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Protein
Submitted name:

Protein tyrosine phosphatase, receptor type O

Gene

PTPRO

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1108Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protein tyrosine phosphatase, receptor type OImported
Gene namesi
Name:PTPROImported
OrganismiGorilla gorilla gorilla (Western lowland gorilla)Imported
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi
  • UP000001519 Componenti: Chromosome 12

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei820 – 844HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_501415887630 – 1188Sequence analysisAdd BLAST1159

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini329 – 425Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini435 – 531Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini532 – 628Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini631 – 724Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini725 – 817Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini910 – 1167Tyrosine-protein phosphataseInterPro annotationAdd BLAST258
Domaini1084 – 1158TYR_PHOSPHATASE_2InterPro annotationAdd BLAST75

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00900000140785

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 3 hits
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
SSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 5 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2I2YLW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHLPTGIHG ARRLLPLLWL FVLFKNATAF HVTVQDDNNI VVSLEASDVI
60 70 80 90 100
SPASVYVVKI TGESKNYFFE FEEFNSTLPP PVIFKASYHG LYYIITLVVV
110 120 130 140 150
NGNVVTKPSR SITVLTKPLP VTSVSIYDYK PSPETGVLFE IHYPEKYNVF
160 170 180 190 200
TRVNISYWEG KDFRTMLYKD FFKGKTVFNH WLPGMCYSNI TFQLVSEATF
210 220 230 240 250
NKSTLVEYSG VSHEPKQHRT APYPPQNISV RIVNLNKNNW EEQSGNFPEE
260 270 280 290 300
SFMRSQDTIG KEKLFHFTEE IPEIPSGNIS SGWPDFNSSD YETTSQPYWW
310 320 330 340 350
DSASAAPESE DEFVSVLPME YENNSTLSET EKSTSGSFSF FPVQMILTWL
360 370 380 390 400
PPKPPTAFDG FHIHIEREEN FTEYLMVDEE AHEFVAELKE PGKYKLSVTT
410 420 430 440 450
FSSSGSCETR KSQSAKSLSF YISPSGEWIE ELTEKPQHVS VHVLSSTTAL
460 470 480 490 500
MSWTSSQENY NSTIVSVVSL TCQKQKESQR LEKQYCTQVN SSKPIIENLV
510 520 530 540 550
PGAQYQVVIY LRKGPLIGPP SDPVTFAIVP TGIKDLMLYP LGPTAVVLSW
560 570 580 590 600
TRPYLGVFRK YVVEMFYFNP ATMTSEWTTY YEIAATVSLT ASVRIANLLP
610 620 630 640 650
AWYYNFRVTM VTWGDPELSC CDSSTISFIT APVAPEITSV EYFNSLLYIS
660 670 680 690 700
WTYGDDTTDL SHSRMLHWMV VAEGKKKIKK SVTRNVMTAI LSLPPGDIYN
710 720 730 740 750
LSVTACTERG SNTSMLRLVK LEPAPPKSLF AVNKTQTSVT LLWVEEGVAD
760 770 780 790 800
FFEVFCQQVG SSQKTKLQEP VAVSSHVVTI SSLLPATAYN CSVTSFSHDS
810 820 830 840 850
PSVPTFIAVS TMVTEMNPNV VVISVLAILS TLLIGLLLVT LIILRKKHLQ
860 870 880 890 900
MARECGAGTF VNFASLERDG KLPYNWSKNG LKKRKLTNPV QLDDFDAYIK
910 920 930 940 950
DMAKDSDYKF SLQFEELKLI GLDIPHFAAD LPLNRCKNRY TNILPYDFSR
960 970 980 990 1000
VRLVSMNEEE GADYINANYI PGYNSPQEYI ATQGPLPETR NDFWKMVLQQ
1010 1020 1030 1040 1050
KSQIIVMLTQ CNEKRRVKCD HYWPFTEEPI AYGDITVEMI SEEEQDDWAC
1060 1070 1080 1090 1100
RHFRINYADE MQDVMHFNYT AWPDHGVPTA NAAESILQFV HMVRQQATKS
1110 1120 1130 1140 1150
KSPMIIHCSA GVGRTGTFIA LDRLLQHIRD HEFVDILGLV SEMRSYRMSM
1160 1170 1180
VQTEEQYIFI HQCVQLMWMK KKQQFCISDV IYENVSKS
Length:1,188
Mass (Da):134,983
Last modified:February 28, 2018 - v1
Checksum:iA023DFFE629379D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABD030083010 Genomic DNA No translation available.
CABD030083011 Genomic DNA No translation available.
RefSeqiXP_018893972.1, XM_019038427.1

Genome annotation databases

EnsembliENSGGOT00000068024; ENSGGOP00000035885; ENSGGOG00000014998
GeneIDi101139138

Similar proteinsi

Entry informationi

Entry nameiA0A2I2YLW3_GORGO
AccessioniPrimary (citable) accession number: A0A2I2YLW3
Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: May 23, 2018
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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