UniProtKB - A0A2H1BX03 (A0A2H1BX03_FASHE)
Protein
Submitted name:
Cysteine protease
Gene
D915_009772
Organism
Fasciola hepatica (Liver fluke)
Status
Functioni
GO - Molecular functioni
- cysteine-type peptidase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, Protease, Thiol proteaseARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Cysteine proteaseImportedSubmitted name: Papain family cysteine proteaseImported |
Gene namesi | ORF Names:D915_009772Imported, D915_14227Imported |
Organismi | Fasciola hepatica (Liver fluke)Imported |
Taxonomic identifieri | 6192 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Spiralia › Lophotrochozoa › Platyhelminthes › Trematoda › Digenea › Plagiorchiida › Echinostomata › Echinostomatoidea › Fasciolidae › Fasciola |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 15 | Sequence analysisAdd BLAST | 15 | |
ChainiPRO_5024027243 | 16 – 326 | Sequence analysisAdd BLAST | 311 |
Keywords - PTMi
ZymogenARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 80 | Inhibitor_I29InterPro annotationAdd BLAST | 60 | |
Domaini | 108 – 321 | Pept_C1InterPro annotationAdd BLAST | 214 |
Sequence similaritiesi
Belongs to the peptidase C1 family.ARBA annotation
Keywords - Domaini
SignalSequence analysisFamily and domain databases
CDDi | cd02248, Peptidase_C1A, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR000169, Pept_cys_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C IPR039417, Peptidase_C1A_papain-like IPR013201, Prot_inhib_I29 |
Pfami | View protein in Pfam PF08246, Inhibitor_I29, 1 hit PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00848, Inhibitor_I29, 1 hit SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00139, THIOL_PROTEASE_CYS, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A2H1BX03-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLLILAVLF AGAFASNDVS WHEWKRMYNK EYNGADDEHR RKIWEQNVKH
60 70 80 90 100
IQEHNLRHDL GLATYTLGLN QFTDLTFEEF KAKYLIEMSP ESESLSDGIA
110 120 130 140 150
YEAEDNDVPA SIDWREYGYV TEVKNQGGCG SCWAFSTTGA IEGQYVKKFQ
160 170 180 190 200
TRVSFSEQQL VDCSTISGNH GCRGGGMRRA YEYLKKNGLE PESSYPYKAV
210 220 230 240 250
EGQCQYKSDL ALAKVTNSQL VRSGNETQLK NLIGAEGPAS VAVDVKPDFS
260 270 280 290 300
MYRSGIYQSQ TCSSRRMNHA VLAVGYGTEG GMDYWIVKNS WGPRWGEAGY
310 320
IRMARNRNNM CGIASAGSLP TVERFP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KZ434400 Genomic DNA Translation: PIS79022.1 JXXN02006160 Genomic DNA Translation: THD19552.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KZ434400 Genomic DNA Translation: PIS79022.1 JXXN02006160 Genomic DNA Translation: THD19552.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family and domain databases
CDDi | cd02248, Peptidase_C1A, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR000169, Pept_cys_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C IPR039417, Peptidase_C1A_papain-like IPR013201, Prot_inhib_I29 |
Pfami | View protein in Pfam PF08246, Inhibitor_I29, 1 hit PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00848, Inhibitor_I29, 1 hit SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00139, THIOL_PROTEASE_CYS, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A2H1BX03_FASHE | |
Accessioni | A0A2H1BX03Primary (citable) accession number: A0A2H1BX03 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 31, 2018 |
Last sequence update: | January 31, 2018 | |
Last modified: | August 12, 2020 | |
This is version 14 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |