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Entry version 18 (10 Feb 2021)
Sequence version 1 (28 Feb 2018)
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Protein
Submitted name:

Uncharacterized protein

Gene

AFDN

Organism
Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesionARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AFDNImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri61853 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHylobatidaeNomascus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001073 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 131Ras-associatingInterPro annotationAdd BLAST95
Domaini244 – 346Ras-associatingInterPro annotationAdd BLAST103
Domaini666 – 913DiluteInterPro annotationAdd BLAST248
Domaini1012 – 1098PDZInterPro annotationAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni126 – 192DisorderedSequence analysisAdd BLAST67
Regioni347 – 376DisorderedSequence analysisAdd BLAST30
Regioni537 – 593DisorderedSequence analysisAdd BLAST57
Regioni1112 – 1465DisorderedSequence analysisAdd BLAST354
Regioni1573 – 1592DisorderedSequence analysisAdd BLAST20
Regioni1606 – 1822DisorderedSequence analysisAdd BLAST217

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi141 – 192PolyampholyteSequence analysisAdd BLAST52
Compositional biasi347 – 367PolyampholyteSequence analysisAdd BLAST21
Compositional biasi542 – 566PolarSequence analysisAdd BLAST25
Compositional biasi1134 – 1150PolarSequence analysisAdd BLAST17
Compositional biasi1159 – 1174PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1176 – 1214PolarSequence analysisAdd BLAST39
Compositional biasi1230 – 1251PolarSequence analysisAdd BLAST22
Compositional biasi1279 – 1305PolyampholyteSequence analysisAdd BLAST27
Compositional biasi1307 – 1345PolarSequence analysisAdd BLAST39
Compositional biasi1365 – 1380Pro-richSequence analysisAdd BLAST16
Compositional biasi1411 – 1447PolyampholyteSequence analysisAdd BLAST37
Compositional biasi1448 – 1465PolarSequence analysisAdd BLAST18
Compositional biasi1606 – 1674PolyampholyteSequence analysisAdd BLAST69
Compositional biasi1680 – 1709Pro-richSequence analysisAdd BLAST30
Compositional biasi1760 – 1774PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1775 – 1806PolarSequence analysisAdd BLAST32
Compositional biasi1807 – 1822PolyampholyteSequence analysisAdd BLAST16

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155237

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00060, FHA, 1 hit
cd15471, Myo5p-like_CBD_afadin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037977, CBD_Afadin
IPR002710, Dilute_dom
IPR000253, FHA_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000159, RA_dom
IPR008984, SMAD_FHA_dom_sf
IPR029071, Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01843, DIL, 1 hit
PF00498, FHA, 1 hit
PF00595, PDZ, 1 hit
PF00788, RA, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01132, DIL, 1 hit
SM00240, FHA, 1 hit
SM00228, PDZ, 1 hit
SM00314, RA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49879, SSF49879, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51126, DILUTE, 1 hit
PS50106, PDZ, 1 hit
PS50200, RA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A2I3GKQ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
IAKPTILHHH NISFKNEEFS FIRISGWDQH FPLDLEFHGV MRFYFQDKAA
60 70 80 90 100
GNFATKCIRV SSTATTQDVI ETLAEKFRPD MRMLSSPKYS LYEVHVSGER
110 120 130 140 150
RLDIDEKPLV VQLNWNKDDR EGRFVLKNEN DAIPPKKAQS NGPEKQEKEG
160 170 180 190 200
VIQNFKRTLS KKEKKEKKKR EKEALRQASD KDDRPFQGED VENSRLAAEV
210 220 230 240 250
YKDMPETSFT RTISNPEVVM KRRRQQKLEK RMQEFRSSDG RPDSGGTLRI
260 270 280 290 300
YADSLKPNIP YKTILLSTTD PADFAVAEAL EKYGLEKENP KDYCIARVML
310 320 330 340 350
PPGAQHSDEK GAKEIILDDD ECPLQIFREW PSDKGILVFQ LKRRPPDHIP
360 370 380 390 400
KKTKKHLEGK TPKGKERADG SGYGSTLPPE KLPYLVELSP GRRNHFAYYN
410 420 430 440 450
YHTYEDGSDS RDKPKLYRLQ LSVTEVGTEK LDDNSIQLFG PGIQPHHCDL
460 470 480 490 500
TNMDGVVTVT PRSMDAETYV EGQRISETTM LQSGMKVQFG ASHVFKFVDP
510 520 530 540 550
SQDHALAKRS VDGGLMVKGP KHKPGIVQET TFDLGGDIHS GTALPTSKST
560 570 580 590 600
TRLDSDRVSS ASSTAERGMV KPMIRVEQQP DYRRQESRTQ DASGPELILP
610 620 630 640 650
ASIEFRESSE DSFLSAIINY TNSSTVHFKL SPTYVLYMAC RYVLSNQYRP
660 670 680 690 700
DISPTERTHK VIAVVNKMVS MMEGVIQEVD QVDQKQKNIA GALAFWMANA
710 720 730 740 750
SELLNFIKQD RDLSRITLDA QDVLAHLVQM AFKYLVHCLQ SELNNYMPAF
760 770 780 790 800
LDDPEENSLQ RPKIDDVLHT LTGAMSLLRR CRVNAALTIQ LFSQLFHFIN
810 820 830 840 850
MWLFNRLVTD PDSGLCSHYW GAIIRQQLGH IEAWAEKQGL ELAADCHLSR
860 870 880 890 900
IVQATTLLTM DKYAPDDIPN INSTCFKLNS LQLQALLQNY HCAPDEPFIP
910 920 930 940 950
TDLIENVVAV AENTADELAR SDGREVQLEE DPDLQLPFLL PEDGYSCDVV
960 970 980 990 1000
RNIPNGLQEF LDPLCQRGFC RLIPHTRSPG TWTIYFEGAD YESHLLRENT
1010 1020 1030 1040 1050
ELAQPLRKEP EIITVTLKKQ NGMGLSIVAA KGAGQDKLGI YVKSVVKGGA
1060 1070 1080 1090 1100
ADVDGRLAAG DQLLSVDGRS LVGLSQERAA ELMTRTSSVV TLEVAKQGAI
1110 1120 1130 1140 1150
YHGLATLLNQ PSPMMQRISD RRGSGKPRPK SEGFELYNNS TQNGSPESPQ
1160 1170 1180 1190 1200
LPWAEYSEPK KLPGDDRLMK NRADHRSSPN VANQPPSPGG KSAYASGTTA
1210 1220 1230 1240 1250
KITSVSTGNL CTEEQTPPPR PEAYPIPTQT YTREYFTFPA SKSQDRMAPP
1260 1270 1280 1290 1300
QNQWPNYEEK PHMHTDSNHS SIAIQRVTRS QEELREDKAY QLERHRIEAA
1310 1320 1330 1340 1350
MDRKSDSDMW INQSSSLDSS TSSQEHLNHS SKSVTPASTL TKSGPGRWKT
1360 1370 1380 1390 1400
PAAIPATPVA VSQPIRTDLP PPPPPPPVHY AGDFDGMSMD LPLPPPPSAN
1410 1420 1430 1440 1450
QIGLPSAQVA AAERKKREEH QRWYEKEKAR LEEERERKRR EQERKLGQMR
1460 1470 1480 1490 1500
TQSLNPAPFS PLTAQQMKPE KPSTLQRPQE TVIRELQPQQ QPRTIERRDL
1510 1520 1530 1540 1550
QYITVSKEFH HMXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXRSAE
1560 1570 1580 1590 1600
ESDRLRKLML EWQFQKRLQE SKQKDVDDEE EEDDDVDTML IMQRLEAERR
1610 1620 1630 1640 1650
ARLQDEERRR QQQLEEMRKR EAEDRARQEE ERRRQEEERT KRDAEEKRRQ
1660 1670 1680 1690 1700
EEGYYSRLEA ERRRQHDEAA RRLLEPEAPG LCRPPLPRDY EPPSPSLAPG
1710 1720 1730 1740 1750
APPPPPQRNA SYLKTQVLSP DSLFTAKFVA YNEEEEEEDC SLAGPNSYPG
1760 1770 1780 1790 1800
STGAAVGAHD AYRDAKEKRS KSQDADSPGS SGAPENLTFK ERQRLFSQGQ
1810 1820
DVSNKVKASR KLTELENELN TK
Length:1,822
Mass (Da):206,564
Last modified:February 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB7E1B3FB44365111
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G1QHN0G1QHN0_NOMLE
Uncharacterized protein
AFDN
1,787Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3HBE0A0A2I3HBE0_NOMLE
Uncharacterized protein
AFDN
1,815Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3HZ68A0A2I3HZ68_NOMLE
Uncharacterized protein
AFDN
1,744Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ADFV01132747 Genomic DNA No translation available.
ADFV01132748 Genomic DNA No translation available.
ADFV01132749 Genomic DNA No translation available.
ADFV01132750 Genomic DNA No translation available.
ADFV01132751 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSNLET00000049765; ENSNLEP00000031898; ENSNLEG00000000333

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADFV01132747 Genomic DNA No translation available.
ADFV01132748 Genomic DNA No translation available.
ADFV01132749 Genomic DNA No translation available.
ADFV01132750 Genomic DNA No translation available.
ADFV01132751 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Genome annotation databases

EnsembliENSNLET00000049765; ENSNLEP00000031898; ENSNLEG00000000333

Phylogenomic databases

GeneTreeiENSGT00940000155237

Family and domain databases

CDDicd00060, FHA, 1 hit
cd15471, Myo5p-like_CBD_afadin, 1 hit
Gene3Di2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR037977, CBD_Afadin
IPR002710, Dilute_dom
IPR000253, FHA_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000159, RA_dom
IPR008984, SMAD_FHA_dom_sf
IPR029071, Ubiquitin-like_domsf
PfamiView protein in Pfam
PF01843, DIL, 1 hit
PF00498, FHA, 1 hit
PF00595, PDZ, 1 hit
PF00788, RA, 2 hits
SMARTiView protein in SMART
SM01132, DIL, 1 hit
SM00240, FHA, 1 hit
SM00228, PDZ, 1 hit
SM00314, RA, 2 hits
SUPFAMiSSF49879, SSF49879, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS51126, DILUTE, 1 hit
PS50106, PDZ, 1 hit
PS50200, RA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2I3GKQ2_NOMLE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2I3GKQ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: February 10, 2021
This is version 18 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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