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Protein
Submitted name:

Neuregulin 3

Gene

NRG3

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Neuregulin 3Imported
Gene namesi
Name:NRG3Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 10

Organism-specific databases

VGNCiVGNC:12409 NRG3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei67 – 91HelicalSequence analysisAdd BLAST25
Transmembranei362 – 384HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi320 ↔ 329PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini287 – 330EGF-likeInterPro annotationAdd BLAST44

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00900000140940

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR002154 Neuregulin_C
PfamiView protein in Pfam
PF02158 Neuregulin, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A2I3S2M2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEGAAAASP PGAASAAAAS AEEGTAAAAA AAAAAGGGPD GGGEGAAEPP
60 70 80 90 100
RELRCSDCIV WNRQQTWLCV VPLFIGFIGL GLSLMLLKWI VVGSVKEYVP
110 120 130 140 150
TDLVDSKGMG QDPFFLSKPS SFPKAMETTT TTTSTTSPAT PSAGGAASSR
160 170 180 190 200
TPNRISTRLT TITRAPTRFP GHRVPIRASP RSTTARNTAA PATVPSTTAP
210 220 230 240 250
FFSSSTPGSR PPVPGTPSTQ AMPSWPTAAY ATSSYLHDST PSWTLSPFQD
260 270 280 290 300
AASSSSSSSS SATTTTPETS TSPKFHTTTY STERSEHFKP CRDKDLAYCL
310 320 330 340 350
NDGECFVIET LTGSHKHCRC KEGYQGVRCD QFLPKTDSIL SDPTDHLGIE
360 370 380 390 400
FMESEEVYQR QVLSISCIIF GIVIVGMFCA AFYFKSKKQA KQIQEQLKVP
410 420 430 440 450
QNGKSYSLKA SSTMAKSENL VKSHVQLQNY SKVERHPVTA LEKMMESSFV
460 470 480 490 500
GPQSFPEVPS PDRGSQSVKH HRSLSSCCSP GQRSGMLHRN AFRRTPPSPR
510 520 530 540 550
SRLGGIVGPA YQQLEESRIP DQDTIPCQGI EVRKTISHLP IQLWCVERPL
560 570 580 590 600
DLKYSSNGLK TQRNTSINMQ LPSRETNPYF NSLEQKDLVG YSSTRASSVP
610 620 630 640 650
IIPSVGLEET CLQMPGISEV KSIKWCKNSY SADVVNVSIP VSDCLIAEQQ
660 670 680 690 700
EVKILLETVQ EQIRILTDAR RSEDYELASV ETEDSASENT AFLPLSPTAK
710 720
SEREAQFVLR NEIQRDSALT K
Length:721
Mass (Da):77,983
Last modified:February 28, 2018 - v1
Checksum:iF9C87791DBEC5ADE
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H2RE16H2RE16_PANTR
Neuregulin 3
NRG3
500Annotation score:
A0A2I3TDF7A0A2I3TDF7_PANTR
Neuregulin 3
NRG3
697Annotation score:
A0A2I3RRX6A0A2I3RRX6_PANTR
Neuregulin 3
NRG3
526Annotation score:
A0A2I3TI56A0A2I3TI56_PANTR
Neuregulin 3
NRG3
348Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04042503 Genomic DNA No translation available.
AACZ04042504 Genomic DNA No translation available.
AACZ04042505 Genomic DNA No translation available.
AACZ04042506 Genomic DNA No translation available.
AACZ04042507 Genomic DNA No translation available.
AACZ04042508 Genomic DNA No translation available.
AACZ04042509 Genomic DNA No translation available.
AACZ04042510 Genomic DNA No translation available.
AACZ04042511 Genomic DNA No translation available.
RefSeqiXP_016774255.1, XM_016918766.1

Genome annotation databases

EnsembliENSPTRT00000087338; ENSPTRP00000071183; ENSPTRG00000002689
GeneIDi466296

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04042503 Genomic DNA No translation available.
AACZ04042504 Genomic DNA No translation available.
AACZ04042505 Genomic DNA No translation available.
AACZ04042506 Genomic DNA No translation available.
AACZ04042507 Genomic DNA No translation available.
AACZ04042508 Genomic DNA No translation available.
AACZ04042509 Genomic DNA No translation available.
AACZ04042510 Genomic DNA No translation available.
AACZ04042511 Genomic DNA No translation available.
RefSeqiXP_016774255.1, XM_016918766.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000087338; ENSPTRP00000071183; ENSPTRG00000002689
GeneIDi466296

Organism-specific databases

CTDi10718
VGNCiVGNC:12409 NRG3

Phylogenomic databases

GeneTreeiENSGT00900000140940

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR002154 Neuregulin_C
PfamiView protein in Pfam
PF02158 Neuregulin, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2I3S2M2_PANTR
AccessioniPrimary (citable) accession number: A0A2I3S2M2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: September 12, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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