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Entry version 8 (05 Jun 2019)
Sequence version 1 (28 Feb 2018)
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Protein
Submitted name:

TJP2 isoform 11

Gene

TJP2

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TJP2 isoform 11Imported
Submitted name:
Tight junction protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TJP2Imported
ORF Names:CK820_G0017728Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPan troglodytes (Chimpanzee)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9598 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002277 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:4877 TJP2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 124PDZInterPro annotationAdd BLAST88
Domaini311 – 389PDZInterPro annotationAdd BLAST79
Domaini513 – 594PDZInterPro annotationAdd BLAST82
Domaini608 – 673SH3InterPro annotationAdd BLAST66
Domaini694 – 880Guanylate kinase-likeInterPro annotationAdd BLAST187

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni156 – 311DisorderedSequence analysisAdd BLAST156
Regioni412 – 510DisorderedSequence analysisAdd BLAST99
Regioni924 – 1049DisorderedSequence analysisAdd BLAST126
Regioni1072 – 1157DisorderedSequence analysisAdd BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi166 – 300PolyampholyteSequence analysisAdd BLAST135
Compositional biasi412 – 449PolyampholyteSequence analysisAdd BLAST38
Compositional biasi931 – 945AcidicSequence analysisAdd BLAST15
Compositional biasi959 – 978PolyampholyteSequence analysisAdd BLAST20
Compositional biasi979 – 994PolarSequence analysisAdd BLAST16
Compositional biasi1092 – 1113Pro-richSequence analysisAdd BLAST22
Compositional biasi1124 – 1139PolyampholyteSequence analysisAdd BLAST16

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MAGUK family.SAAS annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158634

Database of Orthologous Groups

More...
OrthoDBi
1175136at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12027 SH3_ZO-2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR005417 ZO
IPR005419 ZO-2
IPR035598 ZO-2_SH3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 3 hits
PF07653 SH3_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01597 ZONOCCLUDNS
PR01599 ZONOCCLUDNS2

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 3 hits
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 3 hits
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

A0A2I3RS14-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTAQALHRM WIQAVKKLRR WKGHAPGMEE LIWEQYTVTL QKDSKRGFGI
60 70 80 90 100
AVSGGRDNPH FENGETSIVI SDVLPGGPAD GLLQENDRVV MVNGTPMEDV
110 120 130 140 150
LHSFAVQQLR KSGKVAAIVV KRPRKVQVAP LQASPPLDQD DRAFEVMDEF
160 170 180 190 200
DGRSFRSGYS ERSRLSSHGG RSRSWEDSPE RGRPHERARS RERDLSRDRS
210 220 230 240 250
RGRSLERGLD QDHARTRDRS RGRSLERGLD HDFGPSRDRD RDRSRGRSID
260 270 280 290 300
QDYERAYHQA YDPDYERAYS PEYRRGARHD ARSRGPRSRS REHPHSRSPS
310 320 330 340 350
PEPRGRPGPI GVLLMKSRAN EEYGLRLGSQ IFVKEMTRTG LATKDGNLHE
360 370 380 390 400
GDIILKINGT VTENMSLTDA RKLIEKSRGK LQLVVLRDSQ QTLINIPSLN
410 420 430 440 450
DSDSEIEDIS EIESNRSFSP EERRHQYSDY DYHSSSEKLK ERPSSREDTP
460 470 480 490 500
SRLSRMGATP TPFKSTGDIA GTVVPETNKE PRYQEDPPAP QPKAAPRTFL
510 520 530 540 550
RPSPEDEAIY GPNTKMVRFK KGDSVGLRLA GGNDVGIFVA GIQEGTSAEQ
560 570 580 590 600
EGLQEGDQIL KVNTQDFRGL VREDAVLYLL EIPKGEMVTI LAQSRADVYR
610 620 630 640 650
DILACGRGDS FFIRSHFECE KETPQSLAFT RGEVFRVVDT LYDGKLGNWL
660 670 680 690 700
AVRIGNELEK GLIPNKSRAE QMASVQNAQR DNAGDRADFW RMRGQRSGVK
710 720 730 740 750
KNLRKSREDL TAVVSVSTKF PAYERVLLRE AGFKRPVVLF GPIADIAMEK
760 770 780 790 800
LANELPDWFQ TAKTEPKDAG SEKSTGVVRL NTVRQIIEQD KHALLDVTPK
810 820 830 840 850
AVDLLNYTQW FPIVIFFNPD SRQGVKTMRQ RLNPTSNKSS RKLFDQANKL
860 870 880 890 900
KKTCAHLFTA TINLNSANDS WFGSLKDTIQ HQQGEAVWVS EGKMEGMDDD
910 920 930 940 950
PEDRMSYLTA MGADYLSCDS RLISDFEDTD GEGGAYTDNE LDEPAEEPLV
960 970 980 990 1000
SSITRSSEPV QHEEAKTQNK EESYDFSKSY EYKSNPSAVA GNETPGASTK
1010 1020 1030 1040 1050
GYPPPVAAKP TFGRSILKPS TPIPPQEGEE VGESSEEQDN APKSVLGKVK
1060 1070 1080 1090 1100
IFEKMDHKAR LQRMQELQEA QNARIEIAQR HPDIYAVPIK THKPDPGPPQ
1110 1120 1130 1140 1150
HTSSRPPEPQ KAPSRPYQDT RGSYGSDAEE EEYRQQLSEH SKRGYYGQSA

RYRDTEL
Length:1,157
Mass (Da):130,422
Last modified:February 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB787312801C8D309
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H2QXC0H2QXC0_PANTR
Tight junction protein 2
TJP2
1,194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3RUH6A0A2I3RUH6_PANTR
TJP2 isoform 8
TJP2 CK820_G0017728
1,043Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3SY75A0A2I3SY75_PANTR
TJP2 isoform 7
TJP2 CK820_G0017728
1,190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3RZN4A0A2I3RZN4_PANTR
Tight junction protein 2
TJP2
1,167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3RIL3A0A2I3RIL3_PANTR
TJP2 isoform 4
TJP2 CK820_G0017728
1,249Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3S7U2A0A2I3S7U2_PANTR
Tight junction protein 2
TJP2
1,213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AACZ04029799 Genomic DNA No translation available.
NBAG03000246 Genomic DNA Translation: PNI62002.1

NCBI Reference Sequences

More...
RefSeqi
XP_003312177.2, XM_003312129.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSPTRT00000088806; ENSPTRP00000067475; ENSPTRG00000021005

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
464514

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04029799 Genomic DNA No translation available.
NBAG03000246 Genomic DNA Translation: PNI62002.1
RefSeqiXP_003312177.2, XM_003312129.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000088806; ENSPTRP00000067475; ENSPTRG00000021005
GeneIDi464514

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9414
VGNCiVGNC:4877 TJP2

Phylogenomic databases

GeneTreeiENSGT00940000158634
OrthoDBi1175136at2759

Family and domain databases

CDDicd12027 SH3_ZO-2, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR005417 ZO
IPR005419 ZO-2
IPR035598 ZO-2_SH3
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 3 hits
PF07653 SH3_2, 1 hit
PRINTSiPR01597 ZONOCCLUDNS
PR01599 ZONOCCLUDNS2
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 3 hits
SUPFAMiSSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 3 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 3 hits
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2I3RS14_PANTR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2I3RS14
Secondary accession number(s): A0A2J8MR62
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: June 5, 2019
This is version 8 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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