Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 10 (12 Aug 2020)
Sequence version 1 (28 Feb 2018)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Uncharacterized protein

Gene

TNRC6A

Organism
Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRNA-mediated gene silencingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNRC6AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri61853 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHylobatidaeNomascus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001073 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1045 – 1171Ago_hookInterPro annotationAdd BLAST127
Domaini1474 – 1737TNRC6-PABC_bdgInterPro annotationAdd BLAST264

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 122DisorderedSequence analysisAdd BLAST122
Regioni142 – 260DisorderedSequence analysisAdd BLAST119
Regioni405 – 424DisorderedSequence analysisAdd BLAST20
Regioni463 – 486DisorderedSequence analysisAdd BLAST24
Regioni529 – 1107DisorderedSequence analysisAdd BLAST579
Regioni1133 – 1164DisorderedSequence analysisAdd BLAST32
Regioni1219 – 1242DisorderedSequence analysisAdd BLAST24
Regioni1393 – 1425DisorderedSequence analysisAdd BLAST33
Regioni1546 – 1604DisorderedSequence analysisAdd BLAST59
Regioni1693 – 1715DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi36 – 78PolarSequence analysisAdd BLAST43
Compositional biasi79 – 93Pro-richSequence analysisAdd BLAST15
Compositional biasi142 – 200PolarSequence analysisAdd BLAST59
Compositional biasi225 – 260PolarSequence analysisAdd BLAST36
Compositional biasi529 – 646PolarSequence analysisAdd BLAST118
Compositional biasi647 – 671PolyampholyteSequence analysisAdd BLAST25
Compositional biasi672 – 707PolarSequence analysisAdd BLAST36
Compositional biasi719 – 752PolarSequence analysisAdd BLAST34
Compositional biasi771 – 788PolarSequence analysisAdd BLAST18
Compositional biasi802 – 920PolarSequence analysisAdd BLAST119
Compositional biasi952 – 974PolyampholyteSequence analysisAdd BLAST23
Compositional biasi981 – 1027PolarSequence analysisAdd BLAST47
Compositional biasi1064 – 1089PolarSequence analysisAdd BLAST26
Compositional biasi1695 – 1709Pro-richSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GW182 family.ARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158180

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019486, Argonaute_hook_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033501, TNRC6A

The PANTHER Classification System

More...
PANTHERi
PTHR13020:SF28, PTHR13020:SF28, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10427, Ago_hook, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A2I3HVN3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
AKIAPLHSSL GNKCETLSKK KKKKPLLKAM CSVPEQIKPS VSQPQPANSN
60 70 80 90 100
NGTSTATTTQ PQQQPQQQQQ QQQQPQQQPQ QQPPQPQPQQ QPQQQPQALP
110 120 130 140 150
RYPREVPPRF RHQEHKQLLK RGQHFPVIAA NLGSAVKVLN SQSESSALTN
160 170 180 190 200
QQPQNNGEVQ NSKNQSDINH STSGSHYENP QRGPVSSTSD SSTNCKNAVV
210 220 230 240 250
SDLSEKEAWP SVPGSDPELA SECMDADSAS SSESEKNITI MASGNTGGEK
260 270 280 290 300
DGLRNSTGLG SQNKFVVGSS SNNVGHGSST GPWGFSHGAI ISTCQVSVDA
310 320 330 340 350
PESKSESSNN RMNAWGTVSS SSNGGLNPST LNSNSNHGAW PVLENNGLAL
360 370 380 390 400
KGPVGCGSSG INIQCSTIGQ MPNNQSINSK VSGGSTHGTW GSLQETCESE
410 420 430 440 450
VSGTQKVSFS GQPQNITTEM TGPNNTTNFM TSSLPNSGSV QNNELPSSNT
460 470 480 490 500
GAWRVSTMNH PQMQAPSGMN GTSLSHLSNG ESKSGGSYGT TWGAYGSNYS
510 520 530 540 550
GDKCSGPNGQ ANGDTVNATL MQPGVNGPMG TNFQVNTNKG GGVWESGAAN
560 570 580 590 600
SQSTSWGSGN GANSGGSRRG WGTPAQNTGT NLPSVEWNKL PSNQHSNDSA
610 620 630 640 650
NGNGKTFTNG WKSTEEEDQG SATSQTNEQS SVWAKTGGTV ESDGSTESTG
660 670 680 690 700
RLEEKGTGES QSRDRRKVDQ HTLLQSIVNR TDLDPRVLSN SGWGQTPIKQ
710 720 730 740 750
NTAWDTETSP RGERKTDNGT EAWGSSATQT FNSGACIDKT SPNSNDTSSV
760 770 780 790 800
SGWGDPKPAL RWGDSKGSNC QGGWEDDSAA TGMVKSNQWG NCKEEKAAWN
810 820 830 840 850
DSQKNKQGWG DGQKSSQGWS VSASDNWGET SRSNHWGEAN KKSSSGGSDS
860 870 880 890 900
DRSVSGWNEL GKTSSFTWGN NINPNNSSGW DESSKPTPSQ GWGDPPKSNQ
910 920 930 940 950
SLGWGDSSKP VSSPDWNKQQ DIVGSWGIPP ATGKPPGTGW LGGPIPAPAK
960 970 980 990 1000
EEEPTGWEEP SPESIRRKME IDDGTSAWGD PSKYNYKNVN MWNKNVPNGN
1010 1020 1030 1040 1050
SRSDQQAQVH QLLTPASAIS NKEASSGSGW GEPWGEPSTP ATTVDNGTSA
1060 1070 1080 1090 1100
WGKPIDSGPS WGEPIAAASS TSTWGSSSVG PQALSKSGPK SMQDGWCGDD
1110 1120 1130 1140 1150
MPLPGNRPTG WEEEEDVEIG MWNSNSSQEL NSSLNWPPYT KKMSSKGLSG
1160 1170 1180 1190 1200
KKRRRERGMM KGGNKQEEAW INPFVKQFSN ISFSRDSPEE NVQSNKMDLS
1210 1220 1230 1240 1250
GGMLQDKRME IDKHSLNIGD YNRTVGKGPG SRPQISKESS MERNPYFDKD
1260 1270 1280 1290 1300
GIVADESQNM QFMSSQSMKL PPSNSALPNQ ALGSIAGLGM QNLNSVRQVS
1310 1320 1330 1340 1350
PDYNVAMRCF MFGVGNTAPP AQPLSSSQPN LRAQVPPPLL SPQVPVSLLK
1360 1370 1380 1390 1400
YAPNNGGLNP LFGPQQVAML NQLSQLNQLS QISQLQRLLA QQQRAQSQRS
1410 1420 1430 1440 1450
VPSGNRPQQD QQGRPLSVQQ QMMQQSRQLD PNLLVKQQTP PSQQQPLHQP
1460 1470 1480 1490 1500
VMKSFLDNVM PHTTPELQKG PSPINAFSNF PIGLNSNLNV NMDMNSIKEP
1510 1520 1530 1540 1550
QSRLRKWTTV DSISVNTSLD QNSSKHGAIS SGFRLEESPF VPYDFMNSST
1560 1570 1580 1590 1600
SPASPPGSIG DGWPRAKSPN GSSSVNWPPE FRPGEPWKGY PNIDPETDPY
1610 1620 1630 1640 1650
VTPGSVINNL SINTVREVDH LRDRNSGSSS SLNTTLPSTS AWSSIRASNY
1660 1670 1680 1690 1700
NVPLSSTAQS TSARNSDSKL TWSPGSVTNT SLAHELWKVP LPPKNITAPS
1710 1720 1730 1740 1750
RPPPGLTGQK PPLSTWDNSP LRIGGGWGNS DARYTPGGFL WFICETLTST
1760 1770 1780 1790 1800
NSQIDGSTLR TLCMQHGPLI TFHLNLPHGN ALVRYSSKEE VVKAQKSLHM
1810 1820 1830 1840 1850
CVLGNTTILA EFASEEEISR FFAQSQSLTP SPGWQSLGSS QSRLGSLDCS
1860 1870 1880 1890 1900
HSFSSRTDLN HWNGAGLSGT NCGDLHGTSL WGTPHYSTSL WGPPSSSDPR
1910 1920
GISSPSPINA FLSVDHLGGG GESM
Length:1,924
Mass (Da):205,878
Last modified:February 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i789BD69BF512E36F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G1RMH2G1RMH2_NOMLE
Uncharacterized protein
TNRC6A
1,940Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3HFT6A0A2I3HFT6_NOMLE
Uncharacterized protein
TNRC6A
1,876Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ADFV01197101 Genomic DNA No translation available.
ADFV01197102 Genomic DNA No translation available.
ADFV01197103 Genomic DNA No translation available.
ADFV01197104 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSNLET00000037054; ENSNLEP00000047605; ENSNLEG00000011851

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADFV01197101 Genomic DNA No translation available.
ADFV01197102 Genomic DNA No translation available.
ADFV01197103 Genomic DNA No translation available.
ADFV01197104 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSNLET00000037054; ENSNLEP00000047605; ENSNLEG00000011851

Phylogenomic databases

GeneTreeiENSGT00940000158180

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR019486, Argonaute_hook_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033501, TNRC6A
PANTHERiPTHR13020:SF28, PTHR13020:SF28, 1 hit
PfamiView protein in Pfam
PF10427, Ago_hook, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2I3HVN3_NOMLE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2I3HVN3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: August 12, 2020
This is version 10 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again