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Entry version 12 (12 Aug 2020)
Sequence version 1 (31 Jan 2018)
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Protein

WD_REPEATS_REGION domain-containing protein

Gene

AQUCO_03700277v1

Organism
Aquilegia coerulea (Rocky mountain columbine)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD_REPEATS_REGION domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:AQUCO_03700277v1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAquilegia coerulea (Rocky mountain columbine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri218851 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaRanunculalesRanunculaceaeThalictroideaeAquilegia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000230069 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini467 – 508WD_REPEATS_REGIONInterPro annotationAdd BLAST42
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati474 – 508WDPROSITE-ProRule annotationAdd BLAST35
Repeati1370 – 1526CHCRPROSITE-ProRule annotationAdd BLAST157

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 95DisorderedSequence analysisAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 25PolarSequence analysisAdd BLAST25
Compositional biasi26 – 47PolyampholyteSequence analysisAdd BLAST22
Compositional biasi76 – 95PolarSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VPS8 family.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

RepeatARBA annotation, WD repeatPROSITE-ProRule annotationARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000547, Clathrin_H-chain/VPS_repeat
IPR025941, Vps8_central_dom
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00637, Clathrin, 1 hit
PF12816, Vps8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50236, CHCR, 1 hit
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

A0A2G5CUE5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
EILNDSDSSS SSSSSSSPSF NLKDIQHKSY SDKSPNSLSK DEEIEKSSVS
60 70 80 90 100
SPQTPVETLK PEEKKVVESI ISSFRSRKPG EFSRNSYSLG RSTTSRPLPT
110 120 130 140 150
LYGGVRVNPK PGAALAAAAA ASRSIPTPHA AAIKSRRATS EAALLNVVNS
160 170 180 190 200
ELDFVDGTEA VDTSDNVSVN VESETIKLDS RIGDSDGNAE DSPIILAEHI
210 220 230 240 250
SGREDVAEIS HENTEASSFE EACQTQEEAT KVDEIELGTN YNSNVDEGST
260 270 280 290 300
VLSSTDVVEN EKQLIDASEN ADESNLSSTC TAASDENHIP PENEVNSKVE
310 320 330 340 350
ESSVLMASEI PDAEKSHREN GLALDDTDVV EDRVVQLNSK RGGKKSGKKL
360 370 380 390 400
RSFMKPLDLA EELEKKHAYS GLHWEEGAAA QPMRLEGIRR GPPAVGYLQI
410 420 430 440 450
DANNAITRTI SHQVFRRDHG SPQVLAVHPN FIAVGMSKGF ILVVPSRYSS
460 470 480 490 500
QNADSMDAKM SVLAPQGDKS HSPVTSMCFN PQGDLLLAGY GNGNIIVWDV
510 520 530 540 550
QRSTTAKVIT GEHTAPVVHT LFLGQEFQVT RHFKAVTGDC KGLVLLHTFT
560 570 580 590 600
GVPLLRFSIK TQCLLDGQKT GIVLSASPLL IEDCGSSTAA PGNATASSSG
610 620 630 640 650
IGSMMGGVVG SSLFNERSSL VEEGVVIFVT HQTALVARLS PNLEVYARLS
660 670 680 690 700
KPDGVRDGSM PYTAWKCMTL SQGSTENLEG ETLEKASLVI AWDRKVQVGK
710 720 730 740 750
LVKSELKIYT EWTLDSAAIG VAWLDDQMLV ILTLRRQICL FSKDGNELHR
760 770 780 790 800
TSFPADGLGA DDFIVYHTYL SNLFGNPEKS YHNCLAVRGA TIYVLGPTHL
810 820 830 840 850
VASRLLPWRE RIQVLRTAGD WMGALDMAMR LYDGHAHGVI DLPRTLDAIR
860 870 880 890 900
EAIMPYLVDL ILSYVDEVFS YISVASCNQI EREAQYARVG GVAVEFCVHI
910 920 930 940 950
KRIDILFDEI FSRFVAVQHG GTFLELLEPY ILKDMLGCLP PEIMQALVEH
960 970 980 990 1000
YSSKGWLQRV EQCVLHMDIS SLDFNQVVRL CREHGLYGAL IYLFNKGLDD
1010 1020 1030 1040 1050
YKAPLEELLL ILQSSERDIA ASIGYRMLVY LKYCFSGLSF PPGHGILPHT
1060 1070 1080 1090 1100
RLPLLRKELL EFLLEDSNEM NSKLVASFKS QIGVFPNLFH LLRLDTEATL
1110 1120 1130 1140 1150
DVLKFAFPEE EANFNHGLLD ANKEDNEENN DNNTEGLNSM VQSTVNTLIH
1160 1170 1180 1190 1200
ILDIDISDEE VSSGASDMEF IEIWPSKKDT GHLLEFIAYF VARKRATIAK
1210 1220 1230 1240 1250
TVLNRILEFL TSESIFSLPS QNIDTCKRRE KQMLTLLRVV PEADWNSSYV
1260 1270 1280 1290 1300
LPLCEKAHYY QVCGYIYTTK RQYDAALDSY MKDLNEPIYA FSFINTMLLH
1310 1320 1330 1340 1350
LKDTESVNFR FAVVSKIPEL FNLSREGTFL LILDHFKEES EHILSELRSH
1360 1370 1380 1390 1400
PKSLFLYLKA TIEVHLSGTL NFSSLEKGYI PNLQTGSKPK NQLNEVELYL
1410 1420 1430 1440 1450
ERISNFPMLV RDNPFHINDE VIELYLELLC QYERNSVLKF LETFENYRVE
1460 1470 1480 1490 1500
RCLRLCQEYR VIDAAAFLLE RVGDVGSALL LTLSALNENF HKLGSAVENI
1510 1520 1530 1540 1550
VSDSSSRSYS EKQLLEVVLR IEEVNAVRDI LHSSIGLCQR NSQRLDPEES
1560 1570 1580 1590 1600
EFLWFQLLDS FCEPLRDPSD AKIVSRGNLS PLTATFDVNE EKEQSVDKWR
1610 1620 1630 1640 1650
IPKSHGGVPI LRKLFAQFIK EIVEGMIGGY VRLPTIMSKL LSDNGSQVFG
1660 1670 1680 1690 1700
DFKLIILGML GTYGFEKRIL DTAKSLIEDD TFYTMSLLKR GASHGYAPQN
1710 1720 1730 1740 1750
LLCHICGCPL TKESSISGIR VFNCGHTTHL RCEFQDHGSS NGFRDGCSVC
1760 1770 1780 1790 1800
VPKKKTRGSR SESVLIENPL VKNFVSRSQQ TQGANAVQHL HESDLVEKPY
1810 1820 1830 1840 1850
GTQQIPRFEI LSNLKKSQRS LQIETLPQLR LSPPAVYHEK IQKGTNVLGG
1860 1870 1880 1890
ESGSASVKGE NSSRQLKELK LKKSSLRFPI KSSNEMTRKL RLKTSGDLA
Length:1,899
Mass (Da):211,166
Last modified:January 31, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E7020721CA0FF6D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2G5CUF0A0A2G5CUF0_AQUCA
WD_REPEATS_REGION domain-containing...
AQUCO_03700277v1
1,956Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2G5CUE7A0A2G5CUE7_AQUCA
WD_REPEATS_REGION domain-containing...
AQUCO_03700277v1
1,902Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2G5CUL3A0A2G5CUL3_AQUCA
WD_REPEATS_REGION domain-containing...
AQUCO_03700277v1
1,903Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2G5CUE4A0A2G5CUE4_AQUCA
WD_REPEATS_REGION domain-containing...
AQUCO_03700277v1
1,325Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2G5CUE9A0A2G5CUE9_AQUCA
WD_REPEATS_REGION domain-containing...
AQUCO_03700277v1
1,439Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2G5CUF2A0A2G5CUF2_AQUCA
WD_REPEATS_REGION domain-containing...
AQUCO_03700277v1
1,033Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KZ305054 Genomic DNA Translation: PIA34902.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KZ305054 Genomic DNA Translation: PIA34902.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR000547, Clathrin_H-chain/VPS_repeat
IPR025941, Vps8_central_dom
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00637, Clathrin, 1 hit
PF12816, Vps8, 1 hit
SMARTiView protein in SMART
SM00320, WD40, 1 hit
SUPFAMiSSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50236, CHCR, 1 hit
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2G5CUE5_AQUCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2G5CUE5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 31, 2018
Last sequence update: January 31, 2018
Last modified: August 12, 2020
This is version 12 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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