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Entry version 6 (16 Jan 2019)
Sequence version 1 (28 Feb 2018)
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Protein
Submitted name:

CDK5 regulatory subunit associated protein 2

Gene

CDK5RAP2

Organism
Columba livia (Rock dove)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CDK5 regulatory subunit associated protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDK5RAP2Imported
ORF Names:A306_00012353Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiColumba livia (Rock dove)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8932 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeColumbiformesColumbidaeColumba
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000053872 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 71Cnn_1NInterPro annotationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1 – 21Sequence analysisAdd BLAST21
Coiled coili44 – 71Sequence analysisAdd BLAST28
Coiled coili76 – 125Sequence analysisAdd BLAST50
Coiled coili163 – 183Sequence analysisAdd BLAST21
Coiled coili216 – 250Sequence analysisAdd BLAST35
Coiled coili258 – 292Sequence analysisAdd BLAST35
Coiled coili304 – 394Sequence analysisAdd BLAST91
Coiled coili403 – 472Sequence analysisAdd BLAST70
Coiled coili486 – 507Sequence analysisAdd BLAST22
Coiled coili524 – 544Sequence analysisAdd BLAST21
Coiled coili599 – 619Sequence analysisAdd BLAST21
Coiled coili798 – 818Sequence analysisAdd BLAST21
Coiled coili836 – 863Sequence analysisAdd BLAST28
Coiled coili1102 – 1122Sequence analysisAdd BLAST21
Coiled coili1196 – 1216Sequence analysisAdd BLAST21
Coiled coili1326 – 1346Sequence analysisAdd BLAST21
Coiled coili1402 – 1433Sequence analysisAdd BLAST32
Coiled coili1479 – 1520Sequence analysisAdd BLAST42
Coiled coili1535 – 1572Sequence analysisAdd BLAST38
Coiled coili1597 – 1635Sequence analysisAdd BLAST39
Coiled coili1825 – 1845Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K16542

Database of Orthologous Groups

More...
OrthoDBi
1046642at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012943 Cnn_1N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07989 Cnn_1N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2I0LWA8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDYENQITD LKKENFNLKL RIYFLEERMQ QKFDGPTEEI YKINIELKVE
60 70 80 90 100
IESLKRDLQE REKLLIKASK AVESLAQGGE AEIQRVKEEA QKKMQEMEKI
110 120 130 140 150
LTSRINLLEE NLKTAQEDVE KATAMTEKEK ALRTAAEQKL SSIMNAPAKD
160 170 180 190 200
VDTITGAEKD RLIEQLNLSL KSKEAQIQHL EEEKAQSGDG NLSAEKIREL
210 220 230 240 250
TIALRHEKDS EIEAIRMELR NERNSFEKKI QSLQEELQER ENELAVEKKN
260 270 280 290 300
GLKRDKTIQG LTVALKAKEK ENEELGSEIE DLNASLAKAR EATHKAHVQK
310 320 330 340 350
FKGAEDYQAL LMEKETLLAE LRSENLTKDA ENRKLQRRIK RTDQELSDLN
360 370 380 390 400
LEREKMEKEL DEAQLQKSRS DKTINDLRNQ LEKLHGEMSE KEKAVEHHYN
410 420 430 440 450
ILLSESNQKL QSQELVIKQL TDNANQKELL LQKLDGTVKE KDAELQELLN
460 470 480 490 500
KYKNLLRANE ELELRNEGLV KEKCAAQSQQ SIIKIVRELE ENKEAEYEKL
510 520 530 540 550
ILALRKEQNI YSTLVKTFKE SDSLNSLQTE LNNIFMLRKQ LEEDVLANRN
560 570 580 590 600
LQKVLEDQIK GIKNRQDETQ SFCGDQTSYM SICLGEQDHL SLQIDHLSLE
610 620 630 640 650
ELKKKVTDLL LLVKDLQSIN QELKKKQLGC CSTDSQGKEA LKILNHSECL
660 670 680 690 700
EITEEPVMET EDGDNDRKKR NSPFSERVSQ VCLQVSLDFP CEVDKQITPS
710 720 730 740 750
GYSESFCKDR HYRSPNKPQF EHDTNGKHFD RTGMSEHETE ENLLTSPLRE
760 770 780 790 800
NRTSVLESTR QEQMKIVNEL LDHLNTTEEE CSSEDIEEKD EKDLRQMIIQ
810 820 830 840 850
LRAELKHFKQ VNKFLKRQVE LKSTFDGKEK LYLDAVPQIN KDIELLKAEL
860 870 880 890 900
KDATTQTMTL ESNVMRVKHE GKKGASEEKP KYSRLNAERE HQQENVYKEG
910 920 930 940 950
EQHERLFYKR RANETDSTYL HKKSRLPILL KSSRSLGKVP LNSCMQKSDS
960 970 980 990 1000
KLQTNEGLKA CEVQTKQLEA QTNGELVSNE SVTENLEEEP AQESTSVRAD
1010 1020 1030 1040 1050
SLKPDHSDIQ VELQGVDLGT GDENECVMDK NQQNYQEMQN HHNICNTNNQ
1060 1070 1080 1090 1100
RSLKEINEEF YSVEHEDVDL ATTYPASKCL RSLQSSVTST DALDDCEVID
1110 1120 1130 1140 1150
DIEELKCRIK NMKSELEKYK MFVFNLQTSD QLLSSDFSNI VLSDTALPAE
1160 1170 1180 1190 1200
RHGTQVQDTA VQEIKTLPSV HQLMDYKLHT ENRNSESSEA PNTWTAQNLK
1210 1220 1230 1240 1250
ELLSANEAEL EKEQIANMHL DELYHLQNKL RETSPSKYDS LVHSQAQELS
1260 1270 1280 1290 1300
YQRQQIKEIC SACVAYHQHL TSLIKAFEEL LQASDVDYYV AEGFREQLNQ
1310 1320 1330 1340 1350
SVLLFEKLER KFLYGESIDT EGTILYELAQ RDNEKNTTMY QQLKDESPVP
1360 1370 1380 1390 1400
SALHSLSDFD LSEKSSLGSP EHRPDLEGQH STLALLPNKF PPELLMEHLQ
1410 1420 1430 1440 1450
EIRILRQRLE HSIKTNERLR KQLERQVTDK ELDQGSANIF IHGSEQHNSL
1460 1470 1480 1490 1500
TSEIHFLRKQ NQVLNAMLAK GSRDKQKENE KLRESLSKKN VIIEHLQEDY
1510 1520 1530 1540 1550
ECIKKENERL QKQIGQKEDE TRYLTCQIYS SRNELNRLQT EINIKQHQLS
1560 1570 1580 1590 1600
ENEKLLQSLR TESKVYEKLE EARRKRTDPR CDASEEFRKD QNNPLDLHEL
1610 1620 1630 1640 1650
LTEIQSLRVQ LERSIETNKS LHEKLEEQLS KEKREEAGSV SAVNINYLVK
1660 1670 1680 1690 1700
QESQHYAGMN ENLCKCPATG RNISELRKHG HCLSLAKPGT HPASKDDVDS
1710 1720 1730 1740 1750
TSHCSSTSSS STACTPRLVP GHRMWADKNG RHVLGLIEDY NALRKQISEG
1760 1770 1780 1790 1800
QQVLGEMEIS LRKVTGTKLQ ESGIKVPDQT SLHSFSANIH TVQQILEEAA
1810 1820 1830 1840 1850
RLLKLLWRVS LPLKAGPGTA HGTQDEGMKA EILRLRKKLS EQEKKLHSTV
1860 1870 1880 1890 1900
KRLHSTNQLK ENMEKVIIDQ LVLTHDVLKK ARGNLEVPAA ENQKSPTYTS

KKRIL
Length:1,905
Mass (Da):219,649
Last modified:February 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9F419F9FA8E0D3BA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AKCR02000074 Genomic DNA Translation: PKK21725.1

NCBI Reference Sequences

More...
RefSeqi
XP_013222392.1, XM_013366938.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
102083946

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
clv:102083946

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AKCR02000074 Genomic DNA Translation: PKK21725.1
RefSeqiXP_013222392.1, XM_013366938.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102083946
KEGGiclv:102083946

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55755

Phylogenomic databases

KOiK16542
OrthoDBi1046642at2759

Family and domain databases

InterProiView protein in InterPro
IPR012943 Cnn_1N
PfamiView protein in Pfam
PF07989 Cnn_1N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2I0LWA8_COLLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2I0LWA8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: January 16, 2019
This is version 6 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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