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Protein

NADPH:adrenodoxin oxidoreductase, mitochondrial

Gene

fdxr

Organism
Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2 reduced adrenodoxin + NADP+ = 2 oxidized adrenodoxin + NADPH.UniRule annotation

Cofactori

FADUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei48FAD; via amide nitrogenUniRule annotation1
Binding sitei69FADUniRule annotation1
Binding sitei77FAD; via amide nitrogenUniRule annotation1
Binding sitei113FAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei240NADPUniRule annotation1
Binding sitei392FAD; via amide nitrogenUniRule annotation1
Binding sitei399NADP; via amide nitrogenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi184 – 187NADPUniRule annotation4
Nucleotide bindingi228 – 229NADPUniRule annotation2
Nucleotide bindingi399 – 401FADUniRule annotation3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandFADUniRule annotation, Flavoprotein, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH:adrenodoxin oxidoreductase, mitochondrialUniRule annotation (EC:1.18.1.6UniRule annotation)
Gene namesi
Name:fdxrImported
OrganismiIctalurus punctatus (Channel catfish) (Silurus punctatus)Imported
Taxonomic identifieri7998 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiSiluriformesIctaluridaeIctalurus
Proteomesi
  • UP000221080 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MitochondrionUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 195Pyr_redox_2InterPro annotationAdd BLAST157

Sequence similaritiesi

Belongs to the ferredoxin--NADP reductase type 1 family.UniRule annotation

Phylogenomic databases

KOiK18914

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR021163 Ferredox_Rdtase_adrenod
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PIRSFiPIRSF000362 FNR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A2D0S9H1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRHMKRSFLA LHSLLQESRC PCALTSARRL FSACASSPKV CIVGGGPAGF
60 70 80 90 100
YTAQHLLKAR SDLVVDIYER LPVPFGLVRF GVAPDHPEVK NVINTFTQTA
110 120 130 140 150
RHERCSFYGN VSVGTDVSVE ELKKAYHAVV LSYGAEGNRS MGVSGEKLAG
160 170 180 190 200
VFSARDFVGW YNGLPSKKEL HPDLSCETAV VLGQGNVALD VARILLSPWD
210 220 230 240 250
FLKKTDITQQ ALESLGASRV RRVLIVGRRG PLQIACTIKE VREMINLPET
260 270 280 290 300
KADMLPGEFE GIAEALKDLP RPRKRLTELL LKTLKVDEGQ QMVDKQWGFR
310 320 330 340 350
FLRSPVEVLP DADGKKVTGV RFSINTLEGS GEEARALPTG QTQDIECGLL
360 370 380 390 400
ISSIGYKSLL IDPSVPFDPR TSTVPNEMGR VSDTSGLYCS GWVKRGPTGV
410 420 430 440 450
IATTMNDSFE TAQILLKDLD SGTLDPSVDK AGAQEITILL KTRGVRPVSF
460 470 480
SEWEKINSGE VRRGEVLGKP REKFLDVKEM LEVAWS
Length:486
Mass (Da):53,359
Last modified:December 20, 2017 - v1
Checksum:i7EF798F48109630D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2D0S8X2A0A2D0S8X2_ICTPU
NADPH:adrenodoxin oxidoreductase, m...
fdxr
467Annotation score:

Sequence databases

RefSeqiXP_017338880.1, XM_017483391.1
UniGeneiIpu.31656

Genome annotation databases

GeneIDi108273819
KEGGiipu:108273819

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_017338880.1, XM_017483391.1
UniGeneiIpu.31656

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi108273819
KEGGiipu:108273819

Organism-specific databases

CTDi2232

Phylogenomic databases

KOiK18914

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR021163 Ferredox_Rdtase_adrenod
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PIRSFiPIRSF000362 FNR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2D0S9H1_ICTPU
AccessioniPrimary (citable) accession number: A0A2D0S9H1
Entry historyiIntegrated into UniProtKB/TrEMBL: December 20, 2017
Last sequence update: December 20, 2017
Last modified: November 7, 2018
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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