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Entry version 15 (02 Jun 2021)
Sequence version 1 (28 Feb 2018)
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Protein
Submitted name:

Treacle ribosome biogenesis factor 1

Gene

TCOF1

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Treacle ribosome biogenesis factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TCOF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGorilla gorilla gorilla (Western lowland gorilla)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9595 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001519 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini216 – 291TreacleInterPro annotationAdd BLAST76
Domaini280 – 390TreacleInterPro annotationAdd BLAST111
Domaini387 – 843TreacleInterPro annotationAdd BLAST457
Domaini825 – 971TreacleInterPro annotationAdd BLAST147

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni19 – 1249DisorderedSequence analysisAdd BLAST1231
Regioni1283 – 1448DisorderedSequence analysisAdd BLAST166

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi21 – 38Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi66 – 80Polar residuesSequence analysisAdd BLAST15
Compositional biasi104 – 138Polar residuesSequence analysisAdd BLAST35
Compositional biasi604 – 618Polar residuesSequence analysisAdd BLAST15
Compositional biasi737 – 751Polar residuesSequence analysisAdd BLAST15
Compositional biasi789 – 804Polar residuesSequence analysisAdd BLAST16
Compositional biasi937 – 957Polar residuesSequence analysisAdd BLAST21
Compositional biasi1014 – 1031Polar residuesSequence analysisAdd BLAST18
Compositional biasi1049 – 1083Polar residuesSequence analysisAdd BLAST35
Compositional biasi1131 – 1145Polar residuesSequence analysisAdd BLAST15
Compositional biasi1154 – 1196Polar residuesSequence analysisAdd BLAST43
Compositional biasi1283 – 1314Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi1346 – 1387Basic and acidic residuesSequence analysisAdd BLAST42
Compositional biasi1402 – 1423Basic residuesSequence analysisAdd BLAST22
Compositional biasi1424 – 1448Basic and acidic residuesSequence analysisAdd BLAST25

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111382

Identification of Orthologs from Complete Genome Data

More...
OMAi
DFPECDP

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017859, Treacle
IPR003993, Treacle_dom

The PANTHER Classification System

More...
PANTHERi
PTHR20787, PTHR20787, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03546, Treacle, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A2I2Z3S8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
KCFLAQPVTL LDIYTHWQQT SELGRKRKAE EDAALQAKKT RVSDPISTSE
60 70 80 90 100
SSEEEEEAEA ETAKATPRLA STNSSVLGAD LPSSMKEKAK AETEKAGKTG
110 120 130 140 150
NSMPHPATGK TVANLLSGKS PRKSAEPSAN TTLVSETEEE GSVPAFGAAA
160 170 180 190 200
KPGMVSAGQA DSSSEDTSSS SDETDVEGKP SVKPAQVKAS SVSTKESPAR
210 220 230 240 250
KAAPAPGKVG DVTPQVKGGA LPPAKRAKKP EEESESSEEG SESEEEAPAG
260 270 280 290 300
TRSQVKASEK ILQVRAASAP AKGTPGKGAT PAPPGKAGAV ASQTKAGKPE
310 320 330 340 350
EDSESSSEES SDSEEETPAA KALLQAKASG KTSQVGAASA PAKESPRKGA
360 370 380 390 400
APAPPGKTGP AVAKAQAGKR EEDSQSSSEE SDSEEEAPAQ AKPSGKAPQV
410 420 430 440 450
RAASAPAKES PRKGAAPAPP RKTGPAAAQV QVGKQEEDSG SSSEESDSDR
460 470 480 490 500
EALAAMNAVQ VKPLGKSPQV KPASTMGMGP LGKGAGPVPP GKVGPATPSA
510 520 530 540 550
QVGKWEEDSE SSSEESSDSS DGEVPTAVAP AQEKSLGNIL QAKPASSPAK
560 570 580 590 600
GPPQKAGPVA VQVKAEKPMD NSESSEESSD SAEAPAAMTA AQAKPALKIP
610 620 630 640 650
QTKACPKRTN TTASAKVAPV RVGTQAPRKA GTATSPAGSS PAVAGGAQRP
660 670 680 690 700
AEDSSSSEES DSEEEKTGLA VTVGQVKSVG KGLQVKAASV PVKGSLGQGT
710 720 730 740 750
APVLPGKTGP TVTQVKAEKQ EDSESSEEES DSEEAAASPA QVKTSVKKTQ
760 770 780 790 800
AKANPAAARA PSAKGTISAP GKVVTAAAQA KQRSPSKVKP PVRNPQNSTV
810 820 830 840 850
LARGPASVPS VGKAVATAAQ AQTGPEEDSG SSEEESDSEE EAETLAQAKP
860 870 880 890 900
SGKTPQIRAA LAPAKESPRK GAAPTPPGKT GPSAAQAGKQ DDSGSSSEES
910 920 930 940 950
DSDGEAPAAV TSAQVIKPPL IFVDPNRSPA GPAATPAQAQ AASTPRKARA
960 970 980 990 1000
SESTARSSSS ESEDEDMIPA TQCLTPGIRT NVVTMPTAHP RIAPKASMAG
1010 1020 1030 1040 1050
ASSSKESSRI SDGKKQEGPA TQVSKKNPAS LPLTQAALKV LAQKASEAQP
1060 1070 1080 1090 1100
PVARTQPSSG VDSAVGTLPA TSPQSTSIQA KGTNKLRKPK LPEVQQATKA
1110 1120 1130 1140 1150
PESSDDSEDS SDSSSGSEED AEGPQGAKSA HTLGPTPSRT ETLVEETAAE
1160 1170 1180 1190 1200
SSEDDVVAPS QSLLSGYMTP GLTPANSQAS KATPKLDSSP SVSSTLAAKD
1210 1220 1230 1240 1250
DPDGKQEAKP QQAAGMLSPK TGGKEAASGT TPQKSRKPKK GAGNPQASTL
1260 1270 1280 1290 1300
ALQSNITQCL LGQPWPLNEA QVQASVVKVL TELLEQERKK VVDTTKESSR
1310 1320 1330 1340 1350
KGWESRKRKL SGDQPAARTP RSKKKKKLGA GEGGEASVSP EKTSTTSKGK
1360 1370 1380 1390 1400
AKRDKASGDV KEKKGKGSLG SQGAKDEPEE ELQKGMGKVE GGDQSNPKSK
1410 1420 1430 1440
KEKKKSDKRK KDKEKKEKKK KAKKASTKDS ESPSQKKKKK KKTAEQTV
Length:1,448
Mass (Da):147,362
Last modified:February 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6E8CE209166819B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3RM90G3RM90_GORGO
Treacle ribosome biogenesis factor ...
TCOF1
1,448Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3R7R8G3R7R8_GORGO
Treacle ribosome biogenesis factor ...
TCOF1
1,372Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I2Z714A0A2I2Z714_GORGO
Treacle ribosome biogenesis factor ...
TCOF1
1,440Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I2Y3G0A0A2I2Y3G0_GORGO
Treacle ribosome biogenesis factor ...
TCOF1
919Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CABD030041683 Genomic DNA No translation available.
CABD030041684 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGGOT00000045697; ENSGGOP00000041929; ENSGGOG00000011690

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABD030041683 Genomic DNA No translation available.
CABD030041684 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSGGOT00000045697; ENSGGOP00000041929; ENSGGOG00000011690

Phylogenomic databases

GeneTreeiENSGT00730000111382
OMAiDFPECDP

Family and domain databases

InterProiView protein in InterPro
IPR017859, Treacle
IPR003993, Treacle_dom
PANTHERiPTHR20787, PTHR20787, 2 hits
PfamiView protein in Pfam
PF03546, Treacle, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2I2Z3S8_GORGO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2I2Z3S8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: June 2, 2021
This is version 15 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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