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Protein

Allantoinase

Gene

allB

Organism
Bacillus amyloliquefaciens (Bacillus velezensis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

(S)-allantoin + H2O = allantoate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

Pathwayi: (S)-allantoin degradation

This protein is involved in step 1 of the subpathway that synthesizes allantoate from (S)-allantoin.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Allantoinase (allB), Allantoinase (allB), Allantoinase (allB), Allantoinase (allB)
This subpathway is part of the pathway (S)-allantoin degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes allantoate from (S)-allantoin, the pathway (S)-allantoin degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Zinc 1UniRule annotation1
Metal bindingi62Zinc 1UniRule annotation1
Metal bindingi147Zinc 1; via carbamate groupUniRule annotation1
Metal bindingi147Zinc 2; via carbamate groupUniRule annotation1
Metal bindingi183Zinc 2UniRule annotation1
Metal bindingi239Zinc 2UniRule annotation1
Metal bindingi312Zinc 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
Biological processPurine metabolismUniRule annotation
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00395;UER00653

Names & Taxonomyi

Protein namesi
Recommended name:
AllantoinaseUniRule annotation (EC:3.5.2.5UniRule annotation)
Alternative name(s):
Allantoin-utilizing enzymeUniRule annotation
Gene namesi
Name:allBUniRule annotation
Synonyms:pucHUniRule annotation
ORF Names:NP89_15420Imported
OrganismiBacillus amyloliquefaciens (Bacillus velezensis)Imported
Taxonomic identifieri1390 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus amyloliquefaciens group

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei147N6-carboxylysineUniRule annotation1

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two zinc ions.UniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.UniRule annotation

Family and domain databases

Gene3Di2.30.40.10, 1 hit
HAMAPiMF_01645 Hydantoinase, 1 hit
InterProiView protein in InterPro
IPR017593 Allantoinase
IPR006680 Amidohydro-rel
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51338 SSF51338, 1 hit
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR03178 allantoinase, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2H6MGP5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYDVIVKGA KAVRKGGTER ADIAVKDGKI ALIGPGIDEN AEQVVQADGM
60 70 80 90 100
YVFPGAVDCH VHFNEPGREE WEGIETGSNM LAAGGCTSYF DMPLNCIPST
110 120 130 140 150
VTAENLLAKA EIAERKSAVD FALWGGLMPG YTEHIRPMAE AGAIGFKAFL
160 170 180 190 200
SKSGTDEFQS ADERTLLKGM KEIAACGKVL ALHAESDALT RFLEAEYALQ
210 220 230 240 250
GKIDARAYAS SRPEEAECEA VQRAIEYARA TGCALHFVHI STKRAVLSIQ
260 270 280 290 300
QAKKDGLDVT VETCPHYLLF SFEDFFKKGA AAKCAPPLRS EADKEELIGV
310 320 330 340 350
LAEGLIDMVS SDHSPCHPSL KREDNMFLSW GGISGGQFTL LGMIQLAIDH
360 370 380 390 400
GIPFEHVARW TAEAPAKRFG LTNKGRLEEG FDADFAIVRP EPFTVTKETM
410 420 430 440 450
FSKHKQSLYE GRTFPYRIAA TYSKGRCVYQ DGGRKQSGAF GTFLKPSLIK

EPIL
Length:454
Mass (Da):49,463
Last modified:February 28, 2018 - v1
Checksum:iECAEB94193E8EBB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JRYS01000272 Genomic DNA Translation: KHD91203.1
RefSeqiWP_061862541.1, NZ_CP029070.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JRYS01000272 Genomic DNA Translation: KHD91203.1
RefSeqiWP_061862541.1, NZ_CP029070.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayi
UPA00395;UER00653

Family and domain databases

Gene3Di2.30.40.10, 1 hit
HAMAPiMF_01645 Hydantoinase, 1 hit
InterProiView protein in InterPro
IPR017593 Allantoinase
IPR006680 Amidohydro-rel
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51338 SSF51338, 1 hit
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR03178 allantoinase, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2H6MGP5_BACAM
AccessioniPrimary (citable) accession number: A0A2H6MGP5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: November 7, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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