Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 14 (22 Apr 2020)
Sequence version 1 (28 Feb 2018)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Leucine-rich repeat and guanylate kinase domain-containing protein

Gene

Lrguk

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Leucine-rich repeat and guanylate kinase domain-containing proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LrgukImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1921604, Lrguk

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A2I3BQA5, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini414 – 597Guanylate kinase-likeInterPro annotationAdd BLAST184

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni72 – 96DisorderedSequence analysisAdd BLAST25
Regioni611 – 632DisorderedSequence analysisAdd BLAST22
Regioni655 – 1340DisorderedSequence analysisAdd BLAST686

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi79 – 96AcidicSequence analysisAdd BLAST18
Compositional biasi655 – 673PolarSequence analysisAdd BLAST19
Compositional biasi684 – 699PolarSequence analysisAdd BLAST16
Compositional biasi752 – 792Pro-richSequence analysisAdd BLAST41
Compositional biasi824 – 849PolarSequence analysisAdd BLAST26
Compositional biasi850 – 877PolyampholyteSequence analysisAdd BLAST28
Compositional biasi914 – 933PolarSequence analysisAdd BLAST20
Compositional biasi940 – 959PolarSequence analysisAdd BLAST20
Compositional biasi971 – 985Pro-richSequence analysisAdd BLAST15
Compositional biasi1009 – 1037PolarSequence analysisAdd BLAST29
Compositional biasi1053 – 1068PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1108 – 1125PolarSequence analysisAdd BLAST18
Compositional biasi1126 – 1140PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1173 – 1194PolarSequence analysisAdd BLAST22
Compositional biasi1233 – 1253PolyampholyteSequence analysisAdd BLAST21
Compositional biasi1266 – 1280PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1290 – 1304PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1309 – 1340PolarSequence analysisAdd BLAST32

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157992

Identification of Orthologs from Complete Genome Data

More...
OMAi
INISMLP

Database of Orthologous Groups

More...
OrthoDBi
156510at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008145, GK/Ca_channel_bsu
IPR008144, Guanylate_kin-like_dom
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00625, Guanylate_kin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00072, GuKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50052, GUANYLATE_KINASE_2, 1 hit
PS51450, LRR, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A2I3BQA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAFERNPSR WKGTRFRRGL GASRIAAQAI LSLTEKQSQG RWPSFPLGLK
60 70 80 90 100
SKGTFRSASS YLLHQLIHRS HEAEAEQEEK QQEDGESEES EESEMQNLED
110 120 130 140 150
KYDGILREET VAEAITGLGW SGRGTEQVYL NLNLSHCELV DISILCGYVH
160 170 180 190 200
LQKLNLSGNR IEDLSCVSCM PYLLELNASQ NKLTTFFNFK PPQNLKKVDF
210 220 230 240 250
SSNLISEMYD LSAYHTLTQL ILDNNEIEEI TGLENCISLT HLSLAGNKIT
260 270 280 290 300
TIKGLGTLPI KVLSLSNNMI ETITGLEELK ALQNLDLSHN QISSLQGLEN
310 320 330 340 350
HDLLEVINLE DNKIKELSEI EYIENLPILR VLNLLRNPIQ TKPEYWFFVI
360 370 380 390 400
YMLLRLTELD QQKIKVEEKV FAVNKYDPPP EVVAVQDHMT HVVNSMSQPQ
410 420 430 440 450
RIWDSTLPSL DAPYPMLILT GPAACGKREL AHRLCRQFST YFRYGACHTT
460 470 480 490 500
RPPYFGEGDR VDYHFISQEV FDEMLNMGKF ILTFNYGNHN YGLNRDTIEG
510 520 530 540 550
IARDGLASCI HMELEGVRSL KYSYFEPRYI LVVPMDKEKY EGYLRRKGLF
560 570 580 590 600
SRAEIEIAVS RVDLYVKVNQ KYPGYFDAVI NADDMDIAYQ KLSELIREYL
610 620 630 640 650
GLTETAAKTL APTAGAPSSK KTASGVPAHL VPSPRRLARL QADGQKTEAF
660 670 680 690 700
LEVQTQAVVP ENQDPTLPQS QELTEEGEPP EKETNVPQQV SSSALGIPQQ
710 720 730 740 750
AQDLPPKVKE EDGQPANLPP KITTEMDGPE DEPGPPVPKA DQSSTLASQE
760 770 780 790 800
PPQQPAPAPT LSPQPAPAPT LSPQPAPAPT LSPQPAPAPT LSPQPDQDKE
810 820 830 840 850
SGETKVAPSN PALSEPAQGA DLASLSPQRV QDEGTESANP APRSSTHTLP
860 870 880 890 900
EDPSHTEVEK PTGGSQRPLK EETPKAEVMR AGTPYPEIPP PQDSTTKVRE
910 920 930 940 950
QPGALLPRSR LAPTRLPQPQ TLAPLQSRRP TPKLLSPSRE EALGTSSDQT
960 970 980 990 1000
PNPSPRSFPA QDGDPSKLPP ISPSQSKPPR NSSPPTAHSP QQGQVGKASE
1010 1020 1030 1040 1050
VKLPLISPPV QEQAQQHTPN PPQEEEAPTV QLPTIPAPST EPQLPQNTEP
1060 1070 1080 1090 1100
RPASKPAREK KTPKVGRASS KKVLDLQATP HSQGPTKQKG AKKKNLMQKE
1110 1120 1130 1140 1150
TAKESPQQRK MPVGNSQTAP QLESHDKPTP RNESDPLDFR SSPSHTEPVP
1160 1170 1180 1190 1200
ADPQNQEKNH KAHKPRKKAQ TNPTPKDVAQ STHTSPNGEM SEGLPQGNET
1210 1220 1230 1240 1250
ALGEDQPTRE GQPPQDPAKS AQEGSAPVLH PGEREQAQKR EKSQKREVAG
1260 1270 1280 1290 1300
KPEGEEIAAP SQLRVKETQA HRDTRENRQS YAQRHSILVS KQQSKEKRTR
1310 1320 1330 1340
KNGGVAQDRS PAAPQNQVSE EDQGSRTGRL RARGSQSIKV
Length:1,340
Mass (Da):147,896
Last modified:February 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB0801BC010AE99E4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9D5S7LRGUK_MOUSE
Leucine-rich repeat and guanylate k...
Lrguk
820Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8BR18Q8BR18_MOUSE
Leucine-rich repeat and guanylate k...
Lrguk
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Z1G4F6Z1G4_MOUSE
Leucine-rich repeat and guanylate k...
Lrguk
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC153817 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_006506777.1, XM_006506714.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000228187; ENSMUSP00000153993; ENSMUSG00000056215

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
74354

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC153817 Genomic DNA No translation available.
RefSeqiXP_006506777.1, XM_006506714.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
18051, 64 antibodies

Genome annotation databases

EnsembliENSMUST00000228187; ENSMUSP00000153993; ENSMUSG00000056215
GeneIDi74354

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
136332
MGIiMGI:1921604, Lrguk

Phylogenomic databases

GeneTreeiENSGT00940000157992
OMAiINISMLP
OrthoDBi156510at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Lrguk, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

ExpressionAtlasiA0A2I3BQA5, baseline and differential

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR008145, GK/Ca_channel_bsu
IPR008144, Guanylate_kin-like_dom
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00625, Guanylate_kin, 1 hit
SMARTiView protein in SMART
SM00072, GuKc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50052, GUANYLATE_KINASE_2, 1 hit
PS51450, LRR, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2I3BQA5_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2I3BQA5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: April 22, 2020
This is version 14 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again