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Protein

Poly [ADP-ribose] polymerase

Gene

PARP1

Organism
Columba livia (Rock dove)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase
LigandNADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymeraseUniRule annotation (EC:2.4.2.30UniRule annotation)
Short name:
PARPUniRule annotation
Gene namesi
Name:PARP1Imported
ORF Names:A306_00009798Imported
OrganismiColumba livia (Rock dove)Imported
Taxonomic identifieri8932 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeColumbiformesColumbidaeColumba
Proteomesi
  • UP000053872 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 49PARP-typeInterPro annotationAdd BLAST49
Domaini71 – 161PARP-typeInterPro annotationAdd BLAST91
Domaini340 – 416BRCTInterPro annotationAdd BLAST77
Domaini617 – 736PARP alpha-helicalInterPro annotationAdd BLAST120
Domaini745 – 971PARP catalyticInterPro annotationAdd BLAST227

Phylogenomic databases

KOiK10798

Family and domain databases

CDDicd00027 BRCT, 1 hit
Gene3Di1.20.142.10, 1 hit
2.20.140.10, 1 hit
2.20.25.630, 1 hit
3.30.1740.10, 2 hits
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR012982 PADR1
IPR038650 PADR1_dom_sf
IPR008288 PARP
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR004102 Poly(ADP-ribose)pol_reg_dom
IPR036616 Poly(ADP-ribose)pol_reg_dom_sf
IPR036930 WGR_dom_sf
IPR008893 WGR_domain
IPR001510 Znf_PARP
IPR036957 Znf_PARP_sf
PfamiView protein in Pfam
PF00533 BRCT, 1 hit
PF08063 PADR1, 1 hit
PF00644 PARP, 1 hit
PF02877 PARP_reg, 1 hit
PF05406 WGR, 1 hit
PF00645 zf-PARP, 2 hits
PIRSFiPIRSF000489 NAD_ADPRT, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 1 hit
SM01335 PADR1, 1 hit
SM00773 WGR, 1 hit
SM01336 zf-PARP, 2 hits
SUPFAMiSSF142921 SSF142921, 1 hit
SSF47587 SSF47587, 1 hit
SSF52113 SSF52113, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS51060 PARP_ALPHA_HD, 1 hit
PS51059 PARP_CATALYTIC, 1 hit
PS00347 PARP_ZN_FINGER_1, 1 hit
PS50064 PARP_ZN_FINGER_2, 2 hits

Sequencei

Sequence statusi: Complete.

A0A2I0M550-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDGKVPHWH HYSCFWKRAR ILSHADIDGF PELRWEDQEK IKKAIETGGP
60 70 80 90 100
GGGKGGEQEG GGKAEKSLND FAAEYAKSNR STCKGCEQKI EKGQIRISKK
110 120 130 140 150
MVHPEKPQLG MIDNWYHPDC FVSRRAELGF LPVYGATQLL GFSILKAEDK
160 170 180 190 200
ETLKKQLPAT KSEGKRKGEE VDGNVTVKKK PKKEKEKESK QEKQLKEQTQ
210 220 230 240 250
LIWSIKDELR KVCSTNDLKE LLIANKQEVP SGENAILDRV ADGMAFGALL
260 270 280 290 300
PCEECKGQFV FKSDAYYCSG DITAWTKCVA KTQTPNRKDW VIPKEFREIP
310 320 330 340 350
YLKKFKCKKQ DRVFPPDAGT GNSVPPPSAS APPTETVSAP RDKPLTNMKI
360 370 380 390 400
LVLGKLSKNK EEVKSIVEDL GGKMTTTANK ATLCISTQKD VEKMSKKMEE
410 420 430 440 450
VKAAKVRVVS EEFLQDVKSS SKDFQELVSL HALSPWGAEV KMEHEEMAVD
460 470 480 490 500
GKCSKPPSMK SAGKVKEEQG PSKSEKKMKL TVKGGAAVDP DSGLEDSAHV
510 520 530 540 550
FEKGGKIFSA TLGLVDIVKG TNSYYKLQLL EDDRENRYWV FRSWGRVGTV
560 570 580 590 600
IGSNKLEQMP SKEDAIEHFL NLYEEKTGNS WHSKNFTKYP KKFYPLEIDY
610 620 630 640 650
GQDEEAVKKL TVGAGTKSKL PKPIQDLIKM IFDVESMKKA MVEFEIDLQK
660 670 680 690 700
MPLGKLSKRQ IQSAYSXXXX XHERNAVSDN GSESQILDLS NRFYTLIPHD
710 720 730 740 750
FGMKKPPLLN NLEYIQAKVQ MLDNLLDIEV AYSLLRGGNE DGDKDPIDIN
760 770 780 790 800
YEKLKTDIKV VDKDSEEAKI IKQYVKNTHA ATHNAYDLKV VDIFRIEREG
810 820 830 840 850
ESQRYKPFKQ LHNRQLLWHG SRTTNFAGIL SQGLRIAPPE APVTGYMFGK
860 870 880 890 900
GIYFADMVSK SANYCHTSQA DPIGLVLLGE VALGNMYELK NASHITKLPK
910 920 930 940 950
GKHSVKGLGK TAPDPTATTT LGGVEVPLGN GISTGINDTC LLYNEYIVYD
960 970
VAQVNLKYLL KLKFNYKTSL W
Length:971
Mass (Da):108,841
Last modified:February 28, 2018 - v1
Checksum:i3F1EA895FCDD3B58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AKCR02000039 Genomic DNA Translation: PKK24804.1
RefSeqiXP_005507407.1, XM_005507350.1

Genome annotation databases

GeneIDi102086303
KEGGiclv:102086303

Similar proteinsi

Entry informationi

Entry nameiA0A2I0M550_COLLI
AccessioniPrimary (citable) accession number: A0A2I0M550
Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: June 20, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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