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Protein

Methionine aminopeptidase

Gene

METAP1D

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Co2+UniRule annotation, Zn2+UniRule annotation, Mn2+UniRule annotation, Fe2+UniRule annotationNote: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei43SubstrateUniRule annotation1
Metal bindingi60Divalent metal cation 1UniRule annotation1
Metal bindingi71Divalent metal cation 1UniRule annotation1
Metal bindingi71Divalent metal cation 2; catalyticUniRule annotation1
Metal bindingi134Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation1
Binding sitei141SubstrateUniRule annotation1
Metal bindingi166Divalent metal cation 2; catalyticUniRule annotation1
Metal bindingi197Divalent metal cation 1UniRule annotation1
Metal bindingi197Divalent metal cation 2; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminopeptidaseUniRule annotation, Hydrolase, Protease
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidaseUniRule annotation (EC:3.4.11.18UniRule annotation)
Gene namesi
Name:METAP1DImported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 2B

Organism-specific databases

VGNCiVGNC:14332 METAP1D

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 203Peptidase_M24InterPro annotationAdd BLAST203

Sequence similaritiesi

Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000002284

Family and domain databases

CDDicd01086 MetAP1, 1 hit
HAMAPiMF_01974 MetAP_1, 1 hit
InterProiView protein in InterPro
IPR036005 Creatinase/aminopeptidase-like
IPR000994 Pept_M24
IPR001714 Pept_M24_MAP
IPR002467 Pept_M24A_MAP1
PfamiView protein in Pfam
PF00557 Peptidase_M24, 1 hit
PRINTSiPR00599 MAPEPTIDASE
SUPFAMiSSF55920 SSF55920, 1 hit
TIGRFAMsiTIGR00500 met_pdase_I, 1 hit
PROSITEiView protein in PROSITE
PS00680 MAP_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A2I3RNF6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTEEIDALV HREIISHNAY PSPLGYGGFP KSVCTSVNNV LCHGIPDSRP
60 70 80 90 100
LQDGDIINID VTVYYNGYHG DTSETFLVGN VDECGKKLVE VARRCRDEAI
110 120 130 140 150
AACRAGAPFS VIGNTISHIT HQNGFQVCPH FVGHGIGSYF HGHPEIWHHA
160 170 180 190 200
NDNDLPMEEG MAFTIEPIIT EGSPEFKVLE DAWTVVSLDN QRSAQFEHTV
210
LITSRGAQIL TKLPHEA
Length:217
Mass (Da):23,860
Last modified:February 28, 2018 - v1
Checksum:iC59026BA1551B9F2
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3SY62A0A2I3SY62_PANTR
Methionine aminopeptidase
METAP1D CK820_G0001478
335Annotation score:
H2QIZ4H2QIZ4_PANTR
Methionine aminopeptidase
METAP1D
327Annotation score:
A0A2I3TC27A0A2I3TC27_PANTR
Methionine aminopeptidase
METAP1D
330Annotation score:
A0A2I3RNL1A0A2I3RNL1_PANTR
Methionyl aminopeptidase type 1D, m...
METAP1D
146Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04058531 Genomic DNA No translation available.
RefSeqiXP_016805526.1, XM_016950037.1
XP_016805527.1, XM_016950038.1

Genome annotation databases

EnsembliENSPTRT00000078376; ENSPTRP00000066236; ENSPTRG00000012638
GeneIDi100609894

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04058531 Genomic DNA No translation available.
RefSeqiXP_016805526.1, XM_016950037.1
XP_016805527.1, XM_016950038.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000078376; ENSPTRP00000066236; ENSPTRG00000012638
GeneIDi100609894

Organism-specific databases

CTDi254042
VGNCiVGNC:14332 METAP1D

Phylogenomic databases

GeneTreeiENSGT00390000002284

Family and domain databases

CDDicd01086 MetAP1, 1 hit
HAMAPiMF_01974 MetAP_1, 1 hit
InterProiView protein in InterPro
IPR036005 Creatinase/aminopeptidase-like
IPR000994 Pept_M24
IPR001714 Pept_M24_MAP
IPR002467 Pept_M24A_MAP1
PfamiView protein in Pfam
PF00557 Peptidase_M24, 1 hit
PRINTSiPR00599 MAPEPTIDASE
SUPFAMiSSF55920 SSF55920, 1 hit
TIGRFAMsiTIGR00500 met_pdase_I, 1 hit
PROSITEiView protein in PROSITE
PS00680 MAP_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2I3RNF6_PANTR
AccessioniPrimary (citable) accession number: A0A2I3RNF6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: May 23, 2018
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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