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Protein

Claudin

Gene
N/A
Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
ClaudinUniRule annotation
OrganismiGorilla gorilla gorilla (Western lowland gorilla)Imported
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi
  • UP000001519 Componenti: Chromosome 16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei79 – 105HelicalUniRule annotationAdd BLAST27
Transmembranei117 – 144HelicalUniRule annotationAdd BLAST28
Transmembranei164 – 183HelicalUniRule annotationAdd BLAST20

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotationSAAS annotation, Membrane, Tight junctionUniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118928
KOiK06087
OMAiCPPPQID

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003553 Claudin9
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF42 PTHR12002:SF42, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01382 CLAUDIN9
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2I2Z2C4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASTGLELLG MTLAVLGWLG TLVSCALPLW KVTAFIGNSI VVAQVVWEGL
60 70 80 90 100
WMSCVVQSTG QMQCKVYDSL LALPQDLQAA RALCVIALLL ALLGLLVAIT
110 120 130 140 150
GAQCTTCVED EGAKARIVLT AGVILLLAGI LVLIPVCWTA HAIIQDFYNP
160 170 180 190 200
LVAEALKREL GASLYLGWAA AALLMLGGGL LCCTCPPPQV ERPHGPRLGY
210
SIPSRSGASG LDKRDYV
Length:217
Mass (Da):22,829
Last modified:February 28, 2018 - v1
Checksum:iAFF3C5B5CB3AAC8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABD030098510 Genomic DNA No translation available.
RefSeqiXP_004057095.1, XM_004057047.2

Genome annotation databases

EnsembliENSGGOT00000058756; ENSGGOP00000041130; ENSGGOG00000041931
GeneIDi101126032
KEGGiggo:101126032

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABD030098510 Genomic DNA No translation available.
RefSeqiXP_004057095.1, XM_004057047.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGGOT00000058756; ENSGGOP00000041130; ENSGGOG00000041931
GeneIDi101126032
KEGGiggo:101126032

Organism-specific databases

CTDi9080

Phylogenomic databases

GeneTreeiENSGT00760000118928
KOiK06087
OMAiCPPPQID

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003553 Claudin9
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF42 PTHR12002:SF42, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01382 CLAUDIN9
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2I2Z2C4_GORGO
AccessioniPrimary (citable) accession number: A0A2I2Z2C4
Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: November 7, 2018
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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