UniProtKB - A0A2I3GKQ2 (A0A2I3GKQ2_NOMLE)
Protein
Submitted name:
Uncharacterized protein
Gene
AFDN
Organism
Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)
Status
Functioni
GO - Molecular functioni
- actin filament binding Source: Ensembl
- Ras GTPase binding Source: Ensembl
GO - Biological processi
- bicellular tight junction assembly Source: Ensembl
- cell adhesion Source: UniProtKB-KW
- establishment of endothelial intestinal barrier Source: Ensembl
- negative regulation of cell migration Source: Ensembl
- pore complex assembly Source: Ensembl
- positive regulation of cell-cell adhesion mediated by cadherin Source: Ensembl
- positive regulation of gene expression Source: Ensembl
- positive regulation of GTPase activity Source: Ensembl
- signal transduction Source: InterPro
Keywordsi
Biological process | Cell adhesionARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Uncharacterized proteinImported |
Gene namesi | Name:AFDNImported |
Organismi | Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)Imported |
Taxonomic identifieri | 61853 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hylobatidae › Nomascus |
Proteomesi |
|
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Nucleus
- nuclear speck Source: Ensembl
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- cell-cell contact zone Source: Ensembl
- pore complex Source: Ensembl
- tight junction Source: Ensembl
Interactioni
GO - Molecular functioni
- actin filament binding Source: Ensembl
- Ras GTPase binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 37 – 131 | Ras-associatingInterPro annotationAdd BLAST | 95 | |
Domaini | 244 – 346 | Ras-associatingInterPro annotationAdd BLAST | 103 | |
Domaini | 666 – 913 | DiluteInterPro annotationAdd BLAST | 248 | |
Domaini | 1012 – 1098 | PDZInterPro annotationAdd BLAST | 87 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 126 – 192 | DisorderedSequence analysisAdd BLAST | 67 | |
Regioni | 347 – 376 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 537 – 593 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 1112 – 1465 | DisorderedSequence analysisAdd BLAST | 354 | |
Regioni | 1573 – 1592 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1606 – 1822 | DisorderedSequence analysisAdd BLAST | 217 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 141 – 192 | PolyampholyteSequence analysisAdd BLAST | 52 | |
Compositional biasi | 347 – 367 | PolyampholyteSequence analysisAdd BLAST | 21 | |
Compositional biasi | 542 – 566 | PolarSequence analysisAdd BLAST | 25 | |
Compositional biasi | 1134 – 1150 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1159 – 1174 | PolyampholyteSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1176 – 1214 | PolarSequence analysisAdd BLAST | 39 | |
Compositional biasi | 1230 – 1251 | PolarSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1279 – 1305 | PolyampholyteSequence analysisAdd BLAST | 27 | |
Compositional biasi | 1307 – 1345 | PolarSequence analysisAdd BLAST | 39 | |
Compositional biasi | 1365 – 1380 | Pro-richSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1411 – 1447 | PolyampholyteSequence analysisAdd BLAST | 37 | |
Compositional biasi | 1448 – 1465 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1606 – 1674 | PolyampholyteSequence analysisAdd BLAST | 69 | |
Compositional biasi | 1680 – 1709 | Pro-richSequence analysisAdd BLAST | 30 | |
Compositional biasi | 1760 – 1774 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1775 – 1806 | PolarSequence analysisAdd BLAST | 32 | |
Compositional biasi | 1807 – 1822 | PolyampholyteSequence analysisAdd BLAST | 16 |
Phylogenomic databases
GeneTreei | ENSGT00940000155237 |
Family and domain databases
CDDi | cd00060, FHA, 1 hit cd15471, Myo5p-like_CBD_afadin, 1 hit |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR037977, CBD_Afadin IPR002710, Dilute_dom IPR000253, FHA_dom IPR001478, PDZ IPR036034, PDZ_sf IPR000159, RA_dom IPR008984, SMAD_FHA_dom_sf IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF01843, DIL, 1 hit PF00498, FHA, 1 hit PF00595, PDZ, 1 hit PF00788, RA, 2 hits |
SMARTi | View protein in SMART SM01132, DIL, 1 hit SM00240, FHA, 1 hit SM00228, PDZ, 1 hit SM00314, RA, 2 hits |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 2 hits |
PROSITEi | View protein in PROSITE PS51126, DILUTE, 1 hit PS50106, PDZ, 1 hit PS50200, RA, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
A0A2I3GKQ2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
IAKPTILHHH NISFKNEEFS FIRISGWDQH FPLDLEFHGV MRFYFQDKAA
60 70 80 90 100
GNFATKCIRV SSTATTQDVI ETLAEKFRPD MRMLSSPKYS LYEVHVSGER
110 120 130 140 150
RLDIDEKPLV VQLNWNKDDR EGRFVLKNEN DAIPPKKAQS NGPEKQEKEG
160 170 180 190 200
VIQNFKRTLS KKEKKEKKKR EKEALRQASD KDDRPFQGED VENSRLAAEV
210 220 230 240 250
YKDMPETSFT RTISNPEVVM KRRRQQKLEK RMQEFRSSDG RPDSGGTLRI
260 270 280 290 300
YADSLKPNIP YKTILLSTTD PADFAVAEAL EKYGLEKENP KDYCIARVML
310 320 330 340 350
PPGAQHSDEK GAKEIILDDD ECPLQIFREW PSDKGILVFQ LKRRPPDHIP
360 370 380 390 400
KKTKKHLEGK TPKGKERADG SGYGSTLPPE KLPYLVELSP GRRNHFAYYN
410 420 430 440 450
YHTYEDGSDS RDKPKLYRLQ LSVTEVGTEK LDDNSIQLFG PGIQPHHCDL
460 470 480 490 500
TNMDGVVTVT PRSMDAETYV EGQRISETTM LQSGMKVQFG ASHVFKFVDP
510 520 530 540 550
SQDHALAKRS VDGGLMVKGP KHKPGIVQET TFDLGGDIHS GTALPTSKST
560 570 580 590 600
TRLDSDRVSS ASSTAERGMV KPMIRVEQQP DYRRQESRTQ DASGPELILP
610 620 630 640 650
ASIEFRESSE DSFLSAIINY TNSSTVHFKL SPTYVLYMAC RYVLSNQYRP
660 670 680 690 700
DISPTERTHK VIAVVNKMVS MMEGVIQEVD QVDQKQKNIA GALAFWMANA
710 720 730 740 750
SELLNFIKQD RDLSRITLDA QDVLAHLVQM AFKYLVHCLQ SELNNYMPAF
760 770 780 790 800
LDDPEENSLQ RPKIDDVLHT LTGAMSLLRR CRVNAALTIQ LFSQLFHFIN
810 820 830 840 850
MWLFNRLVTD PDSGLCSHYW GAIIRQQLGH IEAWAEKQGL ELAADCHLSR
860 870 880 890 900
IVQATTLLTM DKYAPDDIPN INSTCFKLNS LQLQALLQNY HCAPDEPFIP
910 920 930 940 950
TDLIENVVAV AENTADELAR SDGREVQLEE DPDLQLPFLL PEDGYSCDVV
960 970 980 990 1000
RNIPNGLQEF LDPLCQRGFC RLIPHTRSPG TWTIYFEGAD YESHLLRENT
1010 1020 1030 1040 1050
ELAQPLRKEP EIITVTLKKQ NGMGLSIVAA KGAGQDKLGI YVKSVVKGGA
1060 1070 1080 1090 1100
ADVDGRLAAG DQLLSVDGRS LVGLSQERAA ELMTRTSSVV TLEVAKQGAI
1110 1120 1130 1140 1150
YHGLATLLNQ PSPMMQRISD RRGSGKPRPK SEGFELYNNS TQNGSPESPQ
1160 1170 1180 1190 1200
LPWAEYSEPK KLPGDDRLMK NRADHRSSPN VANQPPSPGG KSAYASGTTA
1210 1220 1230 1240 1250
KITSVSTGNL CTEEQTPPPR PEAYPIPTQT YTREYFTFPA SKSQDRMAPP
1260 1270 1280 1290 1300
QNQWPNYEEK PHMHTDSNHS SIAIQRVTRS QEELREDKAY QLERHRIEAA
1310 1320 1330 1340 1350
MDRKSDSDMW INQSSSLDSS TSSQEHLNHS SKSVTPASTL TKSGPGRWKT
1360 1370 1380 1390 1400
PAAIPATPVA VSQPIRTDLP PPPPPPPVHY AGDFDGMSMD LPLPPPPSAN
1410 1420 1430 1440 1450
QIGLPSAQVA AAERKKREEH QRWYEKEKAR LEEERERKRR EQERKLGQMR
1460 1470 1480 1490 1500
TQSLNPAPFS PLTAQQMKPE KPSTLQRPQE TVIRELQPQQ QPRTIERRDL
1510 1520 1530 1540 1550
QYITVSKEFH HMXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXRSAE
1560 1570 1580 1590 1600
ESDRLRKLML EWQFQKRLQE SKQKDVDDEE EEDDDVDTML IMQRLEAERR
1610 1620 1630 1640 1650
ARLQDEERRR QQQLEEMRKR EAEDRARQEE ERRRQEEERT KRDAEEKRRQ
1660 1670 1680 1690 1700
EEGYYSRLEA ERRRQHDEAA RRLLEPEAPG LCRPPLPRDY EPPSPSLAPG
1710 1720 1730 1740 1750
APPPPPQRNA SYLKTQVLSP DSLFTAKFVA YNEEEEEEDC SLAGPNSYPG
1760 1770 1780 1790 1800
STGAAVGAHD AYRDAKEKRS KSQDADSPGS SGAPENLTFK ERQRLFSQGQ
1810 1820
DVSNKVKASR KLTELENELN TK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG1QHN0 | G1QHN0_NOMLE | Uncharacterized protein | AFDN | 1,787 | Annotation score: | ||
A0A2I3HBE0 | A0A2I3HBE0_NOMLE | Uncharacterized protein | AFDN | 1,815 | Annotation score: | ||
A0A2I3HZ68 | A0A2I3HZ68_NOMLE | Uncharacterized protein | AFDN | 1,744 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | ADFV01132747 Genomic DNA No translation available. ADFV01132748 Genomic DNA No translation available. ADFV01132749 Genomic DNA No translation available. ADFV01132750 Genomic DNA No translation available. ADFV01132751 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSNLET00000049765; ENSNLEP00000031898; ENSNLEG00000000333 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | ADFV01132747 Genomic DNA No translation available. ADFV01132748 Genomic DNA No translation available. ADFV01132749 Genomic DNA No translation available. ADFV01132750 Genomic DNA No translation available. ADFV01132751 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Genome annotation databases
Ensembli | ENSNLET00000049765; ENSNLEP00000031898; ENSNLEG00000000333 |
Phylogenomic databases
GeneTreei | ENSGT00940000155237 |
Family and domain databases
CDDi | cd00060, FHA, 1 hit cd15471, Myo5p-like_CBD_afadin, 1 hit |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR037977, CBD_Afadin IPR002710, Dilute_dom IPR000253, FHA_dom IPR001478, PDZ IPR036034, PDZ_sf IPR000159, RA_dom IPR008984, SMAD_FHA_dom_sf IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF01843, DIL, 1 hit PF00498, FHA, 1 hit PF00595, PDZ, 1 hit PF00788, RA, 2 hits |
SMARTi | View protein in SMART SM01132, DIL, 1 hit SM00240, FHA, 1 hit SM00228, PDZ, 1 hit SM00314, RA, 2 hits |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 2 hits |
PROSITEi | View protein in PROSITE PS51126, DILUTE, 1 hit PS50106, PDZ, 1 hit PS50200, RA, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A2I3GKQ2_NOMLE | |
Accessioni | A0A2I3GKQ2Primary (citable) accession number: A0A2I3GKQ2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 28, 2018 |
Last sequence update: | February 28, 2018 | |
Last modified: | February 10, 2021 | |
This is version 18 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |