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Protein

ATP-dependent (S)-NAD(P)H-hydrate dehydratase

Gene

ARMSODRAFT_954113

Organism
Armillaria solidipes
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.UniRule annotation

Catalytic activityi

ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = ADP + phosphate + NADH.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei111NAD(P)HX; via amide nitrogenUniRule annotation1
Binding sitei243NAD(P)HXUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi202 – 206ATPUniRule annotation5
Nucleotide bindingi233 – 242ATPUniRule annotation10

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseImported, LyaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, NADUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent (S)-NAD(P)H-hydrate dehydrataseUniRule annotation (EC:4.2.1.93UniRule annotation)
Alternative name(s):
ATP-dependent NAD(P)HX dehydrataseUniRule annotation
Gene namesi
ORF Names:ARMSODRAFT_954113Imported
OrganismiArmillaria solidipesImported
Taxonomic identifieri1076256 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPhysalacriaceaeArmillaria
Proteomesi
  • UP000218334 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni164 – 170NAD(P)HXUniRule annotation7

Sequence similaritiesi

Belongs to the NnrD/CARKD family.UniRule annotation

Family and domain databases

CDDicd01171 YXKO-related, 1 hit
Gene3Di3.40.1190.20, 1 hit
HAMAPiMF_01965 NADHX_dehydratase, 1 hit
InterProiView protein in InterPro
IPR000631 CARKD
IPR029056 Ribokinase-like
PfamiView protein in Pfam
PF01256 Carb_kinase, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00196 yjeF_cterm, 1 hit
PROSITEiView protein in PROSITE
PS51383 YJEF_C_3, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2H3C6I6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVPRGILEQ LKQLIPPLNG TLHKGQSGRV GVLGGALDYT GAPFFASISA
60 70 80 90 100
LRFGADLSHV ICSPTAAGAI KSYSPDLIVH PILSPDSTPD HVKSELSSLL
110 120 130 140 150
SRLHVLVIGP GLGRESYMME YAKLALNLAR SREMFIVLDA DALFMVGQDI
160 170 180 190 200
SLIKGYHRAV VTPNVVEFKR LSEQVGVDPR TPAGEQAGMV SRELGGVTVL
210 220 230 240 250
QKGAKDIISV DTTGNKASTT ENSKETVEVD IEGGMKRCGG QGDILSGAVG
260 270 280 290 300
TMLAWAKCYE DGAFGDKKLP VSRMPLLAAI GGSMVTRTAS RLAYAKQGRA
310 320
VVTEDMIPEV GPSFAEVFGE SKQGKL
Length:326
Mass (Da):34,492
Last modified:January 31, 2018 - v1
Checksum:i1EDF8B5EF7E566AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KZ293422 Genomic DNA Translation: PBK72417.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KZ293422 Genomic DNA Translation: PBK72417.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd01171 YXKO-related, 1 hit
Gene3Di3.40.1190.20, 1 hit
HAMAPiMF_01965 NADHX_dehydratase, 1 hit
InterProiView protein in InterPro
IPR000631 CARKD
IPR029056 Ribokinase-like
PfamiView protein in Pfam
PF01256 Carb_kinase, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00196 yjeF_cterm, 1 hit
PROSITEiView protein in PROSITE
PS51383 YJEF_C_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2H3C6I6_9AGAR
AccessioniPrimary (citable) accession number: A0A2H3C6I6
Entry historyiIntegrated into UniProtKB/TrEMBL: January 31, 2018
Last sequence update: January 31, 2018
Last modified: April 25, 2018
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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