEHQVP VEKLQKVARD 
      2010       2020       2030       2040       2050
IMEIEGEPAP DHRHVQETTD SILSHFQSLS YSLAERSSLL QKAIAQSQSV 
      2060       2070       2080       2090       2100
QESLESLLQS IGEVEQNLEG KQVSSLSSGV IQEALATNMK LKQDIARQKS 
      2110       2120       2130       2140       2150
SLEATREMVT RFMETADSTT AAVLQGKLAE VSQRFEQLCL QQQEKESSLK 
      2160       2170       2180       2190       2200
KLLPQAEMFE HLSGKLQQFM ENKSRMLASG NQPDQDITHF FQQIQELNLE 
      2210       2220       2230       2240       2250
MEDQQENLDT LEHLVTELSS CGFALDLCQH QDRVQNLRKD FTELQKTVKE 
      2260       2270       2280       2290       2300
REKDASSCQE QLDEFRKLVR TFQKWLKETE GSIPPTETST SAKELEKQIE 
      2310       2320       2330       2340       2350
HLKSLLDDWA SKGTLVEEIN CKGTSLENLI MEITAPDSQG KTGSILPSVG 
      2360       2370       2380       2390       2400
SSVGSVNGYH TCKDLTEIQC DMSDVNLKYE KLGGVLHERQ ESLQAILNRM 
      2410       2420       2430       2440       2450
EEVHKEANSV LQWLESKEEV LKSMDAMSSP TKTETVKAQA ESNKAFLAEL 
      2460       2470       2480       2490       2500
EQNSPKIQKV KEALAGLLVT YPNSQEAENW KKIQEELNSR WERATEVTVA 
      2510       2520       2530       2540       2550
RQRQLEESAS HLACFQAAES QLRPWLMEKE LMMGVLGPLS IDPNMLNAQK 
      2560       2570       2580       2590       2600
QQVQFMLKEF EARRQQHEQL NEAAQGILTG PGDVSLSTSQ VQKELQSINQ 
      2610       2620       2630       2640       2650
KWVELTDKLN SRSSQIDQAI VKSTQYQELL QDLSEKVRAV GQRLSVQSAI 
      2660       2670       2680       2690       2700
STQPEAVKQQ LEETSEIRSD LEQLDHEVKE AQTLCDELSV LIGEQYLKDE 
      2710       2720       2730       2740       2750
LKKRLETVAL PLQGLEDLAA DRMNRLQAAL ASTQQFQQMF DELRTWLDDK 
      2760       2770       2780       2790       2800
QSQQAKNCPI SAKLERLQSQ LQENEEFQKS LNQHSGSYEV IVAEGESLLL 
      2810       2820       2830       2840       2850
SVPPGEEKRT LQNQLVELKN HWEELSKKTA DRQSRLKDCM QKAQKYQWHV 
      2860       2870       2880       2890       2900
EDLVPWIEDC KAKMSELRVT LDPVQLESSL LRSKAMLSEV EKRRSLLEIL 
      2910       2920       2930       2940       2950
NSAADILINS SEADEDGIRD EKAGINQNMD AVTEELQAKT GSLEEMTQRL 
      2960       2970       2980       2990       3000
KEFQESFKNI EKKVEGAKHQ LEIFDALGSQ ACSNKNLEKL RAQQEVLQAL 
      3010       3020       3030       3040       3050
EPQVDYLRNF TQGLVEDAPD GSDASQLLHQ AEVAQQEFLE VKQRVNSGCV 
      3060       3070       3080       3090       3100
MMENKLEGIG QFHCRVREMF SQLADLDDEL DGMGAIGRDT DSLQSQIEDV 
      3110       3120       3130       3140       3150
RLFLNKIHIL KLDIEASEAE CRHMLEEEGT LDLLGLKREL EALNKQCGKL 
      3160       3170       3180       3190       3200
TERGKARQEQ LELTLGRVED FYRKLKGLND ATTAAEEAEA LQWVVGTEVE 
      3210       3220       3230       3240       3250
IINQQLADFK MFQKEQVDPL QMKLQQVNGL GQGLIQSAGK DCDVQGLEHD 
      3260       3270       3280       3290       3300
MEEINARWNT LNKKVAQRIA QLQEALLHCG KFQDALEPLL SWLADTEELI 
      3310       3320       3330       3340       3350
ANQKPPSAEY KVVKAQIQEQ KLLQRLLDDR KATVDMLQAE GGRIAQSAEL 
      3360       3370       3380       3390       3400
ADREKITGQL ESLESRWTEL LSKAAARQKQ LEDILVLAKQ FHETAEPISD 
      3410       3420       3430       3440       3450
FLSVTEKKLA NSEPVGTQTA KIQQQIIRHK ALEEDIENHA TDVHQAVKIG 
      3460       3470       3480       3490       3500
QSLSSLTSPA EQGVLSEKID SLQARYSEIQ DRCCRKAALL DQALSNARLF 
      3510       3520       3530       3540       3550
GEDEVEVLNW LAEVEDKLSS VFVKDFKQDV LHRQHADHLA LNEEIVNRKK 
      3560       3570       3580       3590       3600
NVDQAIKNGQ ALLKQTTGEE VLLIQEKLDG IKTRYADITV TSSKALRTLE 
      3610       3620       3630       3640       3650
QARQLATKFQ STYEELTGWL REVEEELATS GGQSPTGEQI PQFQQRQKEL 
      3660       3670       3680       3690       3700
KKEVMEHRLV LDTVNEVSRA LLELVPWRAR EGLDKLVSDA NEQYKLVSDT 
      3710       3720       3730       3740       3750
IGQRVDEIDA AIQRSQQYEQ AADAELAWVA ETKRKLMALG PIRLEQDQTT 
      3760       3770       3780       3790       3800
AQLQVQKAFS IDIIRHKDSM DELFSHRSEI FGTCGEEQKT VLQEKTESLI 
      3810       3820       3830       3840       3850
QQYEAISLLN SERYARLERA QVLVNQFWET YEELSPWIEE TRALIAQLPP 
      3860       3870       3880       3890       3900
PAIDHEQLRQ QQEEMRQLRE SIAEHKPHID KLLKIGPQLK ELNTEEGEMV 
      3910       3920       3930       3940       3950
EEKYQKAENM YAQIKEEVRQ RALALDEAVS QSTQITEFHD KIEPMLETLE 
      3960       3970       3980       3990       4000
NLSSRLRMPP LIPAEVDKIR ECISDNKSAT VELEKLQPSF EALKRRGEEL 
      4010       4020       4030       4040       4050
IGRSQGADKD LAAKEIQDKL DQMVFFWEDI KARAEEREIK FLDVLELAEK 
      4060       4070       4080       4090       4100
FWYDMAALLT TIKDTQDIVH DLESPGIDPS IIKQQVEAAE TIKEETDGLH 
      4110       4120       4130       4140       4150
EELEFIRILG ADLIFACGET EKPEVRKSID EMNNAWENLN KTWKERLEKL 
      4160       4170       4180       4190       4200
EDAMQAAVQY QDTLQAMFDW LDNTVIKLCT MPPVGTDLNT VKDQLNEMKE 
      4210       4220       4230       4240       4250
FKVEVYQQQI EMEKLNHQGE LMLKKATDET DRDIIREPLT ELKHLWENLG 
      4260       4270       4280       4290       4300
EKIAHRQHKL EGALLALGQF QHALEELMSW LTHTEELLDA QRPISGDPKV 
      4310       4320       4330       4340       4350
IEVELAKHHV LKNDVLAHQA TVETVNKAGN ELLESSAGDD ASSLRSRLET 
      4360       4370       4380       4390       4400
MNQCWESVLQ KTEEREQQLQ STLQQAQGFH SEIEDFLLEL TRMESQLSAS 
      4410       4420       4430       4440       4450
KPTGGLPETA REQLDTHMEL YSQLKAKEET YNQLLDKGRL MLLSRDDSGS 
      4460       4470       4480       4490       4500
GSKTEQSVAL LEQKWHVVSS KMEERKSKLE EALNLATEFQ NSLQEFINWL 
      4510       4520       4530       4540       4550
TLAEQSLNIA SPPSLILNTV LSQIEEHKVF ANEVNAHRDQ IIELDQTGNQ 
      4560       4570       4580       4590       4600
LKFLSQKQDV VLIKNLLVSV QSRWEKVVQR SIERGRSLDD ARKRAKQFHE 
      4610       4620       4630       4640       4650
AWKKLIDWLE DAESHLDSEL EISNDPDKIK LQLSKHKEFQ KTLGGKQPVY 
      4660       4670       4680       4690       4700
DTTIRTGRAL KEKTLLPEDT QKLDNFLGEV RDKWDTVCGK SVERQHKLEE 
      4710       4720       4730       4740       4750
ALLFSGQFMD ALQALVDWLY KVEPQLAEDQ PVHGDLDLVM NLMDAHKVFQ 
      4760       4770       4780       4790       4800
KELGKRTGTV QVLKRSGREL IENSRDDTTW VKGQLQELST RWDTVCKLSV 
      4810       4820       4830       4840       4850
SKQSRLEQAL KQAEVFRDTV HMLLEWLSEA EQTLRFRGAL PDDTEALQSL 
      4860       4870       4880       4890       4900
IDTHKEFMKK VEEKRVDVNS AVAMGEVILA VCHPDCITTI KHWITIIRAR 
      4910       4920       4930       4940       4950
FEEVLTWAKQ HQQRLETALS ELVANAELLE ELLAWIQWAE TTLIQRDQEP 
      4960       4970       4980       4990       5000
IPQNIDRVKA LIAEHQTFME EMTRKQPDVD RVTKTYKRKN IEPTHAPFIE 
      5010       5020       5030       5040       5050
KSRSGGRKSL SQPTPPPMPI LSQSEAKNPR INQLSARWQQ VWLLALERQR 
      5060       5070       5080       5090       5100
KLNDALDRLE ELKEFANFDF DVWRKKYMRW MNHKKSRVMD FFRRIDKDQD 
      5110       5120       5130       5140       5150
GKITRQEFID GILASKFPTT KLEMTAVADI FDRDGDGYID YYEFVAALHP 
      5160       5170       5180       5190       5200
NKDAYRPTTD ADKIEDEVTR QVAQCKCAKR FQVEQIGENK YRFGDSQQLR 
      5210       5220       5230       5240       5250
LVRILRSTVM VRVGGGWMAL DEFLVKNDPC RARGRTNIEL REKFILPEGA 
      5260       5270       5280       5290       5300
SQGMTPFRSR GRRSKPSSRA ASPTRSSSSA SQSNHSCTSM PSSPATPASG 
      5310       5320       5330       5340       5350
TKVIPSSGSK LKRPTPTFHS SRTSLAGDTS NSSSPASTGA KTNRADPKKS 
      5360       5370       5380       5390       5400
ASRPGSRAGS RAGSRASSRR GSDASDFDLL ETQSACSDTS ESSAAGGQGN 
      5410       5420       5430
SRRGLNKPSK IPTMSKKTTT ASPRTPGPKR
Length:5,430
Mass (Da):620,301
Last modified:February 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFA9384C932540D5A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3RDN9A0A2I3RDN9_PANTR
Microtubule actin crosslinking fact...
MACF1
7,594Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3TWP1A0A2I3TWP1_PANTR
Microtubule actin crosslinking fact...
MACF1
7,390Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3S6Z9A0A2I3S6Z9_PANTR
Microtubule actin crosslinking fact...
MACF1
7,557Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3T4F2A0A2I3T4F2_PANTR
Microtubule actin crosslinking fact...
MACF1
7,567Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3SUW3A0A2I3SUW3_PANTR
Microtubule actin crosslinking fact...
MACF1
1,061Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3SNF2A0A2I3SNF2_PANTR
Microtubule actin crosslinking fact...
MACF1
616Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2J8LYL0A0A2J8LYL0_PANTR
Microtubule actin crosslinking fact...
MACF1
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AACZ04072142 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_009452665.1, XM_009454390.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSPTRT00000099293; ENSPTRP00000072118; ENSPTRG00000043118

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04072142 Genomic DNA No translation available.
RefSeqiXP_009452665.1, XM_009454390.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSPTRT00000099293; ENSPTRP00000072118; ENSPTRG00000043118

Organism-specific databases

VGNCiVGNC:58794, MACF1

Phylogenomic databases

GeneTreeiENSGT00940000155824
OMAiNYYQDSC

Family and domain databases

CDDicd00014, CH, 2 hits
cd00051, EFh, 1 hit
cd00176, SPEC, 15 hits
Gene3Di1.10.418.10, 2 hits
3.30.920.20, 1 hit
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PANTHERiPTHR23169, PTHR23169, 8 hits
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 18 hits
PF18373, Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00150, SPEC, 33 hits
SUPFAMiSSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2I3S516_PANTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2I3S516
Secondary accession number(s): A0A2J8LYN7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: May 25, 2022
This is version 22 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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