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Entry version 19 (12 Aug 2020)
Sequence version 1 (28 Feb 2018)
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Protein
Submitted name:

E3 ubiquitin-protein ligase UBR5

Gene

Ubr5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2767Glycyl thioester intermediatePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1177 – 1245UBR-typePROSITE-ProRule annotationAdd BLAST69

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathwayPROSITE-ProRule annotationARBA annotation
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
E3 ubiquitin-protein ligase UBR5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ubr5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1918040, Ubr5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A0A2I3BQS6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A0A2I3BQS6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A2I3BQS6, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A2I3BQS6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1177 – 1245UBR-typeInterPro annotationAdd BLAST69
Domaini2377 – 2454PABCInterPro annotationAdd BLAST78
Domaini2503 – 2798HECTInterPro annotationAdd BLAST296

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni77 – 175DisorderedSequence analysisAdd BLAST99
Regioni328 – 353DisorderedSequence analysisAdd BLAST26
Regioni583 – 648DisorderedSequence analysisAdd BLAST66
Regioni999 – 1035DisorderedSequence analysisAdd BLAST37
Regioni1052 – 1075DisorderedSequence analysisAdd BLAST24
Regioni1299 – 1318DisorderedSequence analysisAdd BLAST20
Regioni1515 – 1740DisorderedSequence analysisAdd BLAST226
Regioni1859 – 1892DisorderedSequence analysisAdd BLAST34
Regioni1984 – 2021DisorderedSequence analysisAdd BLAST38
Regioni2117 – 2143DisorderedSequence analysisAdd BLAST27
Regioni2323 – 2393DisorderedSequence analysisAdd BLAST71
Regioni2473 – 2500DisorderedSequence analysisAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili15 – 35Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi87 – 151PolarSequence analysisAdd BLAST65
Compositional biasi328 – 344PolyampholyteSequence analysisAdd BLAST17
Compositional biasi583 – 602PolyampholyteSequence analysisAdd BLAST20
Compositional biasi611 – 632PolarSequence analysisAdd BLAST22
Compositional biasi1017 – 1031Pro-richSequence analysisAdd BLAST15
Compositional biasi1052 – 1072PolarSequence analysisAdd BLAST21
Compositional biasi1522 – 1551PolarSequence analysisAdd BLAST30
Compositional biasi1563 – 1577AcidicSequence analysisAdd BLAST15
Compositional biasi1578 – 1608PolyampholyteSequence analysisAdd BLAST31
Compositional biasi1622 – 1651PolarSequence analysisAdd BLAST30
Compositional biasi1660 – 1685PolarSequence analysisAdd BLAST26
Compositional biasi1693 – 1740PolarSequence analysisAdd BLAST48
Compositional biasi1876 – 1892PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1996 – 2014PolyampholyteSequence analysisAdd BLAST19
Compositional biasi2329 – 2370PolyampholyteSequence analysisAdd BLAST42
Compositional biasi2473 – 2490PolyampholyteSequence analysisAdd BLAST18

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1177 – 1245UBR-typePROSITE-ProRule annotationAdd BLAST69

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156357

Database of Orthologous Groups

More...
OrthoDBi
717at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14423, CUE_UBR5, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024725, E3_UbLigase_EDD_UBA
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR036053, PABP-dom
IPR002004, PABP_HYD
IPR009091, RCC1/BLIP-II
IPR003126, Znf_UBR

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11547, E3_UbLigase_EDD, 1 hit
PF00632, HECT, 1 hit
PF00658, PABP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00119, HECTc, 1 hit
SM00517, PolyA, 1 hit
SM00396, ZnF_UBR1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50985, SSF50985, 1 hit
SSF56204, SSF56204, 1 hit
SSF63570, SSF63570, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50237, HECT, 1 hit
PS51309, PABC, 1 hit
PS51157, ZF_UBR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A2I3BQS6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSIHFVVHP LPGTEDQLND RLREVSEKLN KYNLNSHPPL NVLEQATIKQ
60 70 80 90 100
CVVGPNHAAF LLEDGRICRI GFSVQPDRLE LGKPDNNDGS KLNSSSGTGR
110 120 130 140 150
TSRPGRTSDS PWFLSGSETL GRLAGNTLGS RWSSGVGGSG GGSSGRSSAG
160 170 180 190 200
ARDSRRQTRV IRTGRDRGSG LLGSQPQPVI PASVIPEELI SQAQVVLQGK
210 220 230 240 250
SRSVIIRELQ RTNLDVNLAV NNLLSRDDED GDDGDDTASE SYLPGEDLMS
260 270 280 290 300
LLDADIHSAH PSVIIDADAM FSEDISYFGY PSFRRSSLSR LGSSRVLLLP
310 320 330 340 350
LERDSELLRE RESVLRLRER RWLDGASFDN ERGSTSKEGE SNPDKKNTPV
360 370 380 390 400
QSPVSLGEDL QWWPDKDGTK FTCIGALYSE LLAVSSKGEL YQWKWSESEP
410 420 430 440 450
YRNAQNPSLH HPRATFLGLT NEKIVLLSAN SIRATVATEN NKVATWVDET
460 470 480 490 500
LSSVASKLEH TAQTYSELQG ERIVSLHCCA LYTCAQLENN LYWWGVVPFS
510 520 530 540 550
QRKKMLEKAR AKNKKPKSSA GISSMPNITV GTQVCLRNNP LYHAGAVAFS
560 570 580 590 600
ISAGIPKVGV LMESVWNMND SCRFQLRSPE SLKSMEKASK TLETKPESKQ
610 620 630 640 650
EPVKTEMGPP PSPASTCSDA SSIASSASMP YKRRRSTPAP REEEKVNEEQ
660 670 680 690 700
WPLREVVFVE DVKNVPVGKV LKVDGAYVAV KFPGTSTNTT CQNSSGPDAD
710 720 730 740 750
PSSLLQDCRL LRIDELQVVK TGGTPKVPDC FQRTPKKLCI PEKTEILAVN
760 770 780 790 800
VDSKGVHAVL KTGSWVRYCV FDLATGKAEQ ENNFPTSSVA FLGQDERSVA
810 820 830 840 850
IFTAGQESPI VLRDGNGTIY PMAKDCMGGI RDPDWLDLPP ISSLGMGVHS
860 870 880 890 900
LINLPANSTI KKKAAIIIMA VEKQTLMQHI LRCDYEACRQ YLVNLEQAVV
910 920 930 940 950
LEQNLQMLQT FISHRCDGNR NILHACVSVC FPTSNKETKE EEEAERSERN
960 970 980 990 1000
TFAERLSAVE AIANAISVVS SNGPGNRAGS SNSRSLRLRE MMRRSLRAAG
1010 1020 1030 1040 1050
LGRHEAGASS SDHQDPVSPP IAPPSWVPDP PSMDPDGDID FILAPAVGSL
1060 1070 1080 1090 1100
TTAATGSGQG PSTSTIPGPS TEPSVVESKD RKANAHFILK LLCDSAVLQP
1110 1120 1130 1140 1150
YLRELLSAKD ARGMTPFMSA VSGRAYPAAI TILETAQKIA KAEVSASEKE
1160 1170 1180 1190 1200
EDVFMGMVCP SGTNPDDSPL YVLCCNDTCS FTWTGAEHIN QDIFECRTCG
1210 1220 1230 1240 1250
LLESLCCCTE CARVCHKGHD CKLKRTSPTA YCDCWEKCKC KTLIAGQKSA
1260 1270 1280 1290 1300
RLDLLYRLLT ATNLVTLPNS RGEHLLLFLV QTVARQTVEH CQYRPPRIRE
1310 1320 1330 1340 1350
DRNRKTASPE DSDMPDHDLE PPRFAQLALE RVLQDWNALR SMIMFGSQEN
1360 1370 1380 1390 1400
KDPLSASSRI GHLLPEEQVY LNQQSGTIRL DCFTHCLIVK CTADILLLDT
1410 1420 1430 1440 1450
LLGTLVKELQ NKYTPGRREE AIAVTMRFLR SVARVFVILS VEMASSKKKN
1460 1470 1480 1490 1500
NFIPQPIGKC KRVFQALLPY AVEELCNVAE SLIVPVRMGI ARPTAPFTLA
1510 1520 1530 1540 1550
STSIDAMQGS EELFSVEPLP PRPSSDQASS SSQSQSSYII RNPQQRRISQ
1560 1570 1580 1590 1600
SQPVRGRDEE QDDIVSADVE EVEVVEGVAG EEDHHDEQEE HGEENAEAEG
1610 1620 1630 1640 1650
HHDEHDEDGS DMELDLLAAA ETESDSESNH SNQDNASGRR SVVTAATAGS
1660 1670 1680 1690 1700
EAGASSVPAF FSEDDSQSND SSDSDSSSSQ SDDIEQETFM LDEPLERTTN
1710 1720 1730 1740 1750
SSHANGAAQA PRSMQWAVRN PQHQRAASTA PSSTSTPAAS SAGLIYIDPS
1760 1770 1780 1790 1800
NLRRSGTIST SAAAAAAALE ASNASSYLTS ASSLARAYSI VIRQISDLMG
1810 1820 1830 1840 1850
LIPKYNHLVY SQIPAAVKLT YQDAVNLQNY VEEKLIPTWN WMVSVMDSTE
1860 1870 1880 1890 1900
AQLRYGSALA SAGDPGHPNH PLHASQNSAR RERMTAREEA SLRTLEGRRR
1910 1920 1930 1940 1950
ATLLSARQGM MSARGDFLNY ALSLMRSHND EHSDVLPVLD VCSLKHVAYV
1960 1970 1980 1990 2000
FQALIYWIKA MNQQTTLDTP QLERKRTREL LELGIDNEDS EHENDDDTSQ
2010 2020 2030 2040 2050
SATLNDKDDD SLPAETGQNH PFFRRSDSMT FLGCIPPNPF EVPLAEAIPL
2060 2070 2080 2090 2100
ADQPHLLQPN ARKEDLFGRP SQGLYSSSAG SGKCIVEVTM DRNCLEVLPT
2110 2120 2130 2140 2150
KMSYAANLKN VMNMQNRQKK EGEEQSLLAE EADSSKPGPS APDVAAQLKS
2160 2170 2180 2190 2200
SLLAEIGLTE SEGPPLTSFR PQCSFMGMVI SHDMLLGRWR LSLELFGRVF
2210 2220 2230 2240 2250
MEDVGAEPGS ILTELGGFEV KESKFRREME KLRNQQSRDL SLEVDRDRDL
2260 2270 2280 2290 2300
LIQQTMRQLN NHFGRRCATT PMAVHRVKVT FKDEPGEGSG VARSFYTAIA
2310 2320 2330 2340 2350
QAFLSNEKLP NLDCIQNANK GTHTSLMQRL RNRGERDRER EREREMRRSS
2360 2370 2380 2390 2400
GLRAGSRRDR DRDFRRQLSI DTRPFRPASE GNPSDDPDPL PAHRQALGER
2410 2420 2430 2440 2450
LYPRVQAMQP AFASKITGML LELSPAQLLL LLASEDSLRA RVDEAMELII
2460 2470 2480 2490 2500
AHGRENGADS ILDLGLLDSS EKVQENRKRH GSSRSVVDMD LEDTDDGDDN
2510 2520 2530 2540 2550
APLFYQPGKR GFYTPRPGKN TEARLNCFRN IGRILGLCLL QNELCPITLN
2560 2570 2580 2590 2600
RHVIKVLLGR KVNWHDFAFF DPVMYESLRQ LILASQSSDA DAVFSAMDLA
2610 2620 2630 2640 2650
FAIDLCKEEG GGQVELIPNG VNIPVTPQNV YEYVRKYAEH RMLVVAEQPL
2660 2670 2680 2690 2700
HAMRKGLLDV LPKNSLEDLT AEDFRLLVNG CGEVNVQMLI SFTSFNDESG
2710 2720 2730 2740 2750
ENAEKLLQFK RWFWSIVEKM SMTERQDLVY FWTSSPSLPA SEEGFQPMPS
2760 2770 2780 2790
ITIRPPDDQH LPTANTCISR LYVPLYSSKQ ILKQKLLLAI KTKNFGFV
Length:2,798
Mass (Da):308,968
Last modified:February 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB84A8F4AABB9C14
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q80TP3UBR5_MOUSE
E3 ubiquitin-protein ligase UBR5
Ubr5 Edd, Edd1, Kiaa0896
2,792Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q2H1E9Q2H1_MOUSE
E3 ubiquitin-protein ligase UBR5
Ubr5
2,792Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BPG8A0A2I3BPG8_MOUSE
E3 ubiquitin-protein ligase UBR5
Ubr5
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BQC1A0A2I3BQC1_MOUSE
E3 ubiquitin-protein ligase UBR5
Ubr5
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC122035 Genomic DNA No translation available.
AC122291 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001074828.2, NM_001081359.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000226414; ENSMUSP00000154293; ENSMUSG00000037487

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
70790

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122035 Genomic DNA No translation available.
AC122291 Genomic DNA No translation available.
RefSeqiNP_001074828.2, NM_001081359.3

3D structure databases

SMRiA0A2I3BQS6
ModBaseiSearch...

Proteomic databases

jPOSTiA0A2I3BQS6
MaxQBiA0A2I3BQS6

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
13236, 277 antibodies

Genome annotation databases

EnsembliENSMUST00000226414; ENSMUSP00000154293; ENSMUSG00000037487
GeneIDi70790

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51366
MGIiMGI:1918040, Ubr5

Phylogenomic databases

GeneTreeiENSGT00940000156357
OrthoDBi717at2759

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Ubr5, mouse

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

ExpressionAtlasiA0A2I3BQS6, baseline and differential

Family and domain databases

CDDicd14423, CUE_UBR5, 1 hit
InterProiView protein in InterPro
IPR024725, E3_UbLigase_EDD_UBA
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR036053, PABP-dom
IPR002004, PABP_HYD
IPR009091, RCC1/BLIP-II
IPR003126, Znf_UBR
PfamiView protein in Pfam
PF11547, E3_UbLigase_EDD, 1 hit
PF00632, HECT, 1 hit
PF00658, PABP, 1 hit
SMARTiView protein in SMART
SM00119, HECTc, 1 hit
SM00517, PolyA, 1 hit
SM00396, ZnF_UBR1, 1 hit
SUPFAMiSSF50985, SSF50985, 1 hit
SSF56204, SSF56204, 1 hit
SSF63570, SSF63570, 1 hit
PROSITEiView protein in PROSITE
PS50237, HECT, 1 hit
PS51309, PABC, 1 hit
PS51157, ZF_UBR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2I3BQS6_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2I3BQS6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: August 12, 2020
This is version 19 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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