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Protein

NADPH--cytochrome P450 reductase

Gene

cprA

Organism
Aspergillus steynii IBT 23096
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

NADPH + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • FADUniRule annotationNote: Binds 1 FAD per monomer.UniRule annotation
  • FMNUniRule annotationNote: Binds 1 FMN per monomer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei204FMNUniRule annotation1
Binding sitei296NADPUniRule annotation1
Binding sitei552NADPUniRule annotation1
Binding sitei656NADPUniRule annotation1
Binding sitei694FADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi72 – 77FMNUniRule annotation6
Nucleotide bindingi123 – 126FMNUniRule annotation4
Nucleotide bindingi169 – 178FMNUniRule annotation10
Nucleotide bindingi451 – 454FADUniRule annotation4
Nucleotide bindingi469 – 471FADUniRule annotation3
Nucleotide bindingi486 – 489FADUniRule annotation4
Nucleotide bindingi614 – 615NADPUniRule annotation2
Nucleotide bindingi620 – 624NADPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesisUniRule annotation, Sterol metabolism
LigandFADUniRule annotation, Flavoprotein, FMNUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH--cytochrome P450 reductaseUniRule annotation (EC:1.6.2.4UniRule annotation)
Short name:
CPRUniRule annotation
Short name:
P450RUniRule annotation
Gene namesi
Name:cprAUniRule annotation
ORF Names:P170DRAFT_440764Imported
OrganismiAspergillus steynii IBT 23096Imported
Taxonomic identifieri1392250 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000234275 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membraneUniRule annotation, Endoplasmic reticulumUniRule annotation, Membrane, Mitochondrion, Mitochondrion outer membraneUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 221Flavodoxin-likeInterPro annotationAdd BLAST156
Domaini277 – 538FAD-binding FR-typeInterPro annotationAdd BLAST262

Sequence similaritiesi

Belongs to the NADPH--cytochrome P450 reductase family.UniRule annotation
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.UniRule annotation
In the N-terminal section; belongs to the flavodoxin family.UniRule annotation

Family and domain databases

Gene3Di1.20.990.10, 1 hit
3.40.50.360, 1 hit
3.40.50.80, 1 hit
HAMAPiMF_03212 NCPR, 1 hit
InterProiView protein in InterPro
IPR003097 FAD-binding_1
IPR017927 Fd_Rdtase_FAD-bd
IPR001094 Flavdoxin-like
IPR008254 Flavodoxin/NO_synth
IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR029039 Flavoprotein-like_sf
IPR039261 FNR_nucleotide_bd
IPR023173 NADPH_Cyt_P450_Rdtase_alpha
IPR001433 OxRdtase_FAD/NAD-bd
IPR023208 P450R
IPR017938 Riboflavin_synthase-like_b-brl
PfamiView protein in Pfam
PF00667 FAD_binding_1, 1 hit
PF00258 Flavodoxin_1, 1 hit
PF00175 NAD_binding_1, 1 hit
PIRSFiPIRSF000208 P450R, 1 hit
PRINTSiPR00369 FLAVODOXIN
PR00371 FPNCR
SUPFAMiSSF52218 SSF52218, 1 hit
SSF52343 SSF52343, 1 hit
SSF63380 SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS51384 FAD_FR, 1 hit
PS50902 FLAVODOXIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2I2FV18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLDTLDLV VLVALLVGSV AYFTKGTYWA VAKDPYASTG PAMNGGAKAG
60 70 80 90 100
KTRDIIEKMD ETGKNCVIFY GSQTGTAEDY ASRLAKEGSQ RFGLKTMVAD
110 120 130 140 150
LEDYDYENLE KFPEDKVVFF VLATYGEGEP TDNAVEFYQF ATGEDAAFES
160 170 180 190 200
GATADDKPLS SLKYVTFGLG NNTYEHYNAM VRNVDSALQK FGAQRIGSAG
210 220 230 240 250
EGDDGAGTME EDFLAWKEPM WTALSEAMNL QERDAVYEPV FNVAEDESLS
260 270 280 290 300
PEDENVYLGE PTQGHLQGEP KGPYSAHNPF IAPISESREL FNVKDRNCLH
310 320 330 340 350
MEISIAGSNL TYQTGDHIAV WPTNAGAEVD RFLQAFGLEG KRHTVINVKG
360 370 380 390 400
IDVTAKVPIP TPTTYDAAVR YYLEVCAPVS RQFVSTLAAF APDEATKAEI
410 420 430 440 450
VRLGGDKDYF HEKITNRCFN IAQALQSITS KPFTAVPFSL LIEGLTKLQP
460 470 480 490 500
RYYSISSSSL VQKDKISITA VVESVRLPGE EHIVKGVTTN YLLALKEKQN
510 520 530 540 550
GEPAPDPHGL TYSITGPRNK YDGIHVPVHV RHSNFKLPSD PSRPVIMVGP
560 570 580 590 600
GTGVAPFRGF VQERAALAAK GEKVGPTVLF FGCRKSDEDF LYKDEWKTFQ
610 620 630 640 650
EQLGDSLKII TAFSRESAQK VYVQHRLSEH AELVSDLLKQ KATFYVCGDA
660 670 680 690
ANMAREVNLV LGQIIAKQRG LPAEKGEEMV KHMRSSGSYQ EDVWS
Length:695
Mass (Da):76,500
Last modified:February 28, 2018 - v1
Checksum:i166CE01E8FE6C291
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MSFO01000009 Genomic DNA Translation: PLB44489.1

Similar proteinsi

Entry informationi

Entry nameiA0A2I2FV18_9EURO
AccessioniPrimary (citable) accession number: A0A2I2FV18
Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: July 18, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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