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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Chromobacterium sp. ATCC 53434
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotationSAAS annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotationSAAS annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei59S-adenosyl-L-methionineUniRule annotation1
Binding sitei84S-adenosyl-L-methionineUniRule annotation1
Binding sitei111S-adenosyl-L-methionineUniRule annotation1
Binding sitei134S-adenosyl-L-methionineUniRule annotation1
Binding sitei138SubstrateUniRule annotation1
Binding sitei170SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processtRNA processingUniRule annotationSAAS annotation
LigandS-adenosyl-L-methionineUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
ORF Names:CXB49_02350Imported
OrganismiChromobacterium sp. ATCC 53434Imported
Taxonomic identifieri2059672 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeChromobacterium
Proteomesi
  • UP000234260 Componenti: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni140 – 145Interaction with RNAUniRule annotation6
Regioni205 – 208Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

KOiK03439

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2H5DRT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENPAFKRAI RSFVLRQGHL SSGQQRAMDE GMPRWGIDYR PEPVDLEQAF
60 70 80 90 100
GRAAPKILEI GFGMGGATAE IAAANPDKDY LGIEVHGPGV GNLCKLIAEK
110 120 130 140 150
ELSNLRLMRH DAVEVLDNML PDGSLDGVHI FFPDPWHKKR HNKRRLIQAP
160 170 180 190 200
LVAKLAKKLK PGGYFHAATD WEDYAIQILE VLSGDPDLEN TAADYAPRPD
210 220
YRPLTKFEAR GIKLGHGVWD LVFRRR
Length:226
Mass (Da):25,356
Last modified:February 28, 2018 - v1
Checksum:i1A9DD358ED5DAD07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP025429 Genomic DNA Translation: AUH49757.1

Genome annotation databases

KEGGichro:CXB49_02350

Similar proteinsi

Entry informationi

Entry nameiA0A2H5DRT9_9NEIS
AccessioniPrimary (citable) accession number: A0A2H5DRT9
Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: May 23, 2018
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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