Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Deoxyribonuclease

Gene

DNASE1

Organism
Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei100UniRule annotation1
Active sitei155UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonucleaseUniRule annotation, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
DeoxyribonucleaseUniRule annotation
Gene namesi
Name:DNASE1Imported
OrganismiNomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)Imported
Taxonomic identifieri61853 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHylobatidaeNomascus
Proteomesi
  • UP000001073 Componenti: Chromosome 18

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501413808623 – 281DeoxyribonucleaseSequence analysisAdd BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi123 ↔ 126UniRule annotation
Disulfide bondi194 ↔ 230Essential for enzymatic activityUniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 266Endo/exonuclease/phosphataseInterPro annotationAdd BLAST221

Sequence similaritiesi

Belongs to the DNase I family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00390000013146
KOiK11994

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR018057 Deoxyribonuclease-1_AS
IPR016202 DNase_I
IPR033125 DNASE_I_2
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
PIRSFiPIRSF000988 DNase_I_euk, 1 hit
PRINTSiPR00130 DNASEI
SMARTiView protein in SMART
SM00476 DNaseIc, 1 hit
SUPFAMiSSF56219 SSF56219, 1 hit
PROSITEiView protein in PROSITE
PS00919 DNASE_I_1, 1 hit
PS00918 DNASE_I_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

A0A2I3G7L4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGMRLLGAV LALAALLQGA MSLKIAAFNI QTFGETKMSN ATLVSYIVQI
60 70 80 90 100
LSRYDIALVQ EVRDSHLTAV GKLLDNLNQD APDTYHYVVS EPLGRNSYKE
110 120 130 140 150
RYLFVYRPDQ VSVVDSYYYD DGCEPCGNDT FSREPAIVRF SQVTEVREFA
160 170 180 190 200
IVPLHAAPED AVAEIDALYD VYLDVQEKWG LEDIMLMGDF NAGCSYVRPS
210 220 230 240 250
QWSSIRLRTS PTFQWLIPDT ADTTATSTHC AYDRIVVAGM LLQGAVVPDS
260 270 280
ALPFNFQAAY GLSDQLAQAI SDHYPVEVML K
Length:281
Mass (Da):31,290
Last modified:February 28, 2018 - v1
Checksum:iB8C78060ABFC6A01
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3H8Z9A0A2I3H8Z9_NOMLE
Deoxyribonuclease 1
DNASE1
60Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADFV01048464 Genomic DNA No translation available.
RefSeqiXP_003269266.1, XM_003269218.3

Genome annotation databases

EnsembliENSNLET00000044854; ENSNLEP00000027410; ENSNLEG00000036054
GeneIDi100596660
KEGGinle:100596660

Similar proteinsi

Entry informationi

Entry nameiA0A2I3G7L4_NOMLE
AccessioniPrimary (citable) accession number: A0A2I3G7L4
Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: September 12, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again