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Protein

Dihydropyrimidine dehydrogenase [NADP(+)]

Gene

DPYD

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.UniRule annotation

Catalytic activityi

5,6-dihydrouracil + NADP+ = uracil + NADPH.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • FADUniRule annotation
  • FMNUniRule annotation
  • [4Fe-4S] clusterUniRule annotationNote: Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.UniRule annotation

Pathwayi: beta-alanine biosynthesis

This protein is involved in the pathway beta-alanine biosynthesis, which is part of Amino-acid biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway beta-alanine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Ligand4Fe-4SUniRule annotation, FADUniRule annotation, Flavoprotein, FMNUniRule annotation, Iron, Iron-sulfur, Metal-binding, NADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00131

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropyrimidine dehydrogenase [NADP(+)]UniRule annotation (EC:1.3.1.2UniRule annotation)
Short name:
DHPDHaseUniRule annotation
Short name:
DPDUniRule annotation
Alternative name(s):
Dihydrothymine dehydrogenaseUniRule annotation
Dihydrouracil dehydrogenaseUniRule annotation
Gene namesi
Name:DPYDImported
OrganismiFelis catus (Cat) (Felis silvestris catus)Imported
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Chromosome C1

Subcellular locationi

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 1004Fe-4S ferredoxin-typeInterPro annotationAdd BLAST32
Domaini944 – 9764Fe-4S ferredoxin-typeInterPro annotationAdd BLAST33
Domaini978 – 10074Fe-4S ferredoxin-typeInterPro annotationAdd BLAST30

Sequence similaritiesi

Belongs to the dihydropyrimidine dehydrogenase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00500000044896
KOiK00207

Family and domain databases

Gene3Di1.10.1060.10, 1 hit
3.20.20.70, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR013785 Aldolase_TIM
IPR005720 Dihydroorotate_DH
IPR028261 DPD_II
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR009051 Helical_ferredxn
PfamiView protein in Pfam
PF01180 DHO_dh, 1 hit
PF14691 Fer4_20, 1 hit
PF07992 Pyr_redox_2, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
TIGRFAMsiTIGR01037 pyrD_sub1_fam, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 3 hits

Sequencei

Sequence statusi: Complete.

A0A2I2UPM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVLSKDSA DIESILALNP RTQTHAALRS TSAKKVDKKH WKRNTDKNCS
60 70 80 90 100
KCEKLENNFD DIKHTTLGER GALREAMRCL KCADAPCQKS CPTNLDIKSF
110 120 130 140 150
ITSIANKNYY GAAKMIFSDN PLGLTCGMVC PTSDLCVGGC NLYATEEGPI
160 170 180 190 200
NIGGLQQFAT EVFKTMNITQ IRDPSLPPPE KMPEAYSAKI ALFGAGPASI
210 220 230 240 250
SCASFLARLG YSDITIFEKQ EYVGGLSTSE IPQFRLPYDA VHFEIELMKD
260 270 280 290 300
LGVKIICGKS LSVDDMTLST LKEEGYKAAF IGIGLPDPNK NHIFKDLTQD
310 320 330 340 350
HGFYTSKDFL PLVAKSSKAG MCACHSPLPS IRGVVIVLGA GDTAFDCATS
360 370 380 390 400
ALCCGARRVF IVFRKGFVNI RAVPEEVELA KEKRCEFLPF LSPRKVIVKG
410 420 430 440 450
GRIVAMQFVR TEQDEMGNWN EHEDELVHLR ADVVISAFGS VLSDPTVKEA
460 470 480 490 500
LSPLKFNRWN LPEVDPETMQ TSEPWVFAGG DIVGVANTTV ESVNDGKQAS
510 520 530 540 550
WYIHKYIQSQ YGASVSAKPE VPLFYTPIDL VDISVEMAGL KFINPFGLAS
560 570 580 590 600
ATPATSTSMI RRAFEAGWGF ALTKTFSLDK DIVTNVSPRI IRGTTSGPMY
610 620 630 640 650
GPGQSSFLNI ELISEKTAAY WCQSVTELKA DFPDNIVIAS IMCSYSKNDW
660 670 680 690 700
MELSKMAEAS GADALELNLS CPHGMGERGM GLACGQDPEL VRNICRWVRQ
710 720 730 740 750
AVQIPFFAKL TPNVTDIVSI ARAAKEGGAD GVTATNTVSG LMGLKADGTP
760 770 780 790 800
WPAVGIGKRT TYGGVSGTAI RPIALRAVTS IARALPGFPI LATGGIDSAE
810 820 830 840 850
SGLQFLHSGA SVLQVCSAIQ NQDFTVIQDY CTGLKALLYL KSIEELQDWD
860 870 880 890 900
GQSPATMSHQ KGKPVPRIAE LMGKKLPSFG PYLERRKEII AENKIRQKEQ
910 920 930 940 950
NAAFPPLERK PFIPRKPIPT IKDVIGKALQ YLGTFGELSH LEQVVAMIDE
960 970 980 990 1000
EMCINCGKCY MTCNDSGYQA IQFDPETHLP TITDSCTGCT LCLSVCPIID
1010 1020
CIKMVSRTTP YEPKRGLPLA VNNLVC
Length:1,026
Mass (Da):111,725
Last modified:February 28, 2018 - v1
Checksum:iDD489F9CF6A74B85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AANG03348160 Genomic DNA No translation available.
AANG03348161 Genomic DNA No translation available.
AANG03348162 Genomic DNA No translation available.
AANG03348163 Genomic DNA No translation available.
AANG03348164 Genomic DNA No translation available.
AANG03348165 Genomic DNA No translation available.
AANG03348166 Genomic DNA No translation available.
AANG03348167 Genomic DNA No translation available.
AANG03348168 Genomic DNA No translation available.
AANG03348169 Genomic DNA No translation available.
RefSeqiXP_011283146.1, XM_011284844.2

Genome annotation databases

EnsembliENSFCAT00000036504; ENSFCAP00000034474; ENSFCAG00000039421
GeneIDi101084380
KEGGifca:101084380

Similar proteinsi

Entry informationi

Entry nameiA0A2I2UPM5_FELCA
AccessioniPrimary (citable) accession number: A0A2I2UPM5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: June 20, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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