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Protein

Chemotaxis response regulator protein-glutamate methylesterase

Gene

cheB

Organism
Oceanospirillaceae bacterium
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei175UniRule annotation1
Active sitei201UniRule annotation1
Active sitei297UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processChemotaxisUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesteraseUniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheBUniRule annotation
ORF Names:CMH98_04980Imported
OrganismiOceanospirillaceae bacteriumImported
Taxonomic identifieri1899355 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesOceanospirillaceaeunclassified Oceanospirillaceae

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei574-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

PhosphoproteinUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 123Response regulatoryInterPro annotationAdd BLAST118
Domaini163 – 351CheB-type methylesteraseInterPro annotationAdd BLAST189

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Family and domain databases

CDDicd16432 CheB_Rec, 1 hit
cd00156 REC, 1 hit
Gene3Di3.40.50.180, 1 hit
HAMAPiMF_00099 CheB_methylest, 1 hit
InterProiView protein in InterPro
IPR035909 CheB_C
IPR011006 CheY-like_superfamily
IPR008248 Sig_transdc_resp-reg_CheB
IPR000673 Sig_transdc_resp-reg_Me-estase
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF01339 CheB_methylest, 1 hit
PF00072 Response_reg, 1 hit
PIRSFiPIRSF000876 RR_chemtxs_CheB, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
SSF52738 SSF52738, 1 hit
PROSITEiView protein in PROSITE
PS50122 CHEB, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2D5PCD3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADPINVLIV DDSAVVRQVL TAALNKDPDI HVMGAASDPI FAIDKMNKQW
60 70 80 90 100
PDVIVLDVEM PRMDGVTFLR KIMKEHPTPV VICSSLTDKG AETTMQAMSA
110 120 130 140 150
GAVSIITKPK VGLKQFLQDD SESIIAAVKA AGKAKLRKIL APQPVTKKLT
160 170 180 190 200
ADVVLPAAGN AMAETTDRVV ALGTSTGGTQ ALETVLSALP GVCPAIIVVQ
210 220 230 240 250
HMPEKFTAAF AERLNSICSV EVREAAHGDR LIPGRVLIAP GGRHMLLKRS
260 270 280 290 300
GAQYFVDVID GPPVSRHRPS VDVLFRSVAR AAGKNALGII MTGMGDDGAL
310 320 330 340 350
GMKEMHDAGA RTLAQDEATC VVYGMPKEAV KLGGVDKNIP LQAIPAAIIN

A
Length:351
Mass (Da):36,998
Last modified:April 25, 2018 - v1
Checksum:i4BA2128ACE355B40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NYWK01000053 Genomic DNA Translation: MAD44339.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NYWK01000053 Genomic DNA Translation: MAD44339.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd16432 CheB_Rec, 1 hit
cd00156 REC, 1 hit
Gene3Di3.40.50.180, 1 hit
HAMAPiMF_00099 CheB_methylest, 1 hit
InterProiView protein in InterPro
IPR035909 CheB_C
IPR011006 CheY-like_superfamily
IPR008248 Sig_transdc_resp-reg_CheB
IPR000673 Sig_transdc_resp-reg_Me-estase
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF01339 CheB_methylest, 1 hit
PF00072 Response_reg, 1 hit
PIRSFiPIRSF000876 RR_chemtxs_CheB, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
SSF52738 SSF52738, 1 hit
PROSITEiView protein in PROSITE
PS50122 CHEB, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2D5PCD3_9GAMM
AccessioniPrimary (citable) accession number: A0A2D5PCD3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 25, 2018
Last sequence update: April 25, 2018
Last modified: October 10, 2018
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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