Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 12 (31 Jul 2019)
Sequence version 1 (28 Feb 2018)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

LsmAD domain-containing protein

Gene

ATXN2

Organism
Papio anubis (Olive baboon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LsmAD domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATXN2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPapio anubis (Olive baboon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9555 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000028761 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei247 – 268HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A2I3LC85 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini413 – 481LsmADInterPro annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 237DisorderedSequence analysisAdd BLAST237
Regioni463 – 958DisorderedSequence analysisAdd BLAST496
Regioni1141 – 1223DisorderedSequence analysisAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi53 – 69Pro-richSequence analysisAdd BLAST17
Compositional biasi162 – 188PolarSequence analysisAdd BLAST27
Compositional biasi204 – 230PolarSequence analysisAdd BLAST27
Compositional biasi463 – 492PolyampholyteSequence analysisAdd BLAST30
Compositional biasi508 – 549PolarSequence analysisAdd BLAST42
Compositional biasi581 – 606Pro-richSequence analysisAdd BLAST26
Compositional biasi664 – 685PolarSequence analysisAdd BLAST22
Compositional biasi694 – 711PolarSequence analysisAdd BLAST18
Compositional biasi735 – 785PolarSequence analysisAdd BLAST51
Compositional biasi788 – 807PolyampholyteSequence analysisAdd BLAST20
Compositional biasi808 – 822PolarSequence analysisAdd BLAST15
Compositional biasi823 – 845PolyampholyteSequence analysisAdd BLAST23
Compositional biasi846 – 895PolarSequence analysisAdd BLAST50
Compositional biasi896 – 913PolyampholyteSequence analysisAdd BLAST18
Compositional biasi914 – 936PolarSequence analysisAdd BLAST23
Compositional biasi1154 – 1199PolarSequence analysisAdd BLAST46
Compositional biasi1207 – 1223PolarSequence analysisAdd BLAST17

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156812

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009818 Ataxin-2_C
IPR033093 ATXN2
IPR010920 LSM_dom_sf
IPR009604 LsmAD_domain
IPR025852 SM_dom_ATX

The PANTHER Classification System

More...
PANTHERi
PTHR12854:SF11 PTHR12854:SF11, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06741 LsmAD, 1 hit
PF07145 PAM2, 1 hit
PF14438 SM-ATX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01272 LsmAD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50182 SSF50182, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A2I3LC85-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSVAAAPRS PAAGTKSRPF AAANWPGWRS LQRPAPRSGR GGGGVASGQY
60 70 80 90 100
PSAAPPPSGP GPPPSRQRSP PSASDCFGCN GNGGGAFRPG SPQLLGLGGP
110 120 130 140 150
PRPFVVLLLP LGSPGPPPAA PTRASPLGAR ASPPRSGVSS ARPAPGCPRP
160 170 180 190 200
ACEPPVYGPL SMSLKPQQQQ QQQQQQQQQQ QQQQPPAAAN VRKPGGSGLL
210 220 230 240 250
ASPAAAPSPS SSSVSSSSAT TPSSAAAATS GGGRSGLGRG RNSNKGLLFF
260 270 280 290 300
FFFFFFLIFQ ISFDGIYANM RMVHILTSVV GSKCEVQVKN GGIYEGVFKT
310 320 330 340 350
YSPKCDLVLD AAHEKSTESS SGPKREEIME SILFKCSDFV VVQFKDMDSS
360 370 380 390 400
YAKRDAFTDS AISAKVNGEH KEKDLEPWDA GELTANEELE ALENDVSNGW
410 420 430 440 450
DPNDMFRYNE ENYGVVSTYD SSLSSYTVPL ERDNSEEFLK REARANQLAE
460 470 480 490 500
EIESSAQYKA RVALENDDRS EEEKYTAVQR NSSEREGHSI NTRENKYIPP
510 520 530 540 550
GQRNREVISW GSGRQNSPRM GQPGSGSMPS RSTSHTSDFN PNSCSDQRVV
560 570 580 590 600
NGGVPWPSPC PSPSSRPPSR YQSGPNSLPP RAATPTRPPS RPPSRPSRPP
610 620 630 640 650
SHPSAHGSPA PVSTMPKRMS SEGPPRMSPK AQRHPRNHRV SAGRGSISSG
660 670 680 690 700
LEFVSHNPPS EAATPPVART SPSGGTWSSV VSGVPRLSPK THRPRSPRQN
710 720 730 740 750
SIGNTPSGPV LASPQAGIIP TEAVAMPIPA ASPTPASPAS NRAVTPSSEA
760 770 780 790 800
KDSRLQDQRQ NSPAGNKENI KPNETSPSFS KAENKGISPI VSEHRKQIDD
810 820 830 840 850
LKKFKNDFRL QPSSTSESMD QLLNKNREAE KSRDLIKDKI EPSAKDSFTE
860 870 880 890 900
NSSSNCTSGS SKPNSPSISP SILSNTEHKR GPEVTSQGVQ TSSPACKQEK
910 920 930 940 950
DDKEEKKDAA EQVRKSTLNP NAKEFNPRSF SQPKPSTTPT SPRPQAQPSP
960 970 980 990 1000
SMVGHQQPTP VYTQPVCFAP NMMYPVPVSP GVQPLYPIPM TPMPVNQAKT
1010 1020 1030 1040 1050
YRAVPNMPQQ RQDQHHQSAM MHPASAAGPP IAATPPAYST QYVAYSPQQF
1060 1070 1080 1090 1100
PNQPLVQHVP HYQSQHPHVY SPVIQGNARM MAPPTHAQPG LVSSSATQYG
1110 1120 1130 1140 1150
AHEQTHAMYA CPKLPYNKET SPSFYFAIST GSLAQQYAHP NATLHPHTPH
1160 1170 1180 1190 1200
PQPSATPTGQ QQSQHGGSHP APSPVQHHQH QAAQALHLAS PQQQSAIYHA
1210 1220 1230 1240 1250
GLAPTPPSMT PASNTQSPQN SFPAAQQTVF TIHPSHVQPA YTNPPHMAHV
1260 1270 1280 1290 1300
PQAHVQSGMV PSHPTAHAPM MLMTTQPPGG PQAALAQSAL QPIPVSTTAH
1310
FPYMTHPSVQ AHHQQQL
Length:1,317
Mass (Da):140,881
Last modified:February 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51F8783AD6DC8F6F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A096MU68A0A096MU68_PAPAN
LsmAD domain-containing protein
ATXN2
1,073Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3LFD9A0A2I3LFD9_PAPAN
LsmAD domain-containing protein
ATXN2
1,006Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3N4C8A0A2I3N4C8_PAPAN
LsmAD domain-containing protein
ATXN2
927Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AHZZ02002985 Genomic DNA No translation available.
AHZZ02002986 Genomic DNA No translation available.
AHZZ02002987 Genomic DNA No translation available.
AHZZ02002988 Genomic DNA No translation available.
AHZZ02002989 Genomic DNA No translation available.
AHZZ02002990 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSPANT00000055532; ENSPANP00000021053; ENSPANG00000017168

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AHZZ02002985 Genomic DNA No translation available.
AHZZ02002986 Genomic DNA No translation available.
AHZZ02002987 Genomic DNA No translation available.
AHZZ02002988 Genomic DNA No translation available.
AHZZ02002989 Genomic DNA No translation available.
AHZZ02002990 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPANT00000055532; ENSPANP00000021053; ENSPANG00000017168

Phylogenomic databases

GeneTreeiENSGT00940000156812

Gene expression databases

ExpressionAtlasiA0A2I3LC85 baseline

Family and domain databases

InterProiView protein in InterPro
IPR009818 Ataxin-2_C
IPR033093 ATXN2
IPR010920 LSM_dom_sf
IPR009604 LsmAD_domain
IPR025852 SM_dom_ATX
PANTHERiPTHR12854:SF11 PTHR12854:SF11, 1 hit
PfamiView protein in Pfam
PF06741 LsmAD, 1 hit
PF07145 PAM2, 1 hit
PF14438 SM-ATX, 1 hit
SMARTiView protein in SMART
SM01272 LsmAD, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2I3LC85_PAPAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2I3LC85
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: July 31, 2019
This is version 12 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again