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UniProtKB - A0A2I3HVN3 (A0A2I3HVN3_NOMLE)

Entry version 10 (12 Aug 2020)
Sequence version 1 (28 Feb 2018)
Previous versions | rss
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Protein
Submitted name:

Uncharacterized protein

Gene

TNRC6A

Organism
Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRNA-mediated gene silencingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNRC6AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri61853 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hylobatidae › Nomascus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001073 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1045 – 1171Ago_hookInterPro annotationAdd BLAST127
Domaini1474 – 1737TNRC6-PABC_bdgInterPro annotationAdd BLAST264

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 122DisorderedSequence analysisAdd BLAST122
Regioni142 – 260DisorderedSequence analysisAdd BLAST119
Regioni405 – 424DisorderedSequence analysisAdd BLAST20
Regioni463 – 486DisorderedSequence analysisAdd BLAST24
Regioni529 – 1107DisorderedSequence analysisAdd BLAST579
Regioni1133 – 1164DisorderedSequence analysisAdd BLAST32
Regioni1219 – 1242DisorderedSequence analysisAdd BLAST24
Regioni1393 – 1425DisorderedSequence analysisAdd BLAST33
Regioni1546 – 1604DisorderedSequence analysisAdd BLAST59
Regioni1693 – 1715DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi36 – 78PolarSequence analysisAdd BLAST43
Compositional biasi79 – 93Pro-richSequence analysisAdd BLAST15
Compositional biasi142 – 200PolarSequence analysisAdd BLAST59
Compositional biasi225 – 260PolarSequence analysisAdd BLAST36
Compositional biasi529 – 646PolarSequence analysisAdd BLAST118
Compositional biasi647 – 671PolyampholyteSequence analysisAdd BLAST25
Compositional biasi672 – 707PolarSequence analysisAdd BLAST36
Compositional biasi719 – 752PolarSequence analysisAdd BLAST34
Compositional biasi771 – 788PolarSequence analysisAdd BLAST18
Compositional biasi802 – 920PolarSequence analysisAdd BLAST119
Compositional biasi952 – 974PolyampholyteSequence analysisAdd BLAST23
Compositional biasi981 – 1027PolarSequence analysisAdd BLAST47
Compositional biasi1064 – 1089PolarSequence analysisAdd BLAST26
Compositional biasi1695 – 1709Pro-richSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GW182 family.ARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158180

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019486, Argonaute_hook_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033501, TNRC6A

The PANTHER Classification System

More...PANTHERi		PTHR13020:SF28, PTHR13020:SF28, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10427, Ago_hook, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928, SSF54928, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A2I3HVN3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
AKIAPLHSSL GNKCETLSKK KKKKPLLKAM CSVPEQIKPS VSQPQPANSN 
        60         70         80         90        100
NGTSTATTTQ PQQQPQQQQQ QQQQPQQQPQ QQPPQPQPQQ QPQQQPQALP 
       110        120        130        140        150
RYPREVPPRF RHQEHKQLLK RGQHFPVIAA NLGSAVKVLN SQSESSALTN 
       160        170        180        190        200
QQPQNNGEVQ NSKNQSDINH STSGSHYENP QRGPVSSTSD SSTNCKNAVV 
       210        220        230        240        250
SDLSEKEAWP SVPGSDPELA SECMDADSAS SSESEKNITI MASGNTGGEK 
       260        270        280        290        300
DGLRNSTGLG SQNKFVVGSS SNNVGHGSST GPWGFSHGAI ISTCQVSVDA 
       310        320        330        340        350
PESKSESSNN RMNAWGTVSS SSNGGLNPST LNSNSNHGAW PVLENNGLAL 
       360        370        380        390        400
KGPVGCGSSG INIQCSTIGQ MPNNQSINSK VSGGSTHGTW GSLQETCESE 
       410        420        430        440        450
VSGTQKVSFS GQPQNITTEM TGPNNTTNFM TSSLPNSGSV QNNELPSSNT 
       460        470        480        490        500
GAWRVSTMNH PQMQAPSGMN GTSLSHLSNG ESKSGGSYGT TWGAYGSNYS 
       510        520        530        540        550
GDKCSGPNGQ ANGDTVNATL MQPGVNGPMG TNFQVNTNKG GGVWESGAAN 
       560        570        580        590        600
SQSTSWGSGN GANSGGSRRG WGTPAQNTGT NLPSVEWNKL PSNQHSNDSA 
       610        620        630        640        650
NGNGKTFTNG WKSTEEEDQG SATSQTNEQS SVWAKTGGTV ESDGSTESTG 
       660        670        680        690        700
RLEEKGTGES QSRDRRKVDQ HTLLQSIVNR TDLDPRVLSN SGWGQTPIKQ 
       710        720        730        740        750
NTAWDTETSP RGERKTDNGT EAWGSSATQT FNSGACIDKT SPNSNDTSSV 
       760        770        780        790        800
SGWGDPKPAL RWGDSKGSNC QGGWEDDSAA TGMVKSNQWG NCKEEKAAWN 
       810        820        830        840        850
DSQKNKQGWG DGQKSSQGWS VSASDNWGET SRSNHWGEAN KKSSSGGSDS 
       860        870        880        890        900
DRSVSGWNEL GKTSSFTWGN NINPNNSSGW DESSKPTPSQ GWGDPPKSNQ 
       910        920        930        940        950
SLGWGDSSKP VSSPDWNKQQ DIVGSWGIPP ATGKPPGTGW LGGPIPAPAK 
       960        970        980        990       1000
EEEPTGWEEP SPESIRRKME IDDGTSAWGD PSKYNYKNVN MWNKNVPNGN 
      1010       1020       1030       1040       1050
SRSDQQAQVH QLLTPASAIS NKEASSGSGW GEPWGEPSTP ATTVDNGTSA 
      1060       1070       1080       1090       1100
WGKPIDSGPS WGEPIAAASS TSTWGSSSVG PQALSKSGPK SMQDGWCGDD 
      1110       1120       1130       1140       1150
MPLPGNRPTG WEEEEDVEIG MWNSNSSQEL NSSLNWPPYT KKMSSKGLSG 
      1160       1170       1180       1190       1200
KKRRRERGMM KGGNKQEEAW INPFVKQFSN ISFSRDSPEE NVQSNKMDLS 
      1210       1220       1230       1240       1250
GGMLQDKRME IDKHSLNIGD YNRTVGKGPG SRPQISKESS MERNPYFDKD 
      1260       1270       1280       1290       1300
GIVADESQNM QFMSSQSMKL PPSNSALPNQ ALGSIAGLGM QNLNSVRQVS 
      1310       1320       1330       1340       1350
PDYNVAMRCF MFGVGNTAPP AQPLSSSQPN LRAQVPPPLL SPQVPVSLLK 
      1360       1370       1380       1390       1400
YAPNNGGLNP LFGPQQVAML NQLSQLNQLS QISQLQRLLA QQQRAQSQRS 
      1410       1420       1430       1440       1450
VPSGNRPQQD QQGRPLSVQQ QMMQQSRQLD PNLLVKQQTP PSQQQPLHQP 
      1460       1470       1480       1490       1500
VMKSFLDNVM PHTTPELQKG PSPINAFSNF PIGLNSNLNV NMDMNSIKEP 
      1510       1520       1530       1540       1550
QSRLRKWTTV DSISVNTSLD QNSSKHGAIS SGFRLEESPF VPYDFMNSST 
      1560       1570       1580       1590       1600
SPASPPGSIG DGWPRAKSPN GSSSVNWPPE FRPGEPWKGY PNIDPETDPY 
      1610       1620       1630       1640       1650
VTPGSVINNL SINTVREVDH LRDRNSGSSS SLNTTLPSTS AWSSIRASNY 
      1660       1670       1680       1690       1700
NVPLSSTAQS TSARNSDSKL TWSPGSVTNT SLAHELWKVP LPPKNITAPS 
      1710       1720       1730       1740       1750
RPPPGLTGQK PPLSTWDNSP LRIGGGWGNS DARYTPGGFL WFICETLTST 
      1760       1770       1780       1790       1800
NSQIDGSTLR TLCMQHGPLI TFHLNLPHGN ALVRYSSKEE VVKAQKSLHM 
      1810       1820       1830       1840       1850
CVLGNTTILA EFASEEEISR FFAQSQSLTP SPGWQSLGSS QSRLGSLDCS 
      1860       1870       1880       1890       1900
HSFSSRTDLN HWNGAGLSGT NCGDLHGTSL WGTPHYSTSL WGPPSSSDPR 
      1910       1920 
GISSPSPINA FLSVDHLGGG GESM
Length:1,924
Mass (Da):205,878
Last modified:February 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i789BD69BF512E36F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G1RMH2G1RMH2_NOMLE
Uncharacterized protein
TNRC6A
1,940Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3HFT6A0A2I3HFT6_NOMLE
Uncharacterized protein
TNRC6A
1,876Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
ADFV01197101 Genomic DNA No translation available.
ADFV01197102 Genomic DNA No translation available.
ADFV01197103 Genomic DNA No translation available.
ADFV01197104 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSNLET00000037054; ENSNLEP00000047605; ENSNLEG00000011851

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADFV01197101 Genomic DNA No translation available.
ADFV01197102 Genomic DNA No translation available.
ADFV01197103 Genomic DNA No translation available.
ADFV01197104 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSNLET00000037054; ENSNLEP00000047605; ENSNLEG00000011851

Phylogenomic databases

GeneTreeiENSGT00940000158180

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR019486, Argonaute_hook_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033501, TNRC6A
PANTHERiPTHR13020:SF28, PTHR13020:SF28, 1 hit
PfamiView protein in Pfam
PF10427, Ago_hook, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2I3HVN3_NOMLE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2I3HVN3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: August 12, 2020
This is version 10 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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