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Protein

tRNA dimethylallyltransferase

Gene

miaA

Organism
Synechococcus sp. NP17
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i6A).UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Dimethylallyl diphosphate + adenine(37) in tRNA = diphosphate + N6-dimethylallyladenine(37) in tRNA.UniRule annotation

Cofactori

Mg2+UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 31ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationImported
Biological processtRNA processingUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA dimethylallyltransferaseUniRule annotation (EC:2.5.1.75UniRule annotation)
Alternative name(s):
Dimethylallyl diphosphate:tRNA dimethylallyltransferaseUniRule annotation
Short name:
DMAPP:tRNA dimethylallyltransferaseUniRule annotation
Short name:
DMATaseUniRule annotation
Isopentenyl-diphosphate:tRNA isopentenyltransferaseUniRule annotation
Short name:
IPP transferaseUniRule annotation
Short name:
IPPTUniRule annotation
Short name:
IPTaseUniRule annotation
Gene namesi
Name:miaAUniRule annotation
ORF Names:CMN98_04165Imported
OrganismiSynechococcus sp. NP17Imported
Taxonomic identifieri2024885 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus

Interactioni

Subunit structurei

Monomer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei115Interaction with substrate tRNAUniRule annotation1
Sitei138Interaction with substrate tRNAUniRule annotation1

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 31Substrate bindingUniRule annotation6
Regioni49 – 52Interaction with substrate tRNAUniRule annotation4

Sequence similaritiesi

Belongs to the IPP transferase family.UniRule annotation

Family and domain databases

HAMAPiMF_00185 IPP_trans, 1 hit
InterProiView protein in InterPro
IPR018022 IPT
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01715 IPPT, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
TIGRFAMsiTIGR00174 miaA, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2E9J030-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNHVSAASRT ATSAENPLVV ALLGPTASGK TALALEIAEH FQLDILNIDS
60 70 80 90 100
RQLYREMDIG TAKPTADQQQ RVKHHLLDLR APDQPITLQE FQQEAAEAVS
110 120 130 140 150
QVLKTRGVAF LAGGSGLYLK ALTQGLQPPA VPPQNELRLQ LRELGQPNCH
160 170 180 190 200
QLLQQADPQA AAKIAPADAV RTQRALEVLY ASGKPMSEQQ SANPPPWRVL
210 220 230 240 250
ELGLNPQELR SRIAERTHQI YQQGLMAETE QLSHRYGSDL PILKTIGYGE
260 270 280 290 300
ALGVLHGGLS EAEAIATTTR RTQQFAKRQR TWFRRQHSPY WLSGQDALSE
310
AIRLIEAGLG
Length:310
Mass (Da):34,084
Last modified:January 31, 2018 - v1
Checksum:iED9E99158BAEDC7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
PBYZ01000043 Genomic DNA Translation: MBT66320.1

Similar proteinsi

Entry informationi

Entry nameiA0A2E9J030_9SYNE
AccessioniPrimary (citable) accession number: A0A2E9J030
Entry historyiIntegrated into UniProtKB/TrEMBL: January 31, 2018
Last sequence update: January 31, 2018
Last modified: March 28, 2018
This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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