Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Acinetobacter tandoii
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 Mn2+ ion per subunit.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei77SubstrateUniRule annotation1
Metal bindingi225ManganeseUniRule annotation1
Metal bindingi245Manganese; via tele nitrogenUniRule annotation1
Binding sitei267SubstrateUniRule annotation1
Active sitei269UniRule annotation1
Metal bindingi294ManganeseUniRule annotation1
Binding sitei384GTPUniRule annotation1
Binding sitei415GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi268 – 273GTPUniRule annotation6
Nucleotide bindingi516 – 519GTPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotationSAAS annotation, KinaseImported, Lyase, Transferase
Biological processGluconeogenesisUniRule annotation
LigandGTP-bindingUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, PyruvateImported

Enzyme and pathway databases

UniPathwayiUPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Alternative name(s):
GTP-dependent phosphoenolpyruvate carboxykinaseUniRule annotation
Short name:
GTP-PEPCKUniRule annotation
Gene namesi
Name:pckGUniRule annotation
ORF Names:XA39_14975Imported
OrganismiAcinetobacter tandoiiImported
Taxonomic identifieri202954 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 237PEPCK_NInterPro annotationAdd BLAST220
Domaini241 – 602PEPCK_CInterPro annotationAdd BLAST362

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni216 – 218Substrate bindingUniRule annotation3
Regioni382 – 384Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

Family and domain databases

CDDicd00819 PEPCK_GTP, 1 hit
Gene3Di3.40.449.10, 2 hits
3.90.228.20, 2 hits
HAMAPiMF_00452 PEPCK_GTP, 1 hit
InterProiView protein in InterPro
IPR018091 PEP_carboxykin_GTP_CS
IPR013035 PEP_carboxykinase_C
IPR008209 PEP_carboxykinase_GTP
IPR035077 PEP_carboxykinase_GTP_C
IPR035078 PEP_carboxykinase_GTP_N
IPR008210 PEP_carboxykinase_N
PANTHERiPTHR11561 PTHR11561, 1 hit
PfamiView protein in Pfam
PF00821 PEPCK_C, 1 hit
PF17297 PEPCK_N, 1 hit
PIRSFiPIRSF001348 PEP_carboxykinase_GTP, 1 hit
SUPFAMiSSF68923 SSF68923, 1 hit
PROSITEiView protein in PROSITE
PS00505 PEPCK_GTP, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2H9TRM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQVNAPEFV RHPKLIAWVE EIAKLTKPAK IEWCDGSEEE YQRLIDLMIA
60 70 80 90 100
NGTMQALNQE KHPGSYLANS DPSDVARVEG RTYICSEKEE DAGATNNWEA
110 120 130 140 150
PAEMRARLNG LFDGAMQGRT MYVVPFSMGP LGSHIAHIGI ELTDSPYVAV
160 170 180 190 200
SMSKMARMGK AVYDVLGTDG EYIPCVHTVG APLAEGEKDV AWPCNPEKYI
210 220 230 240 250
VHYPETREIW SYGSGYGGNA LLGKKCLALR IASAMGREQG WLAEHMLILG
260 270 280 290 300
VTNPQGEKHY IAAAFPSACG KTNFAMLIPP AGYEGWKIET VGDDIAWIKP
310 320 330 340 350
GEDGRLYAIN PEAGFFGVAP GTNTKTNPNC MATLHKDVIY TNVAVTDNGE
360 370 380 390 400
VWWEGLSKEA PANLTNWKGQ PHTGTEKAAH PNARFTVAAG QCPSIDADWE
410 420 430 440 450
NPAGVPISAF IFGGRRADTV PLISEAFDWV DGVYKAATMG SETTAAAVGQ
460 470 480 490 500
QGIVRRDPFA MLPFAGYNMA DYFSHWLELG EEVEAKAKAA GNKLPGIYNV
510 520 530 540 550
NWFRRDAEGN FVWPGFGQNM RVLEWIIDRC EGRASAVETP IGLVPTYEQL
560 570 580 590 600
NWTGSDFTKE QFELVTSQDK DQWIKEIESH TELFNQLGDR LPAALKARQN
610
ELLAAVKAAV KQSA
Length:614
Mass (Da):67,345
Last modified:February 28, 2018 - v1
Checksum:i4086BF5048673B6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LBNL01000029 Genomic DNA Translation: PJG42029.1

Similar proteinsi

Entry informationi

Entry nameiA0A2H9TRM7_9GAMM
AccessioniPrimary (citable) accession number: A0A2H9TRM7
Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: April 25, 2018
This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health